Herbal medicine (Bojungikki-tang) for allergic rhinitis

Lee, Ju Ah; Jang, Soobin; Jun, Ji Hee; Lee, Myeong Soo; Lee, Eun-Hee; Kim, Nam-Kwen; Lee, Dong Hyo

doi:10.1097/md.0000000000009551

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…BJIGT, which is composed of eight herbal medicines (Table 3) including Astragali Radix, Ginseng Radix, Atractylodis Rhizoma Alba, Glycyrrhizae Radix et Rhizoma, Angelicae Gigantis Radix, Citri Unshius Pericarpium, Cimicifugae Rhizoma, and Bupleuri Radix, has been identified as an effective agent for the treatment of acute gastric injury [34], allergic rhinitis [35], and fatigue associated with chronic diseases [36]. The main classes of ingredients in Bojungikgi-tang are as follows: Flavonoids (e.g., formononetin and calycosin) and triterpene saponins (astragaloside I–IV) from Astragali Radix [37]; triterpene saponins (e.g., ginsenoside Rg1 and Rb2) from Ginseng Radix [38]; sesquiterpenes (e.g., atractylon and atractylenolide Ⅰ–Ⅲ) from Atractylodis Rhizoma Alba [39]; flavonoids (e.g., liquiritin and liquiritigenin) and triterpene saponins (e.g., glycyrrhizin) from Glycyrrhizae Radix et Rhizoma [40]; coumarins (e.g., decursin, decursinol angelate, and nodakenin) from Angelicae Gigantis Radix [41]; flavonoids (e.g., hesperidin) from Citri Unshius Pericarpium [42]; phenols (e.g., ferulic acid and isoferulic acid) from Cimicifugae Rhizoma [43]; and triterpene saponins (e.g., saikosaponin A, C, and D) from Bupleuri Radix [44].…”

Section: Discussionmentioning

confidence: 99%

Bojungikgi-Tang, a Traditional Herbal Formula, Exerts Neuroprotective Effects and Ameliorates Memory Impairments in Alzheimer’s Disease-Like Experimental Models

et al. 2018

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Bojungikgi-tang (BJIGT; Bu Zhong Yi Qi Tang in China, Hochuekkito in Japan) is a traditional Oriental herbal formula comprised of eight medicinal herbs that has long been used for the treatment of digestive disorders. A recent clinical study from South Korea reported that BJIGT-gamibang administration may be effective in treating dementia. We aimed to establish scientific evidence for the anti-dementia effects of BJIGT using in vitro and in vivo experimental models. We measured amyloid- β (Aβ) aggregation, β-secretase (BACE), and antioxidant activity in a cell free system. Neuroprotective effects were assessed using CCK-8. Imprinting control region (ICR) mice were divided into the following six groups: Normal control, Aβ-injected, Aβ-injection + oral BJIGT gavage (200, 400, or 800 mg/kg/day), and Aβ-injection + oral morin administration (10 mg/kg/day). Subsequently, behavioral evaluations were conducted and brain samples were collected from all the animals and assessed. BJIGT enhanced inhibition of Aβ aggregation and BACE activity in vivo, as well as antioxidant activity in in vitro, cell-free systems. BJIGT also exerted neuroprotective effects in a hydroperoxide (H2O2)-induced damaged HT22 hippocampal cell line model. In addition, BJIGT administration significantly ameliorated cognitive impairments in Aβ-injected mice, as assessed by the passive avoidance and Y-maze tests. Furthermore, BJIGT treatment suppressed Aβ aggregation and expression, as well as expression of Aβ, NeuN, and brain-derived neurotrophic factor (BDNF) in the hippocampi of Aβ-injected mice. Overall, our results demonstrate that, with further testing in clinical populations, BJIGT may have great utility for the treatment of dementia and especially Alzheimer’s disease.

