Herbal medicine in the treatment of patients with type 2 diabetes mellitus

Pang, Guoming; Li, Fangxu; Yan, Yong; Yin, Zhang; Kong, Lili; Zhu, Peng; Wang, Kaifeng; Zhang, Fang; Liu, Bin; Lü, Cheng

doi:10.1097/cm9.0000000000000006

Cited by 69 publications

(46 citation statements)

References 75 publications

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“…With the rising importance of complementary and alternative medicine according to the recommendations of the World Health Organization (WHO) (Zhang Q. et al, 2019 ), the application and research of alternative medications for the treatment of T2DM have markedly increased in recent years (Al-Eidi et al, 2016 ; Pang et al, 2019 ). As one of the paramount types of alternative medicine, herbal medicine (HM) has thousand years of history and includes systematic medical theories based on long periods of phenotype-based and personalized clinical trials (Li and Weng, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Zheng

Gou

Zhang

et al. 2020

Front. Cell. Infect. Microbiol.

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Herbal medicines (HMs) are a major subset of complementary and alternative medicine. They have been employed for the efficient clinical management of type 2 diabetes mellitus (T2DM) for centuries. However, the related underlying mechanisms still remain to be elucidated. It has been found out that microbiota is implicated in the pathogenesis and treatment of T2DM. An interplay between gut microbiota and host occurs mainly at the gastrointestinal mucosal barrier. The host movements influence the composition and abundance of gut microbiota, whereas gut microbiota in turn modulate the metabolic and immunological activities of the host. Intestinal dysbiosis, endotoxin-induced metabolic inflammation, immune response disorder, bacterial components and metabolites, and decreased production of short-chain fatty acids are considered significant pathogenic mechanisms underlying T2DM. The interaction between gut microbiota and HMs during T2DM treatment has been investigated in human, animal, and in vitro studies. HMs regulate the composition of beneficial and harmful bacteria and decrease the inflammation caused by gut microbiota. Furthermore, the metabolism of gut microbiota modulates HM biotransformation. In this review, we have summarized such research findings, with the aim to improve our understanding of the pathogenesis and potential therapeutic mechanisms of HMs in T2DM and to provide new insights into specific targeted HM-based therapies and drug discovery.

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Section: Introductionmentioning

confidence: 99%

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Zheng

Gou

Zhang

et al. 2020

Front. Cell. Infect. Microbiol.

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“…In China, “Xiaoke” is widely treated by Chinese herbal medicines (CHMs), and adequate experience has been accumulated. [ 6 , 7 ] Several studies have shown that CHMs have good efficacy in controlling glucose, with fewer adverse events, such as gastrointestinal reactions and hypoglycemic reactions. [ 8 – 12 ] Pharmacological researches have indicated that CHMs can promote glucose uptake and improve insulin sensitivity in 3T3-L1 adipocytes, [ 13 ] inhibit β-cell apoptosis and increase β-cell number, [ 14 ] and palliate insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Shenqi Jiangtang Granules plus oral hypoglycemic agent in patients with type 2 diabetes mellitus

et al. 2021

Medicine

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Objective: Shenqi Jiangtang Granules (SQJTG) has been widely used to treat patients with type 2 diabetes mellitus (T2DM). But whether there exists sufficient evidence on the efficacy of SQJTG in the treatment of T2DM is unclear. In order to assess the effects of SQJTG for T2DM, a systematic review and meta-analysis of randomized controlled trials (RCTs) were carried out. Methods: Eight databases, namely, PubMed, The Cochrane Library, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, Chinese Scientific Journals Full-Text Database, CBM, and Wanfang database were searched up to May 2020. According to the Cochrane standards, the selection of study, the extraction of data, the assessment of study quality, and the analyses of data were carried out strictly. Then a fixed or random effects model was applied to analyze the outcomes. Results: Fifteen studies (N = 1392) in total conformed the inclusion criteria to this meta-analysis. Two subgroups were identified, based on different dose of SQJTG: oral hypoglycemic agent (OHA) vs OHA plus SQJTG (1 g); OHA vs. OHA plus SQJTG (1.5–3 g). The pooled results showed that, in comparison with OHA, OHA plus SQJTG significantly reduced fasting plasma glucose in both 1 g subgroup and 1.5–3 g subgroup; 2-hour post-meal blood glucose was also greatly reduced in the SQJTG 1 g subgroup and the SQJTG 1.5–3 g subgroup. Compared with OHA, SQJTG 1 g subgroup significantly reduced levels of glycated hemoglobin A1c, as well as the SQJTG 1.5–3 g subgroup. Homeostasis model-insulin resistance index was also reduced in both SQJTG 1 g subgroup and SQJTG 1.5–3 g subgroup; SQJTG group can also significantly reduce the total adverse events especially in reducing the incidence of hypoglycemia. Conclusions: SQJTG is an effective and safe complementary treatment for T2DM patients. This meta-analysis provides an evidence for the treatment in patients with T2DM. While owing to the high heterogeneity and the trials’ small sample size, it's crucial to perform large-scale and strict designed studies.

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“…Intriguingly, the treatment strategies of diabetes is in favor of alternative practices. Along with conventional drugs, diabetes patients are treated by diet and exercise [56]. Therefore, it has drawn much attention as the effects of AM particularly herbal medicine has been found effective in diabetes prevention, management and/or delay its complications.…”

Section: Control Of Blood Glucosementioning

confidence: 99%

Alternative Medicine: A Recent Overview

Akter¹,

Hasan²,

Rokeya³

et al. 2021

Alternative Medicine - Update

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Alternative medicine has renewed its growing public interest in recent times due to inequality of patients and healthcare professionals’ ratios with increased workload for the latter, various side effects of modern medicine, lack of complete remission from chronic diseases, high cost of new drugs, and emerging new diseases. Hence, people have become more dependent on treatment systems replying on alternative medicine or herbal medicine from traditional medicinal practitioners. Alternative medicine has grown substantially over time and encompasses several millennia of therapeutic systems. The significant areas of alternative medicine include mind–body therapies, body manipulation, and the therapies based on biological systems. Natural products based biological treatment is the most popular of them as nature has endowed us with abundance of effective pharmacologically active phytochemicals. These phytochemicals possess numerous specific clinical health benefits including antioxidant, antidiabetic, anti-inflammatory, anticancer, anti-infectious and analgesic effects. In addition, alternative medicine is easily accessible, affordable, most often noninvasive, and provides favorable benefits during terminal periods of some diseases. However, due to the lack of well-designed clinical trials, the safety and effectiveness of many alternative medicines/therapies remains elusive. This chapter will critically discuss major areas, uses, safety and regulation, current challenges & future perspectives of alternative medicine.

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Herbal medicine in the treatment of patients with type 2 diabetes mellitus

Cited by 69 publications

References 75 publications

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Interactions Between Gut Microbiota, Host, and Herbal Medicines: A Review of New Insights Into the Pathogenesis and Treatment of Type 2 Diabetes

Efficacy and safety of Shenqi Jiangtang Granules plus oral hypoglycemic agent in patients with type 2 diabetes mellitus

Alternative Medicine: A Recent Overview

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