Herb-drug interaction between Shaoyao-Gancao-Fuzi decoction and tofacitinib via CYP450 enzymes

Li, Lin; Wang, Yuan; Shao, Sennan; Lin, Wen Jen; Huang, Dan; Dai, Yue; Xia, Yufeng

doi:10.1016/j.jep.2022.115437

Cited by 11 publications

(2 citation statements)

References 22 publications

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“…55 Another classic formula from the same work, the Shaoyao-Gancao-Fuzi Decoction, has a 3:1 ratio of Fuzi to Baishao, which has significant anti-inflammatory and analgesic effects. 56 The optimal ratio of Fuzi to Baishao for the treatment of RA requires further validation. In addition, although some of Fuzi and Baishao's targets have been confirmed through literature searches and molecular docking, many of the predicted targets still need to be validated.…”

Section: Discussionmentioning

confidence: 99%

Uncovering the Mechanism of Fuzi and Baishao in Treating Rheumatoid Arthritis Using Systems Pharmacology and Molecular Docking

Zhang,

Zhou,

Liu

et al. 2023

Future Integr Med

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Background and Objectives: Traditional Chinese Medicine has been implemented in clinical practice for thousands of years to treat rheumatoid arthritis (RA). Aconitum carmichaelii Debx (Fuzi) and Paeonia lactiflora Pall (Baishao) are a common herb-pair that is used in many herbal prescriptions to treat RA. However, the mechanism of Fuzi and Baishao for treating RA remains unclear. Here, we used a systems pharmacology and molecular docking approach to investigate the mechanism of Fuzi and Baishao in the treatment of RA. Methods:We obtained active compounds and targets through a database search and manual supplementation, followed by network construction and protein-protein interaction construction, which were then verified using molecular docking, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses. Results:We obtained 56 active compounds (including a duplicate compound), 102 targets, and 54 pathways using our systems approach. The results indicate that both herbs are involved in IL-17 and tumor necrosis factor signaling pathways through albumin, interleukin-6, glyceraldehyde-3-phosphate dehydrogenase, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, and other targets in the treatment of RA. After the combination, the number of targets, pathways, and specific targets on pathways increased. Conclusion:This research provides new insight into this particular herb pair and novel research directions for the treatment of RA with Fuzi and Baishao.

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Section: Discussionmentioning

confidence: 99%

Uncovering the Mechanism of Fuzi and Baishao in Treating Rheumatoid Arthritis Using Systems Pharmacology and Molecular Docking

Zhang,

Zhou,

Liu

et al. 2023

Future Integr Med

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“…It was reported that GL was one of the main ingredients of Shaoyao‐Gancao‐Fuzi decoction for inhibiting the activity of CYP3A4. [ 32 ] Han et al [ 33 ] reported that diammonium glycyrrhizinate could increase the bioavailability of omeprazole in rats by inhibiting CYP2C19 and CYP3A4 activities. As a result, whether GL will ameliorate DIOB‐induced hepatotoxicity raises our attention.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizin protects against diosbulbin B‐induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B

Yang,

Liu,

Chang

et al. 2023

J Biochem & Molecular Tox

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Diosbulbin B (DIOB), isolated from herbal medicine Dioscorea bulbifera L. (DB), could induce severe liver injury, and its toxicology was closely associated with CYP3A4‐mediated metabolic oxidation of furan moiety to the corresponding cis‐enedial reactive metabolite. Glycyrrhizin (GL), the major bioactive ingredient in licorice, can inhibit the activity of CYP3A4. Thus, GL may ameliorate hepatotoxicity of DIOB when GL and DIOB are co‐administrated. The study aimed to investigate the protective effect of GL on DIOB‐induced hepatotoxicity and the underlying mechanism. Biochemical and histopathological analysis demonstrated that GL alleviated DIOB‐induced hepatotoxicity in a dose‐dependent manner. In vitro study with mouse liver microsomes (MLMs) demonstrated that GL reduced the formation of metabolic activation‐derived pyrrole‐glutathione (GSH) conjugates from DIOB. Toxicokinetic studies showed that the pretreatment with GL caused the increase of AUCs and Cmax of DIOB in blood of mice, resulting in accelerating the accumulation of DIOB in the circulation. In addition, the pretreatment with GL alleviated DIOB‐induced hepatic GSH depletion. In summary, GL ameliorated DIOB‐induced hepatotoxicity, possibly related to the inhibition of the metabolic activation of DIOB. Thus, development of a standardized combination of DIOB with GL may protect patients from DIOB‐induced liver injury.

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Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review

Woon,

Tan,

Kwan

et al. 2024

Complementary Therapies in Medicine

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Herb-drug interaction between Shaoyao-Gancao-Fuzi decoction and tofacitinib via CYP450 enzymes

Cited by 11 publications

References 22 publications

Uncovering the Mechanism of Fuzi and Baishao in Treating Rheumatoid Arthritis Using Systems Pharmacology and Molecular Docking

Uncovering the Mechanism of Fuzi and Baishao in Treating Rheumatoid Arthritis Using Systems Pharmacology and Molecular Docking

Glycyrrhizin protects against diosbulbin B‐induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B

Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review

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