Hepcidin: SNP-Like Polymorphisms Present in Iron Metabolism and Clinical Complications of Iron Accumulation and Deficiency

Reichert, Cadiele Oliana; Cunha, Júlio Araujo Carneiro da; Levy, Débora; Maselli, LucianaMorganti Ferreira; Bydlowski, Sérgio Paulo; Spada, Celso

doi:10.5772/intechopen.69507

Cited by 3 publications

(6 citation statements)

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“…The Fe 3+ /Fe 2+ redox potential participates in a large number of protein complexes, especially those that involve oxygen reduction for adenosine triphosphate (ATP) synthesis and the reduction of DNA precursors. Iron is also a necessary component in the formation of molecules that bind and transport oxygen (hemoglobin and myoglobin) and for the activities of cytochrome enzymes, as well as in many enzymes that perform the redox process, functioning as electron carriers [ 83 , 84 , 85 ].…”

Section: Ferroptosismentioning

confidence: 99%

“…When necessary, iron stocks are mobilized and exported by ferroportin (FPN). This process is downregulated by hepcidin [ 83 , 84 , 85 ].…”

Section: Ferroptosismentioning

confidence: 99%

“…The recycling of iron by macrophages occurs through the phagocytosis of senescent erythrocytes and hemoglobin and the heme group of intravascular hemolysis. Once internalized in the macrophage, the heme group releases ferrous iron through the activity of the enzyme heme oxygenase, which can be exported to the extracellular medium by ferroportin or stored as ferritin [ 83 , 84 ].…”

Section: Figurementioning

confidence: 99%

“…When necessary, iron stocks are mobilized and exported by ferroportin (FPN). This process is downregulated by hepcidin [83][84][85]. Enterocytes, present in the duodenum and in the proximal portion of the jejunum, can absorb both ferrous iron (heme iron) and ferric iron (non-heme).…”

Section: Iron and Ferroptosismentioning

confidence: 99%

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Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

Reichert

Freitas

Sampaio-Silva

et al. 2020

IJMS

Self Cite

210

114

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Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential as a redox metal in several physiological functions. The brain is one of the organs known to be affected by iron homeostatic balance disruption. Since the 1960s, increased concentration of iron in the central nervous system has been associated with oxidative stress, oxidation of proteins and lipids, and cell death. Here, we review the main mechanisms involved in the process of ferroptosis such as lipid peroxidation, glutathione peroxidase 4 enzyme activity, and iron metabolism. Moreover, the association of ferroptosis with the pathophysiology of some neurodegenerative diseases, namely Alzheimer’s, Parkinson’s, and Huntington’s diseases, has also been addressed.

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Section: Ferroptosismentioning

confidence: 99%

“…When necessary, iron stocks are mobilized and exported by ferroportin (FPN). This process is downregulated by hepcidin [ 83 , 84 , 85 ].…”

Section: Ferroptosismentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Iron and Ferroptosismentioning

confidence: 99%

See 2 more Smart Citations

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

Reichert

Freitas

Sampaio-Silva

et al. 2020

IJMS

Self Cite

210

114

View full text Add to dashboard Cite

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“…While defect in guanine exon 2 at position 93 leads to a mutation in RNA [35], defect in Met50del from exon 2 causes a disorder in the expression of the active peptide and causes changes in reading frames. Another mutation, G71D, alters to amino acid 71, which is between (3-4) cysteine, which prevents linking with ferroportin [36].…”

Section: The Hamp Gene Mutationmentioning

confidence: 99%

Serum Hepcidin Hormone Level and Its Genes Polymorphism

Faraj¹,

Al-Abedy²

2021

Genetic Variation

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This chapter sheds light on hepcidin, historical view of hepcidin, and the time of its discovery in the first section. Then this chapter gives information about the genetic aspect and the importance of gene knowledge of hepcidin in explaining many disorders in human beings, supported by illustration figures. The regulation of iron in the human body as an essential function of hepcidin is discussed in this chapter. Examples of the genes of hepcidin (HAMP and HFE) are highlighted in detail as they are essential in regulating iron as well as discussing the genetic mutations that occur in these genes and their medical and clinical impacts for many diseases such as thalassemia. Finally, the inherited disorders related to hepcidin that lead to genetic diseases are discussed.

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Mini-Review on the Implications of Gene Polymorphism in the Metabolism of Xenobiotics

LUCA¹

2022

FARMACIA

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One of the most common medical issues in children and adults is accidental poisonings ranging from medicines to toxic substances such as alcohol and toluene and even metals like iron and lead. The way these substances are metabolised depends on a plethora of factors such as age, sex and even ethnicity. Besides these factors, there is one that holds an even more significant weight on how substances are metabolised -genes, or more precisely, alleles of specific genes. In recent years, genetic studies have significantly increased in number, and more and more genetic polymorphisms are being discovered and studied for their different effects compared to wild types. We performed a literature search on the subject comprising studies focusing on the most common substances in intoxications, as well as polymorphisms of CYP450 isoenzymes, HLA system and others. We obtained various studies on the subject highlighting differences in expression depending on the present allele, with some having diametral opposed effects while others being null. Thorough knowledge of these complex mechanisms is an important first step towards the development of tests to detect susceptibility to severe side effects and towards rapidly customising the therapeutic approach. RezumatUn aspect clinic sensibil, la copii și adulți, este otrăvirea accidentală cu diverse substanțe, de la medicamente la substanțe toxice cum ar fi alcoolul, toluenul sau chiar metale ca fierul și plumbul. Modul în care aceste substanțe sunt metabolizate este dependent de o varietate de factori cum ar fi vârsta, sexul sau etnia. Pe lângă aceștia, factorii genetici își pun amprenta considerabil asupra metabolismului substanțelor, fiind descoperite din ce în ce mai multe polimorfisme genetice. În acest studiu am analizat date din literatura de specialitate care se concentrează pe cele mai comune intoxicații, precum și diferite polimorfisme genetice. Aprofundarea acestor mecanisme complexe reprezintă un prim pas spre dezvoltarea de teste capabile să detecteze susceptibilitatea individuală la diferite substanțe, precum și personalizarea terapiilor.

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Hepcidin: SNP-Like Polymorphisms Present in Iron Metabolism and Clinical Complications of Iron Accumulation and Deficiency

Cited by 3 publications

References 168 publications

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

Serum Hepcidin Hormone Level and Its Genes Polymorphism

Mini-Review on the Implications of Gene Polymorphism in the Metabolism of Xenobiotics

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