Herb-induced liver injury: Systematic review and meta-analysis

Ballotin, Vinícius Remus; Bigarella, Lucas Goldmann; Brandão, Ajácio Bandeira de Mello; Balbinot, Raul Angelo; Soldera, Jonathan

doi:10.12998/wjcc.v9.i20.5490

Cited by 49 publications

(47 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Novel tools that would take into account this additional layer of complexity might be capable of predicting idiosyncratic DILI and help elucidate underlying mechanisms and susceptible phenotypes. Moreover, herb-induced liver injury, due to the excessive and prolonged consumption of herbal supplements and natural products, represent another emerging problem that often has an idiosyncratic character, and therefore should also be a part of the efforts undertaken to improve liver toxicity testing [ 364 , 365 ].…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Mihajlovic

Vinken

2022

IJMS

View full text Add to dashboard Cite

One of the major mechanisms of drug-induced liver injury includes mitochondrial perturbation and dysfunction. This is not a surprise, given that mitochondria are essential organelles in most cells, which are responsible for energy homeostasis and the regulation of cellular metabolism. Drug-induced mitochondrial dysfunction can be influenced by various factors and conditions, such as genetic predisposition, the presence of metabolic disorders and obesity, viral infections, as well as drugs. Despite the fact that many methods have been developed for studying mitochondrial function, there is still a need for advanced and integrative models and approaches more closely resembling liver physiology, which would take into account predisposing factors. This could reduce the costs of drug development by the early prediction of potential mitochondrial toxicity during pre-clinical tests and, especially, prevent serious complications observed in clinical settings.

show abstract

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Mihajlovic

Vinken

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Another patient experienced liver injury after taking 500 mg leaf powder every 2–3 days as a laxative [ 117 ]. In relation to other plants, such as green tea, HILI seems to be rare with aloe vera [ 118 ].…”

Section: Assessment Of Herbal Drugs and Their Interactionsmentioning

confidence: 99%

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Lippert

Renner

2022

JCM

View full text Add to dashboard Cite

Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John’s wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics.

show abstract

“…Herbal supplements are a growing cause of 'DILI' or more exactly, herb-induced liver injury (HILI) [12 && ]. In most cases, the injury is mainly hepatocellular but cases with small bile duct loss have been reported [13,14,15 & ]. One further example is 'kratom', or mitragynine, an herbal extract with analgesic and psychotropic, opioid-like, properties.…”

Section: Known Families New Playersmentioning

confidence: 99%

Drug-induced bile duct injury: new agents, new mechanisms

Scoazec

2021

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

Purpose of reviewDrug-induced bile duct injury can be caused by a long list of agents. In most cases, damage is because of T-cell-mediated idiosyncratic reactions. Recently, a number of new agents, including not only drugs but also herbal supplements, have been incriminated and new mechanisms of bile duct injury have emerged. This review will focus on these new data. Recent findingsNew members of drug families already known to be responsible for bile duct injury have been incriminated. New players have been identified, such as herbal supplements, like kratom, and recreational drugs, such as ketamine used outside the medical setting. Anticytokine monoclonal antibodies are rarely involved. In contrast, antineoplastic treatments are of growing concern, especially immune checkpoint inhibitors, which induce immune-related adverse effects because of the excessive stimulation of the immune system and its lack of regulation.

show abstract

Herb-induced liver injury: Systematic review and meta-analysis

Cited by 49 publications

References 90 publications

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Drug-induced bile duct injury: new agents, new mechanisms

Contact Info

Product

Resources

About