Herbal Drugs in Traditional Japanese Medicine

Hatano, Tsutomu

doi:10.5772/53126

Cited by 3 publications

(3 citation statements)

References 28 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports showed that ß-sitosterol had an apoptosis inducing activity and reduced the growth of cancer cells [21,22]. Quercetin was exhibited the G2 arrest and apoptosis inducing effect on BGC-823 gastric cancer cells [23]. It was also reported that increasing the expression of quercetin was reduced the expression of survivin and activated caspase3 in breast cancer cell line [14].…”

Section: Discussionmentioning

confidence: 96%

“…In this study, we attempted to isolate the antitumor phytoconstituents contained in SSM. The major polyphenolic constituents of SSM are reportedly proanthocyanidins, which are abundant on the back of the leaves, producing the red pigment [23]. However, when the leaves were boiled, the backside color was turned from red to green, but the antitumor activity remained intact ( Figures 4a, 4b), suggesting that the red color substance(s) are not antitumor component of SSM against the MKN45 gastric cancer cells, as well as exclusion of proteins.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-cancer Effect of Saxifraga stolonifera Meerb

Nagata¹,

N²

2016

Clin Exp Pharmacol

View full text Add to dashboard Cite

Background: Saxifraga stolonifera Meerb (SSM) or Yukinoshita in Japanese has been used as a medicinal plant in China and Japan since ancient times. We conducted this research to evaluate the antitumor effects of SSM and explored antitumor factors. Methods: An extract of SSM was added to cultured cells of various cancers to assess its anti-proliferative effect. Next, a peritoneal dissemination model was created by intraperitoneally injecting gastric cancer cells (NKN45) to each nude mouse. Then, the extract of SSM was orally administered to the mice to evaluate its antineoplastic effect in vivo. In addition, in order to identify antitumor phytoconstituents, isolation and fraction of active CHCl 3 extract of SSM was carried out by chromatographic methods. Results: The extract of SSM showed potent antitumor effects in cultured cells of esophageal, gastric, and breast cancers in a concentration and time-dependent manner. The antitumor activity of SSM was seen in the mouse model with the intra-abdominal dissemination of gastric cancer cells. Its antitumor effect was not compromised by heating leaves at 100°C or drying them. The analysis of the extract revealed that the active antitumor phytoconstituent of SSM was an aggregate of polysaccharides. Conclusions: Our research demonstrated that SSM had a factor contributing to its antitumor effects in gastric cancers. In conclusion, intake of SSM, drinking decoction of dried leaves, is expected to be effective against gastric cancers.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Anti-cancer Effect of Saxifraga stolonifera Meerb

Nagata¹,

N²

2016

Clin Exp Pharmacol

View full text Add to dashboard Cite

show abstract

“…century ruin recorded Chinese medicinal plant names that indicated their use as medicines In 756, a total of 60 crude medicines, for example, pepper, cinnamon, licorice, rhubarb, betel nut palm, and croton, were contributed to Shosoin, where the treasure house that belongs to Todai-ji, Nara, and 38 of them remained (Figure 1 [4,6,7]. Ko-ho put emphasis on abdominal palpation and is main stream of Kampo [8].…”

Section: Introduction and Opening: Medical Systems And Recreationsmentioning

confidence: 99%

Culture, History and Applications of Medicinal and Aromatic Plants in Japan

Inoue¹,

Hayashi²,

Craker³

2017

Aromatic and Medicinal Plants - Back to Nature

View full text Add to dashboard Cite

Historically, the Japanese began to use aromatic and medicinal plants for ritual activities, food lavor, and treatment of their bodies. The exotic plants, new ideas, and culture associated with medicinal and aromatic plants were introduced to Japan from other countries, primarily via Korea. In this way, experience and knowledge of uses were accumulated, and applications of aromatic and medicinal plants were expanded. The oldest Japanese medicine "Wa ho" leads the way to folk medicine today, and traditional Japanese medicine (Kampo) has spread into modern use. The elegance tradition of "Kodo," an incense ceremony of Japan, was developed because of the use of aromatic incensed wood in sixteenth century as recreation. Paired along with this ceremony is the Japanese sa-do tea ceremony that the spirituality and esthetic sense are inherited to Japanese today.Japanese green tea is becoming popular in many countries due to the constituent, catechins, that medically treats vascular disease, several cancers, and type II diabetes. Today, the Japanese medical system has new direction, integrating medicine with the adoption of modern western and alternative medicine. Scientiic data must continue to be collected for interactions between the two medicinal systems for integrative medicine to be ideal for body, mind, and spirit of humans and nature.

show abstract

<i>In vitro</i> Antifungal Activity of Japanese Folk Herb Extracts against <i>Trichophyton rubrum</i>

et al. 2019

View full text Add to dashboard Cite

Folk herbs are vital to the Japanese health care system, with some being used to treat fungal skin infections. We tested folk herbs used in traditional Japanese medicine for in vitro antifungal activity against Trichophyton rubrum, the most common pathogen in patients with superficial dermatitis. Acetone, ethanol, methanol, water, and acetic acid extracts from 15 species of Japanese folk herbs Bi-wa, Aka-me-gashiwa, Ta-mushi-ba, Yomogi, Shi-so, Ku-ko, So-ba, Yama-momo, Kuro-mo-ji, Ichi-ji-ku, Kaki-no-ki, Kuwa-no-ki, Kusa-gi, Chimaki-zasa, and I-bukijya-kou-sou were evaluated for fungal growth inhibition, as measured by absorbance. Crude acetic acid extracts of Aka-me-gashiwa, Ta-mushi-ba, Yomogi, Ku-ko, Kaki-no-ki, and I-bukijya-kou-sou exhibited antifungal activity comparable to that of amphotericin B. Although the active compounds and underlying antifungal mechanisms are not known, the data contribute to the development of new and safe antifungal drugs, highlight new extraction methods for herbs, and support the traditional use of Japanese folk herbs against fungal infections.

show abstract

Herbal Drugs in Traditional Japanese Medicine

Cited by 3 publications

References 28 publications

Anti-cancer Effect of Saxifraga stolonifera Meerb

Anti-cancer Effect of Saxifraga stolonifera Meerb

Culture, History and Applications of Medicinal and Aromatic Plants in Japan

<i>In vitro</i> Antifungal Activity of Japanese Folk Herb Extracts against <i>Trichophyton rubrum</i>

Contact Info

Product

Resources

About