HER-2/neu expression in cervical intraepithelial neoplasia and cervical carcinoma

Abstract

Objectives: 1) To study the expression of HER-2 in Cervical Intraepithelial Neoplasia (CIN) and Cervical carcinoma 2) To correlate expression of HER-2 with histological type, grade and stage of tumor. Methods: A total of 34 cases were collected during the period from October 2012 to June 2014. Clinical data was collected from medical records. The histopathology slides were analyzed and immunohistochemical (IHC) studies were done on suitable blocks with marker HER-2. Results: Thirty four specimens including 20 cases of squamous cell carcinoma (58.83%), 4 cases of adenocarcinoma (11.76%) and 10 cases of CIN (29.41%) were analyzed. HER-2 expression was noted in 7 out of 10 cases (70%) of CIN. Out of 12 poorly differentiated squamous carcinomas, 8 showed 3+ positivity and 4 showed 2+ positivity. Amongst the 5 moderately differentiated squamous carcinomas, 3 showed 3+ positivity, 1 showed 2+ positivity and 1 case showed 1+ positivity. Amongst the 3 well differentiated squamous carcinomas, 1 showed 1+ positivity and the remaining 2 showed 2+ positivity. Out of the 4 adenocarcinoma cases, 2 moderately differentiated carcinomas showed 3+ positivity and the remaining 2 well differentiated carcinomas showed 2+ positivity. All FIGO stage 4 cases showed 3+ positivity. Stronger HER-2 expression was also noted among cervical carcinoma cases with lymph node and parametrial involvement. Conclusions: The intensity of HER-2 expression increased progressively as grade of lesion increased and with presence of lymph node and parametrial involvement. All the cases under FIGO stage 4 showed strong (3+) HER-2 expression.

The Value of HER2 neu and EphA2 expressions in Gastric Adenocarcinoma Prognosis

“…This discrepancy may be due the use of different immunohistochemical clones, the number of examined cases or the selection criteria that implied further study on a larger scale. Tessa and Raghuveer [21] assessed the expression HER-2 in cervical cancer and proved that it was positively associated with increasing the grade of cancer, presence of lymph node metastases and parametrial spread which was in agree with our results. Our results were also compatible with Park et al [22] who studied Her2 amplification in colon cancer and reported that it was associated with higher rates of nodal metastasis and decreased patient survival.…”

Role of HER2/neu expression in premalignant and malignant lesions of uterine cervix

“…In the study done by Joseph et al, 2015, all cases of squamous cell carcinoma showed HER 2 expression, with 1+ positivity in 10% of cases, 2+ positivity in 35% of cases and 3+ positivity in 55% of cases. 5 In a study by Hale et al (1992), it was reported that HER 2 expression was found in 38% cases of squamous cell carcinoma, findings are quite similar to our study. 9 Gupta et al (2009), reported that 53.17% of cases of Squamous cell carcinoma showed HER 2 positivity.…”

“…In a study published by Protrka et al, 2007, expression of HER 2 in LSIL was found in 56.3% of cases and in HSIL it was reported in 81.8% of cases. 4 In a study by Joseph et al (2015), 70% of cases with CIN showed HER 2 positivity 5 . In a study conducted by Gupta et al (2009), 60% of CIN cases showed positivity of HER 2, most of them were of 1+ and 2+ positivity, none of them expressed 3+ positivity.…”

“…In our present study, overexpression of HER 2 was found in malignant lesions compared to premalignant lesions. In a study by Joseph et al (2015), it was observed that the expression of HER 2 was higher in malignant lesions when compared to the premalignant lesions. 5 They reported that progression of expression of HER 2 was gradual, when the spectrum of the lesion moves higher.…”

“…In a study by Joseph et al (2015), it was observed that the expression of HER 2 was higher in malignant lesions when compared to the premalignant lesions. 5 They reported that progression of expression of HER 2 was gradual, when the spectrum of the lesion moves higher. In studies reported by Gupta et al (2009), 6 and Lakshmi et al (1997) 8 similar findings were observed.…”