Herbal Remedies in Central-Western Argentina, I. "Ambay": Genuine Drug and Adulterants

The methanolic extract of Verbascum thapsus was evaluated for its antiviral activity against the pseudorabies virus strain RC/79 (PrV), and also for its cytotoxic activity on Vero cells. The extract showed CC₅₀ values of 1100 µg mL⁻¹ and 1426 µg mL⁻¹ by NRU and MTT assays, respectively. The 50% inhibitory concentration of the extract for PrV plaque formation was determined at 35 µg mL⁻¹, and selectivity indices were 31.4 (NRU) and 40.7 (MTT). When cells were pre-treated with the extract prior to virus infection, the inhibition in plaque formation was 70%. PrV was highly inhibited when it was incubated with plant extract or when the extract was added during the adsorption phase (99%). However, no inhibitory effect was observed when the extract was added to the cells after the adsorption period. Thus, these results suggest that the methanolic extract of Verbascum thapsus may contain bioactive compound(s) that affect PrV mostly in the adsorption phase.

show abstract

Antiviral effect and mode of action of methanolic extract ofVerbascum thapsusL. on pseudorabies virus (strain RC/79)

Escobar

Sabini

Zanon

et al. 2012

Natural Product Research

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Herbal Remedies in Central-Western Argentina, I. "Ambay": Genuine Drug and Adulterants

Cited by 1 publication

References 0 publications

Antiviral effect and mode of action of methanolic extract ofVerbascum thapsusL. on pseudorabies virus (strain RC/79)

Antiviral effect and mode of action of methanolic extract ofVerbascum thapsusL. on pseudorabies virus (strain RC/79)

Contact Info

Product

Resources

About