Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Tiwari, Ruchi; Latheef, Shyma K.; Ahmed, Ishtiaq; Iqbal, Hafiz M.N.; Bule, Mohammed Hussen; Dhama, Kuldeep; Samad, Hari Abdul; Karthik, Kumaragurubaran; Alagawany, Mahmoud; El‐Hack, Mohamed E. Abd; Yatoo, Mohd Iqbal; Farag, Mayada R.

doi:10.2174/1389200219666180129125436

Cited by 112 publications

(78 citation statements)

References 380 publications

(432 reference statements)

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“…The sources of these medicinal remedies are part of long traditions in different regions of the world, such as traditional Chinese medicine, which have been developed through empirical experience. Traditional medicine employs a holistic approach to the prevention of disease and traditional herbal medicines are a source of components with therapeutic value (Tiwari et al, 2018). Many studies have been conducted also on preparations of C. officinalis and have revealed constituents that influence the innate immune system through the stimulation of macrophages and lymphocytes, and modulation of the cytokine profile, which leads to a reduction of the incidence of infections or allergic diseases.…”

Section: Unique Biological and Pharmacological Activities Of C Mas Amentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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Section: Unique Biological and Pharmacological Activities Of C Mas Amentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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“…Plants have been used medicinally for several years (Abd Rani et al, 2018;Parente et al, 2012;Ricardo, Dias, Mugge, Leite, & Brandao, 2018;Tiwari et al, 2018). C. officinalis, a species used in Europe for the treatment of wounds since the 13th century, and a large number of cosmetics and personal care were developed through their compounds (Hartmann et al, 2017;Parente et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Evolution of a diabetic foot wound with the use of calendula: A single‐case experimental design

Fiuza

Maciel

Pereira

et al. 2019

Phytotherapy Research

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“…There are certain limitations of anthelmintics including development of resistance and presence of drug residues which cause health problems in humans (Wolstenholme et al, 2004). To overcome these hazards, alternative sources for example, ethnoveterinary medicine or plants having anthelmintic properties are recommended (Gathuma et al, 2004;Mahima et al, 2012;Tiwari et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of Trace Element Supplementation on the Gastrointestinal Parasites of Grazing Sheep

2020

THE JAPS

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Alternative gastrointestinal (GI) parasite control strategies including phytomineral/ trace-element supplementation have gained currency in preview of anthelmintic resistance in the grazing sheep. This paper reports an association of the selected plants/ forages having optimum levels of Zinc (Zn), Copper (Cu), Manganese (Mn) and Cobalt (Co) on the GI parasitic burden in sheep and hence on the productive performance of the grazing sheep of Multan district, Punjab, Pakistan. To this end, levels of trace elements were determined in the plants/ forages preferred by the grazing sheep, and in the sera of randomly selected grazing sheep (n =384). Serum trace element profile was correlated with the GI parasitic burden to determine the possible impact of trace-elements on GI parasitic load. After pre-treatment, wet digestion of sera and plants, concentration of the selected minerals (Cu, Co, Zn and Mn) were measured using spectrophotometry. Faecal samples (n=384) were subjected to the quantitative faecal examination using McMaster technique. Overall 42.44% prevalence of GI parasites was found in the study population. Of the eight screened forages, Cynodon dactylon, Launaea nudicaulis and Digitaria sanguinalis showed top three levels of Mn in decreasing order. Comparative mineral profile of sera was significantly different among the four tehsils (administrative units) of Multan district, Punjab, Pakistan. Mn showed significant correlation with the egg per gram (EPG) of faeces in sheep of tehsil Shujabad, whereas, Cu, Zn and Co showed insignificant results in all tehsils of Multan district. Further research is needed to explain the possible mechanism involved in the role of Mn in the indirect resilience of animals against the GI parasites. These forages might be preferred as holistic approach and possible use as a preventive management of GI parasitism in grazing sheep of the country.

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Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Abstract: In summary, this review summarizes the current status and future prospects regarding the immunomodulatory potential of various herbs and plants and their promising utility for designing and developing effective drugs and medicines in safeguarding the health of humans, animals, and poultry.

Cited by 112 publications

References 380 publications

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Evolution of a diabetic foot wound with the use of calendula: A single‐case experimental design

Effect of Trace Element Supplementation on the Gastrointestinal Parasites of Grazing Sheep

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