Herbal nanoparticles: A patent review

Abstract

D esign and development of herbal nanoparticles has become a frontier research in the nanoformulation arena. To update researchers, an attempt has been made to review nanoformulation-based herbal patents. This article mainly covers herbal medicines are used for the treatment of cardiovascular diseases, Parkinsonism, pulmonary diseases, proliferative diseases, Alzheimer's disease, diabetes, cancer therapy, anti-osteoporosis, and the like. It has been revealed that nanoparticles of Curcumin have been widely designed to increase its bioavailability and for treatment of cancers like breast cancer, lung cancer, pancreatic cancer, and so on. The common nanoformulated herbal medicines are Panax ginseng, Curcuma longa, Silybum marianum, Withania somnifera, Gymnema sylvestre, Salvia miltiorrhiza, and the like, having a profound future potential.

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

“…Numerous studies have confirmed the potential of curcumin in prevention and treatment of various cancer types, such as head and neck, melanoma, colon, breast, pancreatic, prostate, and ovarian cancers. The multiple molecular targeting of curcumin to selectively kill tumor cells with low intrinsic toxicity has been demonstrated in different studies (9)(10)(11). However, the properties, such as a high hydrophobicity, instability, and poor bioavailability limit its further clinical use (12).…”

Sustained release Curcumin loaded Solid Lipid Nanoparticles

“…Recently phytotherapeutics were prepared in nano size to improve pharmacokinetic and pharmacodynamics characteristics. 1 Curcumin, a phenolic compound from the plant Curcuma Longa as a traditional spice have many pharmacological activities including: antidiabetic, anti-inflammatory, anti-cancer, anti-oxidant, antibacterial, anti-HIV and anti-aging activity and hepato protective activity as well as cardiovascular benefits. 2 According to Jadhav et al (2014), curcumin as a multifunctional phytoceutical, has been patented numerously.…”

“…2 According to Jadhav et al (2014), curcumin as a multifunctional phytoceutical, has been patented numerously. 1 Studies demonstrated that curcumin acts on multiplemolecular targets to selectively kill tumour cells with low intrinsic toxicity. 1,[3][4][5] This compound is widely used in China, India and Iran as a spice and traditional herb.…”

“…1 Studies demonstrated that curcumin acts on multiplemolecular targets to selectively kill tumour cells with low intrinsic toxicity. 1,[3][4][5] This compound is widely used in China, India and Iran as a spice and traditional herb. 6 The unexpected discovery that curcumin is also a powerful iron chelator has given new insight into its multimodal mechanisms of action in gaining control of age-related iron accumulations in the brain, heart, and liver.…”

“…9 Some advantages of nanotechnology in phytoceuticals include: the probability of designing sustained release systems, enhanced physicochemical stability, enhanced permeability, improves tissue distribution and enhanced solubility and bioavailability. 1 Many novel drug delivery strategies such as liposomes, nano-or micro-emulsions, polymeric NPs and solid lipid NPs, polymer conjugates, polymeric micelles, nanocrystals, nanogels, self-assemblies and cyclodextrin inclusion complexes have been described to increase solubility, bioavailability and delivery of curcumin. 10 Solid lipid nanoparticles (SLNs) as colloidal carrier systems combine the advantages of traditional systems but avoid some of their major disadvantages.…”