Herba Epimedii: Anti-Oxidative Properties and Its Medical Implications

Sze, Stephen Cho Wing; Tong, Yao; Ng, Tzi Bun; Cheng, Chris Lok Yin; Cheung, Ho Pan

doi:10.3390/molecules15117861

Cited by 131 publications

(74 citation statements)

References 26 publications

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“…A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 7 pm every day during the study. The moments when the mice lost the vital signs (including temperature, heart rate and respiration) were recorded.…”

mentioning

confidence: 99%

Icariin, a natural flavonol glycoside, extends healthspan in mice

Zhang

Cai

Huang

et al. 2015

Experimental Gerontology

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mentioning

confidence: 99%

Icariin, a natural flavonol glycoside, extends healthspan in mice

Zhang

Cai

Huang

et al. 2015

Experimental Gerontology

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“…Therefore, new pharmacological strategies aimed at decreasing oxidative stress might represent potent therapeutic tools in the future. One of these could incorporate herbal medicine therapy (Sze et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect ofMentha longifoliain lipopolysaccharide-stimulated macrophages: Reduction of nitric oxide production through inhibition of inducible nitric oxide synthase

Karimian

Kavoosi

Amirghofran

2013

Journal of Immunotoxicology

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Mentha longifolia is an aromatic plant used in flavoring and preserving foods and as an antiinflammatory folk medicine remedy. The present study assessed the effects of M. longifolia extracts, including essential oil and crude methanol extract and its fractions (ethyl acetate, butanol and hexane), on nitric oxide (NO) production and inducible NO synthase (iNOS) mRNA expression in lipopolysaccharide (LPS)-stimulated J774A.1 cells using real-time polymerase chain reaction (PCR). The cytotoxic effects of the extracts on the cells were examined and noncytotoxic concentrations (50.2 mg/ml) were used to examine their effects on NO production and iNOS mRNA expression. Only the hexane fraction that contained high levels of phenolic and flavonoid compounds at concentrations from 0.05-0.20 mg/ml significantly reduced NO production in LPS-stimulated cells (p50.001). Real-time PCR analysis indicated the ability of this fraction at the same concentrations to significantly decrease iNOS as well as TNFa mRNA expression in the cells (p50.001). All extracts were able to scavenge NO radicals in a concentration-dependent manner. At concentrations greater than 0.2 mg/ml, total radicals were 100% scavenged. In conclusion, M. longifolia possibly reduces NO secretion in macrophages by scavenging NO and inhibiting iNOS mRNA expression, and also decreases TNFa pro-inflammatory cytokine expression, thus showing its usefulness in the inflammatory disease process. KeywordsInducible nitric oxide synthase (iNOS), macrophages, Mentha longifolia, nitric oxide (NO) History

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“…This could be due to the phytochemical constituents of the extract. Flavonoids [24] and saponins [25] have been shown to possess electron and hydrogen donating properties, respectively.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit

Agwaramgbo

Ilodigwe

Ajaghaku

et al. 2014

International Scholarly Research Notices

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Gongronema latifolium fruit has wide application in ethnomedicine, especially in maintaining healthy living and general body healing. We therefore investigated the antioxidant, immunomodulatory activities, and safety of its ethanol extract and fractions. The in vitro antioxidant activities of the extract and fractions were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) test while in vivo activities were determined using carbon tetrachloride (CCL4) induced oxidative stress. Cell and humoral mediated immune responses were also evaluated together with toxicity studies. The extract, ethyl acetate, and methanol fractions showed inhibition of DPPH radical with IC50s 120, 90, and 60 μg/mL, respectively. Methanol fraction at 200 mg/kg produced significant (P < 0.05) inhibition of lipid peroxidation (MDA conc. 1.2 μmol/L) compared to control (2.8 μmol/L). Both ethyl acetate and methanol fractions at 200 mg/kg produced significant (P < 0.05) phagocytic index of 0.021 and 0.025, respectively, compared with control (0.01). Significant (P < 0.05) elevations of white blood cells, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were noticed on the 91st day at higher doses. Generally, this study justified the traditional use of G. latifolium fruit for general body healing and maintenance of healthy living. Long term administration is safe on the haematological and biochemical systems especially at lower doses and its toxicity at higher doses is reversible.

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Herba Epimedii: Anti-Oxidative Properties and Its Medical Implications

Cited by 131 publications

References 26 publications

Icariin, a natural flavonol glycoside, extends healthspan in mice

Icariin, a natural flavonol glycoside, extends healthspan in mice

Anti-inflammatory effect ofMentha longifoliain lipopolysaccharide-stimulated macrophages: Reduction of nitric oxide production through inhibition of inducible nitric oxide synthase

Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit

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