Herbal Medicines as Sources of an Evidence-Based Pharmacological Research Paradigm: improving research translation

Study on the mechanism underlying Trichosanthis peel injection‐induced improvements in myocardial fibrosis markers in patients with chronic heart failure

“…6 Regarding the development of snake gourd fruit peel into mature Trichosanthis kirilowii (Trichosanthis kirilowii Maxim) or bilateral Trichosanthis kirilowii dry skin, according to Shen Nong's herbal classic, 'the records of snake gourd fruit skin has clear heat polyester sputum, chest-wide encounters with slippery bowel, and so on; it is used for the treatment of lung heat cough, turbidity-yellow and thick phlegm, chest fullness, chest pain, lung carbuncle, mammary carbuncle, intestinal carbuncle, constipation and other diseases'. 7 A previous study analysed the fingerprint of TP and identified vanillic acid, isoquercetin, vanillic acid glucoside, rutin and colistin glucoside. 8 Existing studies have shown that it can inhibit the proliferation of myocardial fibroblasts and collagen synthesis and has an antifibrotic effect.…”

“…Traditional Chinese medicine for the treatment of CHD has been reported since the Han Dynasty, when doctor Zhang Zhongjing wrote Synopsis of Golden Chamber and described how chest impediment (i.e., CHD), heartache, shortness of breath and pulse syndrome can be treated with Trichosanthis fructus peel (TP) as the monarch medicine (i.e., primary treatment), from the phlegm to treat ‘chest impediment’ 6 . Regarding the development of snake gourd fruit peel into mature Trichosanthis kirilowii ( Trichosanthis kirilowii Maxim) or bilateral Trichosanthis kirilowii dry skin, according to Shen Nong's herbal classic, ‘the records of snake gourd fruit skin has clear heat polyester sputum, chest‐wide encounters with slippery bowel, and so on; it is used for the treatment of lung heat cough, turbidity‐yellow and thick phlegm, chest fullness, chest pain, lung carbuncle, mammary carbuncle, intestinal carbuncle, constipation and other diseases’ 7 . A previous study analysed the fingerprint of TP and identified vanillic acid, isoquercetin, vanillic acid glucoside, rutin and colistin glucoside 8 .…”