Hepcidin testing; establishing reference values for the Namibian blood donor population

Gonzo, Martin; Maramba, Aaron; Taylor, Gordon

doi:10.5348/ijbti-2017-28-oa-1

Cited by 4 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 98%

“…29 Similarly, reference range of 17.186 to 91.237 ng/mL for Namibian female blood donor population and 29 to 254 ng/mL was observed by previous studies. 30 Galesloot et al also established normal ranges for hepcidin in the Netherlands with median of 4.1 nM. 21 Hepcidin is master regulator of iron homeostasis through its effect on ferroportin; therefore, it gives an accurate estimate of iron bioavailability.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India

2021

View full text Add to dashboard Cite

Introduction Iron deficiency is one of the most common nutritional disorders in the world affecting young females of the reproductive age group. Indeed, an ideal screening test should be capable of identifying iron deficiency long before developing anemia. Henceforth, the present study was aimed to determine utility of hepcidin in iron deficiency and to see its correlation with different iron indices. Methods This cross-sectional study was conducted in the Department of Biochemistry, SGT Medical College Hospital and Research Institute, Budhera, Gurugram, Haryana, India. It included 200 nonpregnant female students aged between 18 and 25 years. Estimation of hepcidin was by enzyme-linked immunosorbent assay. Quantitative estimation of serum iron, total iron-binding capacity (TIBC), and transferrin saturation was done via semi-autoanalyzer. Statistical analysis was done using SPSS v22. Results The reference range of urinary hepcidin established in this study was 110 to 969 ng/mg creatinine (mean ± standard deviation 328.3 ± 195.07 ng/mg creatinine). Serum hepcidin and urinary hepcidin had a significant correlation with iron indices. Area under the curve of urinary hepcidin was obtained with best combination of diagnostic sensitivity (82.6%) and specificity (83.1%) at a cutoff value of > 15.7 ng/mL and ≤ 199 ng/mg, respectively. Conclusion Since ferritin, TIBC, transferrin saturation, and hepcidin each represent different aspects of iron metabolism, incorporating hepcidin in the present diagnostics and combined evaluation of these indices may accord enhanced clinical information. Hepcidin would help to stratify the vulnerable young healthy female population in early stages of iron deficiency and guide proper interventions to reduce morbidity.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India

2021

View full text Add to dashboard Cite

show abstract

“…Due to the unique nature of health resource allocation approaches, the standard treatment guidelines tend to be country specific. Some treatment interventions and diagnostic tests such as hepcidin levels may not be available 11 …”

Section: Discussionmentioning

confidence: 99%

“…The study showed that the patients who are routinely screened for IDA include symptomatic adults (70.6%), pregnant patients (68.8%), all patients during general medical check‐up (60.8%) and symptomatic children (58.8%). It is generally expected that pregnant women are screened for IDA as they are more vulnerable to IDA due to increased demands of iron by the growing foetus 11 . Screening all patients during general medical check‐up is ideal because some asymptomatic IDA cases may be identified sooner more so in pregnancy 13…”

Section: Discussionmentioning

confidence: 99%

An assessment of the adequacy of iron deficiency anaemia management in the Namibian private healthcare system

Gonzo

Nendongo

Mugweni

2020

Int J Lab Hematology

Self Cite

View full text Add to dashboard Cite

Introduction Anaemia, a condition characterized by reduced oxygen‐carrying capacity, is a widespread public health problem with major consequences for human health as well as social and economic development. Prompt and accurate diagnosis as well as effective management of iron deficiency anaemia (IDA) is important to prevent the undesired adverse clinical outcomes. Methods The purpose of the study was to assess the adequacy of IDA diagnosis and management within the Namibian private healthcare system. In this study, we used a quantitative, descriptive research design and data collection methods. The design was also nonexperimental in nature, employing a survey instrument to collect data. In total, 51 questionnaires were administered to private medical practitioners. Results The surveyed medical practitioners used different Standard Treatment Guidelines (STGs) in managing IDA cases, with the majority (76.5%) using the Namibia STGs. The other guidelines and their usage rates were as follows: World Health Organization guidelines (39.2%), Standard Treatment Guidelines and Essential Medicine List for South Africa (19.6%) and Essential Medicine List and Standard Treatment Guidelines for Zimbabwe (19.6%). Most of the medical practitioners used Namibian STGs although others used other treatment guidelines at their discretion. Conclusion The study concluded that medical practitioners follow different guidelines and reference documents when dealing with patients with suspected IDA. Adherence to a single reference document would enable standardization of clinical practice. Management of IDA in the Namibian private healthcare system could be improved. To ensure adequate IDA management and prompt resolution of iron deficiency anaemia, we recommended the need to review the Namibia Standard Treatment guidelines and to ensure that training on the guidelines is offered.

show abstract

Optimal serum ferritin level range: iron status measure and inflammatory biomarker

2021

View full text Add to dashboard Cite

This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and of inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomized study using phlebotomy in patients with peripheral arterial disease (PAD) offered unique insights into dual roles of serum ferritin both as an iron status marker and acute phase reactant. Robust positive associations between serum ferritin, interleukin 6 [IL-6], tissue necrosis factor-alpha (TNF-a), and high sensitivity C-reactive protein (hsCRP) were discovered. Elevated serum ferritin and IL-6 levels associated with increased mortality and with reduced mortality at ferritin levels < 100 ng/mL. Epidemiologic studies demonstrate similar outcomes. Extremely elevated ferritin and IL-6 levels also occur in individuals with high mortality due to SARS-CoV-2 infection. Disordered iron metabolism reflected by a high range of serum ferritin level signals disease severity and outcomes. Based upon experimental and epidemiologic data, we suggest testing the hypotheses that optimal ferritin levels for cardiovascular mortality reduction range from 20—100 ng/mL with % transferrin levels from 20–50%, to ensure adequate iron status and that ferritin levels above 194 ng/mL associate with all-cause mortality in population cohorts.

show abstract

Hepcidin testing; establishing reference values for the Namibian blood donor population

Cited by 4 publications

References 10 publications

Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India

Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India

An assessment of the adequacy of iron deficiency anaemia management in the Namibian private healthcare system

Optimal serum ferritin level range: iron status measure and inflammatory biomarker

Contact Info

Product

Resources

About