Herbicide Mechanisms of Action and Resistance

Dayan, Franck E.; Barker, Abigail L.; Bough, Raven; Ortiz, Mirella F; Takano, Hudson Kagueyama; Duke, Stephen O.

doi:10.1016/b978-0-444-64046-8.00211-1

Cited by 37 publications

(37 citation statements)

References 33 publications

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“…Higher doses of 100 g a.i. ha − 1 gave more impressive control of broad-leaved weeds like Boerhaavia diffusa, Parthenium hysterophorus, and Digeria arvensis due to the herbicidal effect over inhibition of ATP synthesis and ultimately death of weeds (Dayan et al 2019). The post-emergence application of quizalofop ethyl at 100 g a.i.…”

Section: Weed Densitymentioning

confidence: 99%

Determination of Quizalofop-p-ethyl in onion spices: Weed control efficiency, residual profile, and food safety assessment under field conditions

Hazra

Mondal

Purkait

et al. 2022

Preprint

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Monitoring for pesticide residues in onion (Allium cepa L.) is important to protect consumer health and to ensure food safety. A field experiment was conducted for two consecutive seasons with quizalofop ethyl (5% EC) @ 50 and 100 g a.i. ha-1 to evaluate weed control efficiency and to determine terminal residues. Double the recommended dose (100 g a.i. ha-1) produced higher weed control efficiency (88.53-95.13 %), lower weed density (4.15-7.73 m-2), and weed dry weight. A rapid, sensitive, and analytical method was developed using high-performance liquid chromatography with excellent linearity (r2 > 0.99). Accuracy of the method in terms of average recoveries ranged from 94.4 to 99.9 % at spiking levels of 0.04, 0.20 and 0.40 mg kg-1 with intra and inter-day precision expressed relative standard deviation RSD (%) between 0.1-2.3 and 1.7-3. The limit of quantification for quizalofop-p-ethyl was established at 0.04 mg kg-1 with signal to noise (S/N) ratio ≥10. The method was successfully applied and initial quantified residues were in the range of 2.5-4.4 mg kg-1 irrespective of seasons and doses. Finally, the presence of targeted herbicide residues in harvested samples was confirmed by liquid chromatography tandem mass spectrometry (LC-MS/MS) under optimized operating conditions. The herbicide dissipated to the lowest validated level (0.04 mg kg-1) between 10-15 days with half-life values (DT50) of 1.5-1.6 days. Dietary risk assessment assured harvested onions were safe for consumption at the recommended dose.

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Section: Weed Densitymentioning

confidence: 99%

Determination of Quizalofop-p-ethyl in onion spices: Weed control efficiency, residual profile, and food safety assessment under field conditions

Hazra

Mondal

Purkait

et al. 2022

Preprint

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“…In this case, the enzyme product and not the substrate accumulates through a complicated process. 35 This will occur when even a small fraction of the overall PPO enzymatic activity is inhibited, probably largely accounting for the very low doses of the best PPOinhibiting herbicides needed to kill weeds. Accumulation of toxic intermediates has been implicated in the MOA of the herbicides glyphosate, glufosinate, and acetolactate synthase inhibitors, as well as the highly phytotoxic inhibitors of ceramide synthase.…”

Section: Discovery Approachesmentioning

confidence: 99%

“…For example, inhibitors of PPO cause accumulation of highly toxic protoporphyrin IX. In this case, the enzyme product and not the substrate accumulates through a complicated process 35 . This will occur when even a small fraction of the overall PPO enzymatic activity is inhibited, probably largely accounting for the very low doses of the best PPO‐inhibiting herbicides needed to kill weeds.…”

Section: Discovery Approachesmentioning

confidence: 99%

The search for new herbicide mechanisms of action: Is there a ‘holy grail’?

Duke

Dayan

2021

Pest Management Science

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New herbicide modes of action (MOAs) are in great demand because of the burgeoning evolution of resistance of weeds to existing commercial herbicides. This need has been exacerbated by the almost complete lack of introduction of herbicides with new MOAs for almost 40 years. There are many highly phytotoxic compounds with MOAs not represented by commercial herbicides, but neither these compounds nor structural analogues have been developed as herbicides for a variety of reasons. Natural products provide knowledge of many MOAs that are not being utilized by commercial herbicides. Other means of identifying new herbicide targets are discussed, including pharmaceutical target sites and metabolomic and proteomic information, as well as the use of artificial intelligence and machine learning to predict herbicidal compounds with new MOAs. Information about several newly discovered herbicidal compounds with new MOAs is summarized. The currently increased efforts of both established companies and start-up companies are likely to result in herbicides with new MOAs that can be used in herbicide resistance management within the next decade.

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“…Quizalofop (2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy} propanoate) is a group 1 (acetyl-coenzyme A carboxylase or ACCase; EC 6.4.1.2) inhibitor commonly used in the management of grass weeds [12]. Grasses have a herbicide-sensitive eukaryotic form of ACCase present in both the cytosol and plastids [13]. Inhibition of ACCase enzyme in grasses causes a drastic reduction in phospholipids synthesis, disrupting membrane biosynthesis, especially in meristematic regions [14].…”

Section: Introductionmentioning

confidence: 99%

Transgenerational Effect of Drought Stress and Sub-Lethal Doses of Quizalofop-p-ethyl: Decreasing Sensitivity to Herbicide and Biochemical Adjustment in Eragrostis plana

et al. 2022

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(1) Background: Eragrostis plana Ness is a invasive C4 perennial grass in South America and very adaptable to environmental stresses. Our hypothesis is that there is a transgenerational cross-talk between environmental stresses and weed response to herbicides. This study’s objectives were to: (1) evaluate if E. plana primed by drought stress (DRY), a sub-lethal dose of quizalofop-p-ethyl (QPE), or a combination of both drought and herbicide stresses (DRY × QPE), produce a progeny with decreased sensitivity to quizalofop and (2) investigate the potential mechanisms involved in this adaptation; (2) Methods: A population of E. plana was isolatedly submitted to treatments for drought, quizalofop or drought plus quizalofop for two generations. The progenies were analyzed for sensitivity to the herbicide quizalofop and performed biochemical, chromatographic and molecular analyses.; (3) Results: In the G2 generation, the quizalofop-treated CHK population had reduced stomatal conductance and increased hydrogen peroxide and lipid peroxidation. On the other hand, there was no change in stomatal conductance, hydrogen peroxide level, and lipid peroxidation in the quizalofop-treated DRY population. In addition, this population had increased antioxidant enzyme activity and upregulated CYP72A31 and CYP81A12 expression, which was accompanied by reduced quizalofop-p-ethyl concentrations; (4) Conclusions: E. plana demonstrated a capacity for transgenerational adaptation to abiotic stresses, with the population exposed to drought stress (DRY) becoming less sensitive to quizalofop-p-ethyl treatment.

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Herbicide Mechanisms of Action and Resistance

Cited by 37 publications

References 33 publications

Determination of Quizalofop-p-ethyl in onion spices: Weed control efficiency, residual profile, and food safety assessment under field conditions

Determination of Quizalofop-p-ethyl in onion spices: Weed control efficiency, residual profile, and food safety assessment under field conditions

The search for new herbicide mechanisms of action: Is there a ‘holy grail’?

Transgenerational Effect of Drought Stress and Sub-Lethal Doses of Quizalofop-p-ethyl: Decreasing Sensitivity to Herbicide and Biochemical Adjustment in Eragrostis plana

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