According to GLOBOCAN's (Global Cancer Observatory) 2018 data, although gastric cancer incidence has decreased in recent years, gastric cancer is still the third leading cause of death from cancer worldwide (Bray et al., 2018). Annually, more than one million new cases are diagnosed (Bray et al., 2018), 110,000 of whom belong to Iran (Zendehdel, 2019). Metastasis is the most important factor behind the high mortality in patients suffering from gastric cancer (Oo et al., 2014). Two essential steps in metastasis are migration and invasion of tumoral cells, which consist of several interconnected steps including proliferation, detachment, circulation, transport, arrest in organs, adherence to the vessel wall, extravasation, the establishment of a microenvironment, and proliferation in distant organs (Li et al., 2014).Matrix metalloproteinases (MMPs) play an essential role in tumor growth, angiogenesis, and metastasis. They are a large family of zinc-dependent proteolytic enzymes that protelyse the extracellular matrix (ECM), regulate