Herbal Medicines for Gastrointestinal Disorders in Children and Adolescents: A Systematic Review

Anheyer, Dennis; Frawley, Jane; Koch, Anna K.; Lauche, Romy; Langhorst, Jost; Dobos, Gustav; Cramer, Holger

doi:10.1542/peds.2017-0062

Cited by 63 publications

(38 citation statements)

References 43 publications

(25 reference statements)

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“…There are such isolated mentions on the traditional indications of medicinal plants in children in various European countries, in cases of digestive diseases [26,[49][50][51][52][53][54][55][56][57][58][59], bedwetting [25], respiratory diseases [55,[60][61][62][63][64], insomnia [52,63], and growth delay [46,65]. Nevertheless, more and more scientists try to gather and systematize the available world clinical data on the safety and efficacy of various herbal medicines in children [66][67][68][69][70][71].…”

Section: Romanian Ethnomedicine and Ethnopediatry In The European Conmentioning

confidence: 99%

Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

Petran

Dragoș

Gîlcă

2020

J Ethnobiology Ethnomedicine

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Background: Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants traditionally used to treat various pediatric diseases in Romania during the 1860s-1970s. Methods: Information was mainly obtained by manual systematic search in various relevant historical works focused on the traditional use of medicinal plants in Romania (1860s-1970s), found in the Archives of Romanian Academy Library and National Romanian Library. Results: A total of 153 medicinal plants belonging to 52 families were identified as having ethnopediatric significance. The plant traditional indications, targeted body systems, parts used, and way of administration were provided. We have also proposed one index (expressed as percentage) in order to assess the ethnopediatric applicability area of species: ethnopediatric relative therapeutic versatility (ERTV), which was calculated on the basis of the number of distinct uses mentioned for a species. The species identified to have the highest ERTV scores were Dryopteris filix-mas (100%), Gratiola officinalis (85.71%), Allium sativum (71.42%), Eryngium planum (71.42%), Juglans regia (71.42%), Matricaria chamomilla (71.42%), Plantago major (71.42%). Conclusions: The present study exposed for the first time to the international scientific community important ethnopediatric information contained in several local Romanian bibliographical resources that could guide the local and international researchers towards new directions of plant valorization.

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Section: Romanian Ethnomedicine and Ethnopediatry In The European Conmentioning

confidence: 99%

Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

Petran

Dragoș

Gîlcă

2020

J Ethnobiology Ethnomedicine

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“…In some European countries, the tincture of Tormentil is traditionally used to treat diarrhea, as indicated in the HMPC monograph [30]. A review article on herbal medicinal products for gastrointestinal disorders in children evaluated the use of herbal preparations of P. erecta as a safe adjunct remedy for diarrhea [2]. Only 1 study described that the local application of codfish oil and gargling with a tincture from P. erecta in patients with the erosive ulcerative form of lichen planus of the buccal mucosa is beneficial to a quicker control of the process.…”

Section: Studies In Humansmentioning

confidence: 99%

“…One of these herbal drugs with long tradition is Tormentil derived from Potentilla erecta L., Rosaceae [1]. Although there is no approved herbal drug available in European community, the drug is traditionally used and attracts attention in complementary medicine [2].…”

Section: Introductionmentioning

confidence: 99%

Tormentillae rhizoma – Review for an Underestimated European Herbal Drug

Melzig

Böttger

2020

Planta Med

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Potentilla erecta is a medicinal plant described under its traditional name Tormentil in medieval herbal books and used until today in many European countries. Today monographs for Tormentillae rhizoma in the European pharmacopeia, as well as a monograph of the Herbal Medicinal Product Commission as a drug for traditional use, exist. The present review summarizes published investigations in phytochemistry and pharmacology, together with new findings reflecting the mechanisms of action of ellagitannins as one of the main ingredients of this herbal drug. Taken together all in vitro and in vivo investigations’ data support the traditional use for treatment of diarrhea and mucosal inflammation despite a lack of suffcient clinical studies.

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“…Their Mg levels were also not different, but the number of groups was small. Herbals are used as a traditional soothing method to relief gastrointestinal symptoms and its effectiveness is not clear for infantile colic (26). However, their relaxing mechanism is also not clear.…”

Section: Compliance With Ethical Standardsmentioning

confidence: 99%

Plasma Zinc and Magnesium Levels in Infants With Infantile Colic

Büyükgedikli¹,

Kondolot²,

Karakükçü³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: Muscle cramps, sleep disorders, and irritability due to Mg deficiency; and sleep and behavioral disorders associated with Zn deficiency and being cofactors in the melatonin synthesis have suggested that plasma Mg and Zn may be in lower levels in colicky infants. This study aimed to compare plasma Mg and Zn levels of colicky infants and the mothers with controls. Material and Methods: Fifty infants diagnosed with infantile colic and 22 controls aged 1-3 months with their mothers were included in this cross-sectional study. Colic group was divided into two subgroups; Firts infants who were given Mg-containing herbals (herbals-group, n=12) and second infants who were not given any Mg or Zn-containing supplement (study group, n=27). Plasma Mg and Zn levels were measured by Atomic Absorption Spectrophotometer on flame photometry. Results: Mg levels (mg/dl) of the infants were not different between study group (2.46±0.27) and controls (2.37±0.25) (p=0.70). However, plasma Mg levels were higher in the herbals-group (2.68±1.90) than the study group (2.46±0.27) and controls (2.37±0.25) (p=0.04, p=0,004; respectively). Zn levels (mg/dl) of the infants and Mg and Zn levels of the mothers were not different between the groups (p=0.36, p=0.61, p=0.22; respectively). In the herbals-group, four parents reported that the Mg-containing herbals were useful, but Mg levels of their infants were found similar with the infants whose parents reported that Mg-containing herbals were not useful (p=0.79). Conclusion: Plasma Mg and Zn levels of colicky infants and their mothers were not different from healthy controls in this study. Further studies are needed to determine the effect of Mg supplementation on colic severity.

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Herbal Medicines for Gastrointestinal Disorders in Children and Adolescents: A Systematic Review

Abstract: Because of the limited number of studies, results have to be interpreted carefully. To underpin evidence outlined in this review, more rigorous clinical trials are needed.

Cited by 63 publications

References 43 publications

Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s–1970s)

Tormentillae rhizoma – Review for an Underestimated European Herbal Drug

Plasma Zinc and Magnesium Levels in Infants With Infantile Colic

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