Herbal medicines and chronic kidney disease

Jha, Vivekanand

doi:10.1111/j.1440-1797.2010.01305.x

Cited by 125 publications

(70 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The kidney is the route of excretion of most of the substances present in herbs. Kidney injury has been described in association with ingestion of several botanicals (48). Therefore, kidney cells were used in the study.…”

Section: Discussionmentioning

confidence: 99%

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Asadi¹,

Nath²,

Özhan³

2015

Turk J Med Sci

View full text Add to dashboard Cite

IntroductionSince ancient times, herbs have played an important role in the treatment of different diseases in many regions of world, largely for their expectorant, aphrodisiac, diuretic, diaphoretic, antispasmodic, stomachic, and sedative properties (1). The World Health Organization reported that 70%-80% of the global population relies on herbs for primary health care. In addition, because they are natural products, it is generally believed that herbs are essentially safe and free from side effects. Consequently, the consumption of nonprescription herbs has steadily increased over the past few decades (2).Despite the therapeutic advantages of herbs, reports have indicated the potential toxicity of some herbal components. Herbs contain a variety of chemical substances that act upon the body. In addition, the quality of herbs can be affected by toxic contaminants originating from industry, agriculture, and private households, including toxins that can cause mutagenic and carcinogenic effects from long-term and widespread use (3-6). Moreover, herbal medicines are generally a mixture of a number of herbs in a single preparation and contain several active ingredients that induce various pharmacological effects (7,8). To date, there are few scientific studies on the safety and potential toxicity of herbs, despite growing concerns over the lack of both scientific evidence and quality control data regarding the safety and efficacy of herbs (9,10).Sexual dysfunction is a condition that affects 15-30 million men worldwide, and it occurs in 10%-52% of men and 25%-63% of women (11,12). Many believe that sexual dysfunction is associated with the modern lifestyle. As a result, individuals turn to natural products, such as traditional herbs, that produce aphrodisiac effects for sexual enhancement. Aphrodisiac herbs are used to treat sexual dysfunction because they alter specific neurotransmitters or sex hormones. Specifically, herbs with aphrodisiac properties can induce vasodilatation that results in a sustained erection, and can cause irritation of genital mucosa that enhances sensory experience during coitus (13).Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. Therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in Turkey. Materials and methods:Ten herbs (Anethum graveolens, Carthamus tinctorius, Citrus aurantium, Cocos nucifera, Glycyrrhiza glabra, Melissa officinalis, Nigella arvensis, Pinus pinea, Prunus mahaleb, and Zingiber officinale) were extracted with water, methanol, and chloroform. The cyto-and genotoxic potentials of the extracts were assessed using an MTT test on a rat kidney cell line and an Ames assay in Salmonella typhi...

show abstract

Section: Discussionmentioning

confidence: 99%

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Asadi¹,

Nath²,

Özhan³

2015

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…The projected market turnover in 2015 is valued to be 30 billion dollars in some estimates; however, a more detailed report by Global Industry Analysts puts the estimate at 93 billion dollars. [2][3][4][5][6][7][8] Most CAM practices are deemed to be at least harmless. However, several alarming points stand out.…”

Section: Introductionmentioning

confidence: 99%

Complementary and Alternative Medicine Use Among Patients With Chronic Kidney Disease and Kidney Transplant Recipients

Osman

Hassanein

Leil

et al. 2015

Journal of Renal Nutrition

View full text Add to dashboard Cite

“…Causes of Aristolochic Acid intoxication include long-term intake of medicinal herbs containing Aristolochic Acid [16][17][18][19] or of flour obtained from wheat contaminated with seeds of Aristolochia clematitis [16]. Aristolochic Acid is considered to be at least partially effective by inducing DNA adduct formation and mutations [1,4,8,9,13,14]. Aristolochic acid nephropathy is associated with anemia [20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%