Herb–drug interactions: Review and assessment of report reliability

Fugh‐Berman, Adriane; Ernst, Edzard

doi:10.1046/j.0306-5251.2001.01469.x

Cited by 317 publications

(215 citation statements)

References 54 publications

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“…Systematic reviews were carried out recently to assess the published clinical evidence on interactions between herbal and conventional drugs. 26,27 As a result, many cases of suspected interactions were found. It was reported that warfarin was the most common drug and St. John's wort (Hypericum perforatum) was the most common herb involved.…”

Section: Discussionmentioning

confidence: 99%

Perceptions and attitudes of clinical oncologists on complementary and alternative medicine

Hyodo

Eguchi

Nishina

et al. 2003

Cancer

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BACKGROUND. The prevalence of complementary and alternative medicine (CAM)is increasing worldwide because of the growing public interest in natural or holistic therapies and because of the flow of information through the Internet. However, there is a lack of communication between cancer patients and their physicians on topics relating to CAM. The authors performed a cross-sectional survey to evaluate the perceptions and attitudes of Japanese clinical oncologists toward cancer CAM. METHODS.The CAM questionnaires were sent to 2118 clinical oncologists. The questionnaires gathered data on background (age, gender, years in practice, specialty, and knowledge of cancer CAM), perception (effectiveness/ineffectiveness, scientific evidence, and drug interactions), and attitude (experience with and response to CAM users). Questions about oncologists' perceptions and attitudes to CAM were limited to herbs and other natural products that were sold over the counter. RESULTS.One hundred sixty-six questionnaires were returned as undeliverable. Of the remaining questionnaires, 751 were returned (a response rate of 39%). Twothirds of the responders were surgical oncologists and most of the remaining responders were medical oncologists. The majority of oncologists (82%) believed that CAM products were ineffective against cancer. The main reason for this belief was a lack of reliable information (as cited by 85% of oncologists). Only 13% of oncologists had experienced CAM-associated disease improvement in their cancer patients. Of all the oncologists, 84% considered the possibility of drug interactions between anticancer drugs and CAM products. The majority of oncologists (80%) replied that they could neither promote the use of CAM products nor recommend quitting the products, when they were asked about the use of CAM products by cancer patients. I nterest in complementary and alternative medicine (CAM) has grown rapidly in the past decade. Some of the reasons for the increased interest include Internet marketing, dissatisfaction with mainstream medicine, and a desire of patients to be involved actively in their own health care, especially natural or holistic therapies. 1,2 The use of CAM has become prevalent in most industrialized countries. CONCLUSIONS. © 2003 American Cancer SocietyFor example, 48% of the population in Australia, 3 70% of the population in Canada, 4 42% of the population in the U.S., 5 31% of the population in Belgium, and 49% of the population in France 6 have used CAM at least once.By the 1990s, surveys showed that CAM was being used widely by cancer patients. The prevalence ranged from 7% to 64% of patients sampled in 26 studies conducted worldwide. 7 Complementary and alternative medicine in cancer medicine (e.g., Chinese traditional remedies, acupuncture, and other natural products, such as shark cartilage and beeswax-pollen mixtures) is widely available in Japan and Western countries. We found that 32% of cancer patients in Japan used CAM without having sufficient information. 8 There was a lack of commun...

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Section: Discussionmentioning

confidence: 99%

Perceptions and attitudes of clinical oncologists on complementary and alternative medicine

Hyodo

Eguchi

Nishina

et al. 2003

Cancer

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“…A survey of 44 of the leading dietary supplement manufacturers in 2003 revealed that only 10 of 15 respondents considered interactions to be an important issue, and only 2 allocated funds to study herbal-drug interactions (39). Poor reliability of the It was reported in a study that of one hundred and eight cases of suspected interactions studied, 68.5% were classified as 'unable to be evaluated', 13% as 'well-documented' and 18.5% as 'possible' interactions (40). One of the major reasons for this unreliability of reports of the clinical evidence on interactions between herbal and conventional drugs is the inherent scientific and clinical challenges in the use of herbal medicines.…”

Section: Challenges To Botanical-drug Interactions Researchmentioning

confidence: 99%

Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process

Obodozie¹

2012

Readings in Advanced Pharmacokinetics - Theory, Methods and Applications

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“…Interactions with other drugs during external use are not full-understood due to small and short systemic absorption. However, there is a case of 53-year-old female patient receiving angiotensin converting enzyme inhibitor (ACEI) with recurrent cough appearing only after application of topical capsaicin 0.075% cream which suggests that capsaicin may cause or exacerbate ACE inhibitor-induced cough [89].…”

Section: Contraindications Interactions With Other Drugsmentioning

confidence: 99%

Health-promoting properties of compounds derived from Capsicum sp. A review

Szydełko

Boguszewska-Czubara

2017

Herba Polonica

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S u m m a r yThis article presents multidirectional effects of capsaicin and its natural derivatives as well as natural and synthetic analogs in term of their therapeutic properties. Active agents present in various Capsicum genus plants exert analgesic, anti-inflammatory, antibacterial, antioxidant and gastroprotective effects. Furthermore, capsaicin positively influences the metabolism of lipids. Numerous research show that capsaicinoids inhibit proliferation and migration process of cancer cells, what makes them molecules of high interest in oncology. Among broad range of positive activities, we have focused only on those properties that have already found application in medicine or seemed to be the most probably used in the near future. Even if in low or single doses this compound has been reported successful in numerous therapies, the negative consequences of high doses or prolonged administration is also discussed in the review.

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Herb–drug interactions: Review and assessment of report reliability

Cited by 317 publications

References 54 publications

Perceptions and attitudes of clinical oncologists on complementary and alternative medicine

Perceptions and attitudes of clinical oncologists on complementary and alternative medicine

Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process

Health-promoting properties of compounds derived from Capsicum sp. A review

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