Herbal Complement Inhibitors in the Treatment of Neuroinflammation: Future Strategy for Neuroprotection

Kulkarni, Amod P.; Kellaway, Lauriston; Kotwal, Girish J.

doi:10.1196/annals.1352.020

Cited by 41 publications

(18 citation statements)

References 86 publications

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“…Traditional herbal medicines with neurotrophic and neuroprotective properties have been demonstrated to prevent neurodegeneration and neuroinflammatory diseases [6]. This suggests that these traditional medicinal herbs possess neuroprotective benefits through distinct and multiple mechanisms, including anti-inflammation [7–10]. Natural compounds specifically targeted to blocking microglial activation and therefore blocking the initiation of CNS inflammation may prove to be an effective therapy to prevent neurodegenerative and neuroinflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Leonoudakis

Rane

Angeli

et al. 2017

Mediators of Inflammation

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Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson's disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target to alleviate neurodegeneration. Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, has been reported to have potent biological activity and is used in the treatment of neurological conditions such as amyotrophic lateral sclerosis, poliomyelitis, and multiple sclerosis. In this study, we explored the underlying mechanisms of neuroprotection elicited by securinine, particularly its anti-inflammatory effects in glial cells. Our results demonstrate that securinine significantly and dose-dependently suppressed the nitric oxide production in microglia and astrocytic cultures. In addition, securinine inhibited the activation of the inflammatory mediator NF-κB, as well as mitogen-activated protein kinases in lipopolysaccharide- (LPS-) stimulated BV2 cells. Additionally, securinine also inhibited interferon-γ- (IFN-γ-) induced nitric oxide levels and iNOS mRNA expression. Furthermore, conditioned media (CM) from securinine pretreated BV2 cells significantly reduced mesencephalic dopaminergic neurotoxicity compared with CM from LPS stimulated microglia. These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Leonoudakis

Rane

Angeli

et al. 2017

Mediators of Inflammation

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“…These herbal ingredients along with other anti-inflammatory roles might be useful in treating neuroinflammation associated with CNS disorders. [87] Several stress-induced diseases, including the process of aging, may be related to accumulation of oxidative free radicals in different tissues. [88] Additionally, E. officinalis tannoids exerts a protective effect against neuroleptic-induced Tardive Dyskinesia which is likely to be due to its earlier reported antioxidant effects in rat brain areas, including striatum.…”

Section: Metabolic Syndromementioning

confidence: 99%

Emblica officinalis(Amla): A review of potential therapeutic applications

Bhandari¹,

Kamdod²

2012

Int J Green Pharm

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PHYTOCHEMISTRYE. officinalis is one of the most extensively studied plants and reports suggest that it contains tannins, alkaloids, and phenolic compounds. It has been reported that fruits of E. officinalis contains higher amount of vitamin C and considerably higher concentrations of most minerals, protein and amino acids like glutamic acid, proline, aspartic acid, alanine, cystine and lysine. vitamin C levels are more than those in oranges, tangerines, or lemons. Fresh pericarp of E. officinalis contains higher amount of hydrolysable tannins like emblicanin A and B, punigluconin, pedunculagin. Activity-directed fractionation and purification process identified phytochemicals present in E. officinalis. They have identified gallic acid, methyl gallate, corilagin, furosin and geraniin in E. officinalis by a chromatographic and spectroscopic method. Phytochemical investigations revealed that E. officinalis contains higher amount of flavonoid like quercetin. Fruits were also analyzed for their alkaloidal Emblica officinalis Gaertn. or Phyllanthus emblica Linn, commonly known as Indian gooseberry or Amla, is perhaps the most important medicinal plant in the Indian traditional system of medicine, the Ayurveda. Several parts of the plant are used to treat a variety of diseases, but the most important is the fruit. Many ailments are treated by the fruit which is used either alone or in combination with other plants. These include common cold and fever; as a diuretic, laxative, liver tonic, refrigerant, stomachic, restorative, alterative, antipyretic, anti-inflammatory, hair tonic; to prevent peptic ulcer and dyspepsia, and as a digestive. E. officinalis possesses antipyretic, analgesic, antitussive, antiatherogenic, adaptogenic, cardioprotective, gastroprotective, antianemic, antihypercholesterolemic, wound healing, antidiarrheal, antiatherosclerotic, hepatoprotective, nephroprotective, and neuroprotective properties as demonstrated in numerous preclinical studies. Furthermore, experimental studies have reported that E. officinalis and some of its phytochemicals also exhibit anticarcinogenic properties. E. officinalis is also reported to possess radiomodulatory, chemomodulatory, chemopreventive, free radical scavenging, antioxidant, anti-inflammatory, antimutagenic and immunomodulatory activities. These properties are efficacious in the treatment and prevention of cancer. This review summarizes the results related to these properties and also emphasizes the aspects that warrant future research establishing its activity and utility as a cancer preventive and therapeutic drug in humans.

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“…anticoagulant, coagulant (Osoniyi & Onajobi, 2003); neuroprotective (Kulkarni et al, 2005); causes nausea and vomiting (AbduAguye et al, 1986). hallucinogenic (Schultes, 1979).…”

Section: -21 Elephantopus Mollismentioning

confidence: 99%

Brazilian plants with possible action on the Central Nervous System: a study of historical sources from the 16th to 19th century

Giorgetti¹,

Rossi²,

Rodrigues³

2011

Rev. bras. farmacogn.

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Ethnopharmacological research when grounded on historic literature has for its objective retrieving traditional knowledge compiled throughout history by early cultures. The current study has used literature from the 16 th to the 19 th centuries to assess reports that include accounts of Brazil's native plants, with possible reports of disorders of the Central Nervous System (CNS). Visits were paid to 27 institutions located in four Brazilian states. This resulted in raising 529 publications, out of which 65 were read, revealing that 33 of them contained reports of plants exerting effects on CNS ailments. These plants' scientific names underwent an updating process. The updating process resulted in 788 species names (129 correct scientific names and their 659 synonyms) out of which 66 hold current ethnopharmacology, pharmacology studies and/or patent application. Coincidences among past and present data have been observed in 46 cases. Only three of them carried applications for patents all of which coincided with past uses. There have hardly been any studies whatsoever throughout the centuries for many of the species currently being studied. Although of very seldom use, research in ethnopharmacology and historic literature can be promising tools for the selecting of new pharmaco products, further to contributing with retrieving traditional knowledge.

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Herbal Complement Inhibitors in the Treatment of Neuroinflammation: Future Strategy for Neuroprotection

Cited by 41 publications

References 86 publications

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease

Emblica officinalis(Amla): A review of potential therapeutic applications

Brazilian plants with possible action on the Central Nervous System: a study of historical sources from the 16th to 19th century

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