Herbal glycosides in healthcare

Soto-Blanco, Benito

doi:10.1016/b978-0-323-85852-6.00021-4

Cited by 16 publications

(10 citation statements)

References 308 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research indicates that low expression or loss of PTEN was previously observed in the fibrotic liver tissues of rats treated with activated hematopoietic stem cells and CCl4 [27]. Targeting PTEN alleviated liver fibrosis, while saponin A promoted the expression of PTEN by binding with DNMT1, thereby reducing liver fibrosis [28]. Bueno et al [29] also found that after knocking out the PTEN gene in alveolar epithelial cells, the degree of pulmonary fibrosis was aggravated Additionally, PTEN is associated with autophagy: Research indicates that SLC9A3R1 increases the expression of PTEN via interaction with PTEN, PTEN increases autophagy, whereas the loss of PTEN results in the inhibition of autophagy [30];Inhibition of autophagy increases PTEN, whereas induction of autophagy decreases PTEN [31] .In this study, PTEN gene and protein levels were downregulated in each iAs 3+ dose group.…”

Section: Discussionmentioning

confidence: 91%

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

Huang¹,

Ding²,

Yuan³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Exposure to inorganic arsenic (iAs) remains a global public health problem. The liver is the main target organ of arsenic, leading to arsenic-induced liver fibrosis. Autophagy is involved. Phosphatase and tensin homology deleted on chromosome ten (PTEN) may participate in arsenic-induced liver fibrosis by regulating autophagy, but the exact mechanisms remain unclear. We established a mouse model of arsenic poisoning through the drinking water, and a fibrosis model using the huma stellate cell (HSC) line LX-2, which was exposed to NaAsO2 for 24h. HE and Masson staining was adopted to observe the degree of liver fibrosis. The cells were transfected using PTEN overexpression plasmid. Western blot and qRT-PCR were used to determine the levels of protein/mRNA expression. The in vivo results were confirmed in HSCs exposed to NaAsO2, with changes suggesting fibrosis as seen in mice. NaAsO2 upregulated the expression of the autophagic markers microtubule-associated protein light chain A/B (LC3), recombinant human autophagy effector protein (Beclin-1), hairy and enhancer of split homolog-1 (HES1), but downregulated PTEN. α-smooth muscle actin (α-SMA) expression was significantly upregulated in all NaAsO2 groups. PTEN overexpression altered NaAsO2-induced autophagy which LC3, Beclin-1 were downregulated. Notch1, HES1, α-SMA, and collagenⅠexpression were all downregulated in the NaAsO2 groups. In conclusion, PTEN overexpression might decrease autophagy and inhibit fibrosis progression caused by this toxin. The NOTCH1/HES1 pathway is likely to be involved in this process. Most previous studies did not investigate PTEN and arsenic-induced liver fibrosis specifically. The present study highlights the importance of targeting PTEN for the management of arsenic exposure.

show abstract

Section: Discussionmentioning

confidence: 91%

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

Huang¹,

Ding²,

Yuan³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…2). 14 Among the many glycosides naturally produced in plants, relatively few have been studied. The structures and functions of many complex natural product glycosides remain to be discovered, due to the challenges associated with compound isolation and structural elucidation.…”

Section: Natural Product Glycosides Are Important In Drug Discovery A...mentioning

confidence: 99%

Plant glycosyltransferases for expanding bioactive glycoside diversity

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Alternatively, therapeutic applications could be employed as another classification basis, such as cardiac glycosides, which are well-known for their positive effects on cardiac arrhythmia. 65,67,68 The unique structure of glycosides has resulted in their wide therapeutic applications, including antioxidant, immunomodulatory effects, anticancer, and anticoagulant. [69][70][71] Studies have shown that glycosides, such as sativoside, derived from Stevia rebaudiana leaves downregulate pro-inflammatory cytokines production.…”

Section: -4 Glycosidesmentioning

confidence: 99%

Immunomodulating Phytochemicals: An Insight into their Potential Use in Cytokine Storm Situations.

Alarabei,

Abd Aziz,

AB Razak

et al. 2023

Adv Pharm Bull

View full text Add to dashboard Cite

Phytochemicals are compounds found in plants that possess a variety of bioactive properties, including antioxidant and immunomodulatory properties. Recent studies have highlighted the potential of phytochemicals in targeting specific signalling pathways involved in cytokine storm, a life-threatening clinical condition resulting from excessive immune cell activation and oversupply of proinflammatory cytokines. Several studies have documented the immunomodulatory effects of phytochemicals on immune function, including their ability to regulate essential cellular and molecular interactions of immune system cells. This makes them a promising alternative for cytokine storm management, especially when combined with existing chemotherapies. Furthermore, phytochemicals have been found to target multiple signalling pathways, including the TNF-α/NF-κB, IL-1/NF-κB, IFN-γ/JAK/STAT, and IL-6/JAK-STAT. These pathways play critical roles in the development and progression of cytokine storm, and targeting them with phytochemicals represents a promising strategy for controlling cytokine release and the subsequent inflammation. Studies have also investigated certain families of plant-related constituents and their potential immunomodulatory actions. In vivo and in vitro studies have reported the immunomodulatory effects of phytochemicals, which provide viable alternatives in the management of cytokine storm syndrome. The collective data from previous studies suggest that phytochemicals represent a potentially functional source of cytokine storm treatment and promote further exploration of these compounds as immunomodulatory agents for suppressing specific signalling cascade responses. Overall, the previous research findings support the use of phytochemicals as a complementary approach in managing cytokine storm and improving patient outcomes.

show abstract

Herbal glycosides in healthcare

Cited by 16 publications

References 308 publications

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

Plant glycosyltransferases for expanding bioactive glycoside diversity

Immunomodulating Phytochemicals: An Insight into their Potential Use in Cytokine Storm Situations.

Contact Info

Product

Resources

About