Herbal/Natural Compounds Resist Hallmarks of Brain Aging: From Molecular Mechanisms to Therapeutic Strategies

Qiao, Juhui; Wang, Chenxi; Chen, Yu; Yu, Shuang; Liu, Ying; Yu, Shiting; Jiang, Lei; Jin, Chenrong; Wang, Xinran; Zhang, Peiguang; Zhao, Deyu; Wang, Jiawen; Liu, Meichen

doi:10.3390/antiox12040920

Cited by 8 publications

(2 citation statements)

References 146 publications

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“…Plants that act as antiaging carry a lot of valuable active ingredients that may help reverse the aging process. Polyphenolic compounds represent an important class of phytoconstituents and they possess potent biological activities like antioxidant, anti-inflammatory and anticancer properties which play a role in delaying, preventing or treating aging-related diseases such as cancers, nephrosclerosis, arthritis, neurodegenerative and cardiovascular diseases [ 13 ]. The main antiaging polyphenolics include quercetin, luteolin, catechins, curcumin, resveratrol and lignans.…”

Section: Introductionmentioning

confidence: 99%

Genus Curcuma: chemical and ethnopharmacological role in aging process

Elhawary,

Moussa,

Singab

2024

BMC Complement Med Ther

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Aging or senescence is part of human life development with many effects on the physical, mental, and physiological aspects which may lead to age-related deterioration in many organs. Genus Curcuma family Zingieraceae represents one of the well-studied and medically important genera with more than eighty species. The genus is reported to contain different classes of biologically active compounds that are mainly presented in diphenylheptanoids, diphenylpentanoids, diphenylalkanoids, phenylpropene derivatives, alkaloids, flavonoids, chromones, terpenoids, phenolic acids and volatile constituents. Rhizomes and roots of such species are rich with main phytoconstituents viz. curcumin, demethoxycurcumin and bis-demethoxycurcumin. A wide variety of biological activities were demonstrated for different extracts and essential oils of genus Curcuma members including antioxidant, anti-inflammatory, cytotoxic and neuroprotective. Thus, making them as an excellent safe source for nutraceutical products and as a continuous promising area of research on lead compounds that may help in the slowing down of the aging process especially the neurologic and mental deterioration that are usually experienced upon aging. In this review different species of the genus Curcuma were summarized with their phytochemical and biological activities highlighting their role as antiaging agents. The data were collected from different search engines viz. Pubmed®, Google Scholar®, Scopus® and Web of Science® limiting the search to the period between 2003 up till now.

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Section: Introductionmentioning

confidence: 99%

Genus Curcuma: chemical and ethnopharmacological role in aging process

Elhawary,

Moussa,

Singab

2024

BMC Complement Med Ther

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“…CVD is known to cause neurodegeneration and mimic AD pathology. Various natural compounds, such as sinapic acid, auraptene, 4,60-anhydrooxysporidinone [ 6 ], rosmarinic acid [ 7 ], taurine [ 8 ], and epigallocatechin [ 9 ], are known to attenuate CVD and AD by improving BBB function and maintaining BBB integrity [ 9 , 10 ]. AST is a xanthophyll carotenoid, and is found in various microorganisms ( Paracoccus carotinifaciens ), microalgae ( Haematococcus species; genus of Chlorophycecae ), yeast ( Xanthophyllomyces dendrorhous ), and marine animals, such as salmon (genus Oncorhynchus ; Salmo salar ), shrimp ( Penaeus semisulcatus ), krill ( Euphausia pacifica ), and crayfish [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin: A Marine Drug That Ameliorates Cerebrovascular-Damage-Associated Alzheimer’s Disease in a Zebrafish Model via the Inhibition of Matrix Metalloprotease-13

Paramakrishnan,

Lim,

Paramaswaran

et al. 2023

Marine Drugs

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Alzheimer’s disease (AD) is a major type of dementia disorder. Common cognitive changes occur as a result of cerebrovascular damage (CVD) via the disruption of matrix metalloproteinase-13 (MMP-13). In diabetic cases, the progress of vascular dementia is faster and the AD rate is higher. Patients with type 2 diabetes are known to have a higher risk of the factor for AD progression. Hence, this study is designed to investigate the role of astaxanthin (AST) in CVD-associated AD in zebrafish via the inhibition of MMP-13 activity. CVD was developed through the intraperitoneal and intracerebral injection of streptozotocin (STZ). The AST (10 and 20 mg/L), donepezil (1 mg/L), and MMP-13 inhibitor (i.e., CL-82198; 10 μM) were exposed for 21 consecutive days in CVD animals. The cognitive changes in zebrafish were evaluated through light and dark chamber tests, a color recognition test, and a T-maze test. The biomarkers of AD pathology were assessed via the estimation of the cerebral extravasation of Evans blue, tissue nitrite, amyloid beta-peptide aggregation, MMP-13 activity, and acetylcholinesterase activity. The results revealed that exposure to AST leads to ameliorative behavioral and biochemical changes. Hence, AST can be used for the management of AD due to its multi-targeted actions, including MMP-13 inhibition.

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