Herbal remedy-associated acute renal failure secondary to Cape aloes

Luyckx, Valérie A.; Ballantine, Robert I. W.; Claeys, Magda; Cuyckens, Filip; Heuvel, H. van den; Cimanga, R.K.; Vlietinck, A. J.; Broe, Marc E. De; Katz, Ivor

doi:10.1053/ajkd.2002.31424

Cited by 86 publications

(40 citation statements)

References 12 publications

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“…It is widely held that the use of traditional remedies is common in Africa, and that many patients who visit traditional healers do not need to resort to Western Medicine, and that many patients presenting to the health units will have tried traditional remedies first (1,2). Traditional remedies are a popular choice of health care partly because they are culturally acceptable and readily available in the rural communities (1,3).…”

Section: Introductionmentioning

confidence: 99%

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Traditional remedies in children around eastern cape, South Africa

Tindimwebwa²

2004

E Af Med Jrnl

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Objective: To gauge the views of mothers and other caregivers on the use of traditional remedies in the community. Design: Descriptive study. Setting: Five health centres affliated to the UNITRA, Faculty of Health Sciences. Methods: Medical students administered a questionnaire to mothers and other caregivers. Areas covered included how commonly traditional remedies are used, experience with traditional remedies in children, reasons for use, how administered, and problems encountered. Results: There were 103 respondents, 7.8% rated use of traditional remedies non-existent, 20.4% rated it as rare and the rest said it was common. 57.3% of the respondents had used these remedies in their children, and 83.1% of them said they would use them again. Only 20.7% of respondents reported problems with these remedies, including diarrhoea, vomiting, fever and death. The preparations used were known by only 40.7% of respondents. The remedies were administered by the mother and grandmother in 82.8% of cases; and were mainly given orally, by enema or by scarification. The amount administered varied from spoonful(s) up to 2.5 l. Children of all ages were given traditional remedies, usually for diarrhoea, fevers and constipation, or as prophylactics. These remedies were used because they are effective, available and safe, or due to customary beliefs and pressure from others. Conclusion: The use of traditional remedies in children is common in communities around Umtata. There is need to study the composition and activity profiles of commonly used preparations so as to develop appropriate management protocols in case of toxicity.

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Section: Introductionmentioning

confidence: 99%

“…Whereas most traditional remedies are safe, the potential for adverse effects or intoxication exists, as does the possibility of interaction with conventional drugs (2,(5)(6)(7)(8). All these unwanted effects are even more likely to occur in children, given their special pharmacokinetics (9).…”

Section: Introductionmentioning

confidence: 99%

Traditional remedies in children around eastern cape, South Africa

Tindimwebwa²

2004

E Af Med Jrnl

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“…The cause seems to have been a possible herbdrug interaction between A. vera and sevoflurane (Lee et al, 2004). Luyckx (2002) reported a patient with acute renal failure following Aloe ingestion where no other cause could be found. A case of severe vomiting after Aloe ingestion was reported by Wang et al (2003), and Willems et al (2003) published a case of melanosis coli that developed after prolonged anthranoid self-medication.…”

Section: Adverse Effects/toxicitymentioning

confidence: 99%

Medicinal Applications and Toxicological Activities ofAloe. Products

Steenkamp

Stewart

2007

Pharmaceutical Biology

116

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Aloe (Lilliaceae) has long been used as a remedy in many cultures. Aloe products, which include the latex, gel, and whole leaf, are used, among other reasons, as laxatives, in creams for skin ailments, and as a treatment for a wide range of diseases, respectively. The heterogeneous nature of Aloe products may contribute to the diverse biological and therapeutic activities that have been observed. Variations in the composition of Aloe can result in products with different chemical and physical properties, making the comparison of products difficult. In this article, the chemistry, uses, pharmacological activity, and toxicity of Aloe gel, latex, and isolated compounds are reviewed. This article is confined to literature pertaining to Aloe vera (L.) Burm.f. (also known as A. barbadensis Miller) and Aloe ferox Miller since they are the most widely used species both commercially and for their therapeutic properties.

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“…Many herbs are not what they claim to be and often contain ingredients not listed on the label. Herbal medications consumption may be dangerous and cause problems in different organs by different mechanisms (1). Star fruit (Averrhoa carambola L.) are known to create oxalate nephrotoxicity, Thunder God Vine (Tripterygium wilfordii Hook) and some traditional African medicines such as Securida longipedunculata, Euphoria matabelensis, Callilepis laureola (Cape aloes) are potent renal tubular toxins.…”

Section: Introductionmentioning

confidence: 99%

“…Ex Meisn.) contain ephedrine and can raise the blood pressure dramatically (1)(2)(3). Tribulus terrestris that is considered as a lithotripsic and renal protective herb has been reported as a nephrotoxic (4).…”

Section: Introductionmentioning

confidence: 99%