Herbal Extracts as Potential Antioxidant, Anti‐Aging, Anti‐Inflammatory, and Whitening Cosmeceutical Ingredients

Abstract

The aim of this research was to investigate and compare the antioxidant, anti-tyrosinase, anti-aging, and antiinflammatory activities of 16 herbal extracts for topical application in cosmetic/cosmeceutical products. Herbal plant materials were extracted by infusion in boiled water for 15 min. The total phenolic content and total flavonoid content of each extract were investigated by the Folin-Ciocalteu and aluminum chloride methods, respectively. Antioxidant activities were investigated using 2,2'-diphenyl-1-picrylhydrazyl and a ferric reducing antioxidant power assay. Anti-tyrosinase and anti-aging activities were investigated using an in vitro enzymaticspectrophotometric method. Anti-inflammatory activities were investigated using an enzyme-linked immunosorbent assay. The findings show that the Stevia rebaudiana extract has the most significant levels of both phenols and flavonoids (p < 0.05). The S. rebaudiana, Rosa damascene, and Phyllanthus emblica extracts possessed the most significant antioxidant activities (p < 0.05) and a promising whitening effect with moderate antityrosinase activities. Furthermore, the Echinacea purpurea extract possessed the most significant anti-collagenase (78.5 � 0.0 %), anti-elastase (69.0 � 1.4 %), and anti-hyaluronidase activity (64.2 � 0.3 %). The Morus alba extract possessed the most significant anti-inflammatory activity since it could inhibit the secretion of interleukin-6 and tumor necrosis factor-α (p < 0.05). Therefore, these herbal extracts have promising skin benefits and have potential for use as active ingredients in cosmetic/cosmeceutical products.

Multiple Bioactivities of Manihot esculenta Leaves: UV Filter, Anti-Oxidation, Anti-Melanogenesis, Collagen Synthesis Enhancement, and Anti-Adipogenesis

“…Sunscreen application containing UV filters is a practical prevention approach to skin photoaging [ 11 , 15 , 16 , 17 ]. However, UV-filter skin-penetration-induced allergies and dermatitis are concerning issues [ 18 ].…”

“…In addition to skin-aging problems, oxidative-stress-related obesity and cellulite development have become further intricate aesthetic concerns among consumers. Therefore, prevention and treatment through anti-adipogenic effects that inhibit the preadipocyte differentiation and lipid accumulation of anti-obesity agents have been proposed [ 8 , 9 , 10 , 11 ].…”

“…In addition, holistic outcomes contribute to rational and complex phytochemical compositions in natural extracts that possess multiple bioactivities, and have drawn significant attention from consumers and manufacturers. For example, phenolics and flavonoids are acknowledged for their cosmeceutical activities and are used in numerous anti-aging products; these cover UV filtering, anti-oxidation, anti-inflammation, anti-melanogenesis, collagen degradation inhibition, and the stimulation of collagen synthesis [ 11 , 12 , 13 ], which are safe and sustainable for long-term use. Therefore, this study aimed to investigate the cosmeceutical potential of cassava leaves, focusing on their phytochemical composition and cosmeceutical effects to encompass further research and development, which ultimately lead to sustainable and rational utility.…”

A Comparative DFT Study on the Antioxidant Activity of Some Novel 3‐Hydroxypyridine‐4‐One Derivatives

“…In order to prevent or reduce oxidative stress, exogenous antioxidants that scavenge free radicals are used. Typical examples of such compounds are α‐tocopherol, ascorbic acid, carotenoids and natural polyphenols [15–19] …”

Determination of the Content of Phenolic Compounds and the Changes of Polyphenol Oxidase and Each Index during Browning of Phyllanthus emblica at Different Storage Temperatures

“…is experiment is based on previous research and consulting relevant literature [3,[10][11][12][13][14], and we found that GA, ascorbic acid, EA, rutin, quercetin, and catechol are the main compounds in these fractions. In order to find more quality control compounds, we choose the 1-galloylglucose, GA, TGG, EA, and rutin as detection indicators.…”