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Section: Discussionmentioning

confidence: 99%

Bojungikgi-Tang, a Traditional Herbal Formula, Exerts Neuroprotective Effects and Ameliorates Memory Impairments in Alzheimer’s Disease-Like Experimental Models

et al. 2018

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“…There is an increasing demand for natural antioxidants for curing and prevention of diseases indicating that compounds in natural formulations are more active than their isolated form [31]. During the recent years many changes have occurred in the management of allergic rhinitis by using medicines in various traditional medicinal systems [32, 33]. A number of scientific investigations have proven the association between antioxidants and allergic diseases and antioxidant intake seems to have a protective effect on allergic diseases like rhinitis [34–36].…”

Section: Resultsmentioning

confidence: 99%

Comparative Phytochemical Analysis and Antioxidant Activities of Tamalakyadi Decoction with Its Modified Dosage Forms

Dahanayake

Perera

Galappatty

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background and Objective. Tamalakyadi decoction (TD) is a classical formulation mentioned in authentic traditional medicine text Sarasankshepaya under nasal diseases and used as a remedy for allergic rhinitis. It consists of 12 plant ingredients. Decoction preparations are widely used in Sri Lankan traditional system and considered effective and safe for treating many disorders. However, decoctions have to be used only in fresh state due to shorter shelf life and loss of stability. This decoction preparation method leads to decreasing the patient compliance and is also time consuming. Hence, the objective of the present study was to convert TD to consumer friendly novel dosage form, namely, freeze dried, spray dried, and traditional ganasara forms. Methodology. Therefore, we compared the phytochemical constituents and antioxidant activities of TD with its modified dosage forms. The chemical comparison of four dosage forms comprises phytochemical screening, TLC and HPTLC fingerprint profiles and the antioxidant activities by DPPH free radical scavenging activity, Ferric reducing antioxidant power (FRAP), total polyphenol content (TPC), and total flavonoid content (TFC). Results. Phytochemical screening revealed the presence of alkaloids, saponins, tannins, steroids, flavonoids, phenols, and terpenoids in all dosage forms. However, the saponins, alkaloids, flavonoids, terpenoids, and steroids were more prominent in TD and freeze dried preparation than the other two preparations. HPTLC fingerprint pattern of freeze dried dosage was more similar with HPTLC fingerprint pattern of TD in terms of number of peaks and their intensity compared to that of spray dried and ganasara dosage forms. Antioxidant activities such as DPPH, FRAP, TPC, and TFC were higher in decoction and freeze dried preparation than in spray dried and ganasara preparation. Conclusion. Freeze dried TD is the most suitable ready to use preparation having similar chemical properties and antioxidant activities to TD.

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“…Furthermore, Chinese Herbal Medicine (CHM) was found effective to reduce symptoms and enhance quality of life of patients with AR (Chan & Chien, 2014;Hon, Fung, Leung, Lam, & Lee, 2015;Lee et al, 2018;Zhang, Lan, Zhang, & Zhang, 2018). In the future, CHM may serve as an important supplementary means to AR treatment, although its specific biological mechanism remains to be further revealed.…”

Section: Arachidonic Acid Metabolismmentioning

confidence: 99%

Serum metabolomics study of patients with allergic rhinitis

Ma¹,

Wang

et al. 2020

Biomedical Chromatography

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Allergic rhinitis (AR) negatively affects the healthy lives of many individuals. Most previous studies on AR focused on the expression of cytokines, with only a few analyzing cytokine expression from a metabolomics viewpoint. Therefore, it is worthwhile to study AR at the metabolic level. Consequently, we aimed to identify differential serum biomarkers by metabolomics. In this study, the orthogonal partial least squares discriminant analysis (OPLS‐DA) model was applied to characterize the differences in serum samples collected from patients with AR and healthy volunteers. Ten metabolites (except hexadecanoic acid) were found to be altered significantly (p < .05) in the former group, according to results of principal component analysis and OPLS‐DA, indicating that these metabolites could be potential biomarkers. MetaboAnalyst 4.0 and pathway enrichment analysis showed that these changes in metabolites mainly involved three pathways, namely, porphyrin and chlorophyll metabolism, arachidonic acid metabolism, and purine metabolism. Our findings may contribute to a better understanding of the potential pathogenesis mechanisms and provide a metabolic evidence for in‐depth studies of AR.

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Herbal medicine (Bojungikki-tang) for allergic rhinitis

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 19 publications

Bojungikgi-Tang, a Traditional Herbal Formula, Exerts Neuroprotective Effects and Ameliorates Memory Impairments in Alzheimer’s Disease-Like Experimental Models

Bojungikgi-Tang, a Traditional Herbal Formula, Exerts Neuroprotective Effects and Ameliorates Memory Impairments in Alzheimer’s Disease-Like Experimental Models

Comparative Phytochemical Analysis and Antioxidant Activities of Tamalakyadi Decoction with Its Modified Dosage Forms

Serum metabolomics study of patients with allergic rhinitis

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