Herbal medicine and treatment of diabetes in Africa: an example from Guinea

Baldé, NM; Youla, A; Baldé,; Kake, Amadou; Diallo, MM; Balde, MA; Maugendre, D

doi:10.1016/s1262-3636(07)70265-3

Cited by 77 publications

(59 citation statements)

References 19 publications

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“…The widespread use of herbal remedies and healthcare preparations, such as those described in ancient texts like the Vedas and Bible have been traced to the occurrence of natural products with medicinal properties (Ajay Kumar et al, 2010). Currently, medicinal plants continue to play an important role in the management of diabetes mellitus, especially in development countries, where many people don't have access to conventional antidiabetic therapies (Blade et al, 2006). The currently available drug regimens for management of diabetes mellitus have certain drawbacks and therefore there is a need to find safer and more effective antidiabetic drugs (Duraipanadiyan et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Al–Fartosy

2015

American Journal of Biochemistry and Biotechnology

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Lycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found to be non-toxic at 1000 mg kg −1 , as no deaths or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice. In GLBF (500 mg kg −1 ), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In the chronic study, repeated administration (once a day for 21 days) of the glibenclamide and GLBF caused a significant reduction in the serum glucose level as compared to the diabetic control group. GLBF (500 mg kg −1 ) treatment prevented a decrease in the body weight of the diabetic rats. Moreover, the results revealed that GLBF (500 mg kg −1 ) treatment for 21 days significantly (p<0.01) reduced the levels of lipid profile, lipid peroxidation, improving kidney and liver functions, enhanced insulin level and increased the levels of enzymatic and non-enzymatic antioxidants. The findings in this study suggest that polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) possess good pharmacological activities, which might be helpful in controls the blood glucose level, improves body weight, lipid metabolism and prevents diabetic complications associated with lipid peroxidation and also maintains the antioxidant enzymatic and nonenzymatic in experimental diabetic rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Al–Fartosy

2015

American Journal of Biochemistry and Biotechnology

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“…In Africa, the traditional medicinal system is ritually followed in Guinea [122] and nearly 45000 species of medicinal plants are used in the treatment of various diseases [123]. Herbal formulations available in the market, their dosage and health claims…”

Section: Traditional Medicinal System Prevalent In Africamentioning

confidence: 99%

Traditional Medicinal Systems for Treatment of Diabetes Mellitus: A Review

Kumar

Tomer

2018

Int J Pharm Pharm Sci

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Diabetes mellitus (DM) is a chronic disease which has clinched the world. More than 300 million people of the world are suffering from this disease and the number is still increasing at a rapid rate as modern medical science has no permanent solution for the disease. Current scenario of the nutraceuticals has increased patient's faith on the traditional medicinal system and world nutraceutical industry is estimated to reach $285.0 billion by 2021. The increasing trend of nutraceuticals in diabetes treatment makes it important to collect the traditional knowledge of medicines under one heading as it can help researchers to formulate new functional foods and nutraceuticals which can either lower down the risk or cure DM. In addition, the discussion of market available food products, their active components and possible health benefits can help the patients to understand the herbal medicines in a better way.

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“…Botanical samples were identified and/or confirmed in national herbarium of Cameroon. Voucher specimens were deposited in the Institute of Medical Research and Studies of Medicinal Plants [3].…”

Section: Introductionmentioning

confidence: 99%