HER4 is a high affinity dimerization partner for all EGFR/HER/ErbB-family proteins
Pradeep Kumar Singh,
Soyeon Kim,
Adam W. Smith
Abstract:Human epidermal growth factor receptors (HER), also known as EGFR or ErbB receptors, are a subfamily of receptor tyrosine kinases (RTKs) that play crucial roles in cell growth, division, and differentiation. HER4 (ErbB4) is the least studied member of this family, partly because its expression is lower in later stages of development. Recent work has suggested that HER4 can play a role in metastasis through cell migration and invasiveness; however, unlike EGFR and HER2, the precise role that HER4 plays in tumor… Show more
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