Herbal medicine (Danggui Shaoyao San) for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials

Lee, Hye Won; Jun, Ji Hee; Kil, Ki-Jung; Ko, Byong-Seob; Lee, Choong Hwan; Lee, Myeong Soo

doi:10.1016/j.maturitas.2015.11.013

Cited by 46 publications

(41 citation statements)

References 31 publications

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“…Since then, Kampo medicine has been evolving according to Japanese character, physical constitution, environment, and circumstances. In Japan, TSS (Danggui Shaoyao San in Chinese) is primarily administered to women with gynecological disorders who experience a cold sensation in their extremities [4, 5]. According to the theory of Kampo medicine, TSS remedies blood deficiencies and improves blood circulation, as well as alleviates abnormal fluid retention in the body.…”

Section: Flammer Syndrome and Tss A Kampo Medicinementioning

confidence: 99%

Traditional medicine as a potential treatment for Flammer syndrome

et al. 2017

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Section: Flammer Syndrome and Tss A Kampo Medicinementioning

confidence: 99%

Traditional medicine as a potential treatment for Flammer syndrome

et al. 2017

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“…Danggui‐Shaoyao‐San (DSS) is a classical traditional Chinese medicine preparation for the treatment of gynecological disorders including dysmenorrhea, anemia of pregnancy, hypoovarianism, infertilitas feminis, etc. [1–2]. It is composed of six medicinal herbs, namely Angelica sinensis (Oliv.)…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra‐high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui‐Shaoyao‐San

Zhu

Guan

Zhang

et al. 2020

J of Separation Science

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A rapid, selective, and sensitive ultra-high performance liquid chromatographytandem mass spectrometry method was developed for simultaneous determination of ferulic acid, paeoniflorin, and albiflorin, the major active constituents of Danggui-Shaoyao-San, in rat plasma using geniposide as the internal standard. The plasma samples were processed by protein precipitation with acetonitrile, and then separated on a Shim-Pack XR-ODS C 18 column (75 mm × 3.0 mm, 2.2 μm) using gradient elution program with a mobile phase consisting of 0.1% aqueous formic acid and acetonitrile at a flow rate of 0.4 mL/min. The detection was achieved on a 3200 QTRAP mass spectrometer equipped with electrospray ionization source in negative ionization mode. Quantification was performed using multiple reaction monitoring mode by monitoring the fragmentation of m/z 192.9→134.0 for ferulic acid, m/z 525.0→120.9 for paeoniflorin, m/z 525.2→121.0 for albiflorin, and m/z 433.1→225.1 for the internal standard, respectively. The calibration curve was linear in the range of 5-2500 ng/mL for all the three analytes (r ≥ 0.9972) with the lower limit of quantitation of 5 ng/mL. The intraday and interday precisions were below 12.1% for all the analytes in terms of relative standard deviation, and the accuracy was within ±11.5% in terms of relative error. The extraction recovery, matrix effect and stability were satisfactory in rat plasma. The validated method was successfully applied to a pharmacokinetic study of ferulic acid, paeoniflorin, and albiflorin after oral administration of Danggui-Shaoyao-San to rats.

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“…Therefore, treatment with herbal medicine for dysmenorrhea often improves symptoms of acne associated with the menstrual cycle; however, no study on this has been conducted thus far. Gyejibokryung-hwan (GBH) and dangguijagyag-san (DJS), administered in this trial, have been long used in East Asian countries for treatment of dysmenorrhea [16, 18, 19]. The effects of GBH and DJS on dysmenorrhea have been investigated [16, 18, 19].…”

Section: Introductionmentioning

confidence: 99%

“…Gyejibokryung-hwan (GBH) and dangguijagyag-san (DJS), administered in this trial, have been long used in East Asian countries for treatment of dysmenorrhea [16, 18, 19]. The effects of GBH and DJS on dysmenorrhea have been investigated [16, 18, 19]. The prescription of the two herbal medicines is usually determined by a physical state diagnosis according to TKM patterns [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial

Lee

Nam

Kim

et al. 2017

BMC Complement Altern Med

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BackgroundThe incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Therefore- we designed this study to assess the effects of gyejibokryung-hwan (GBH) and dangguijagyag-san (DJS), which are widely used in dysmenorrhea treatment, on acne associated with menstruation cycle.MethodsThis is a protocol for a randomized, double-blind, parallel-group, placebo-controlled and multicenter trial. One hundred and sixteen participants with dysmenorrhea accompanied by acne vulgaris will be recruited at three centers and randomized into two groups, the herbal treatment group and placebo group. The participants will receive GBH or DJS based on pattern identification or placebo granules thrice daily for 8 weeks, with an 8-week follow up. The primary outcome will be the mean percentage change in the count of inflammatory acne lesions. The secondary outcomes would be based on dysmenorrhea numeric rating scale, verbal multidimensional scoring system for dysmenorrhea, acne numeric rating scale, investigator’s static global assessment scale of facial acne vulgaris, and safety testing. Adverse events will also be reported.DiscussionThe effects of GBH or DJS used in dysmenorrhea treatment on acne associated with the menstrual cycle will be evaluated. The findings of this trial will provide evidence regarding the effect of herbal medicine in improving acne vulgaris associated with menstruation in women.Trial registrationKorean Clinical Trial Registry (http://cris.nih.go.kr; registration number: KCT0002259). Date of registration: March 10, 2017

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Herbal medicine (Danggui Shaoyao San) for treating primary dysmenorrhea: A systematic review and meta-analysis of randomized controlled trials

Cited by 46 publications

References 31 publications

Traditional medicine as a potential treatment for Flammer syndrome

Traditional medicine as a potential treatment for Flammer syndrome

Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra‐high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui‐Shaoyao‐San

Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial

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