Hepcidin Profile of Anemic Adolescent Schoolgirls in Indonesia at the End of 12 Weeks of Iron Supplementation

Htet, Min Kyaw; Dillon, Drupadi; Rosida, Azma; Timan, Ina Susianti; Fahmida, Umi; Thurnham, David I.

doi:10.1177/156482651403500202

Cited by 8 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The subjects from the study area were relatively healthy and as a result, the prevalence of inflammation was as low as 6%. This was in contrast with our previous work from Indonesia where the prevalence of inflammation was almost 40% among high school girls of the same age group [27].…”

Section: Discussioncontrasting

confidence: 96%

Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar

et al. 2019

Self Cite

View full text Add to dashboard Cite

Iron absorption was impaired in the presence of sub-clinical inflammation (SCI) and might hamper the effect of iron supplementation. The purpose of the study was to identify the influence of SCI on iron supplementation. A randomized, double-blinded, placebo-controlled experimental study was conducted among anaemic adolescent schoolgirls in Ayeyarwady region, Myanmar. A total of 402 schoolgirls were recruited from six schools screened from 1269 girls who were assigned into one of four groups: Folate group (2.5 mg of folate), Vitamin A group (15,000 IU of vitamin), Iron folate group (60 mg elemental iron and folate) and Iron, and vitamin A and folate group. Supplementation was done once a week for 12 weeks. Iron, vitamin A and inflammation were measured at the baseline, middle and endline. Changes in serum ferritin and body iron were significantly higher in the IFA and IFA + vitA among those without SCI. There was interaction between vitamin A and SCI on Hb changes. Analysis of GLM repeated measure showed interactions between treatment and SCI for hemoglobin and serum transferrin receptor. Those treated with vitamin A had better outcomes when there was SCI. Inflammation accompanied a negative effect on iron supplementation and vitamin A improved efficacy of iron supplementation in the presence of SCI.

show abstract

Section: Discussioncontrasting

confidence: 96%

Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…[26] and Ht et al . [28] reported higher CRP levels in adolescents similar to our observations in the Maharashtra state of India.…”

Section: Discussionsupporting

confidence: 88%

“…A study from Nepal showed a mean CRP of 0.19 mg/L in 13‐ to 19‐year‐old girls ( N = 112), which is much lower than our population [27]. A study by Htet and associates reported much higher CRP levels in anaemic adolescent girls from Indonesia [28]. Median CRP was 5.0 mg/L (95% CI 4.9 to 5.7, N = 83), and 35% girls had higher AGP (>1 g/L) suggesting subclinical inflammation.…”

Section: Discussionmentioning

confidence: 69%

Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross‐sectional study

Ahankari

Kabra

Tata

et al. 2020

Tropical Med Int Health

View full text Add to dashboard Cite

Objective This study tested the hypothesis that systemic inflammation is inversely associated with haemoglobin levels in adolescent girls in India. Methods The study population consisted of adolescent girls aged between 10 and 19 years living in a remote rural region in Maharashtra State, India. Data were collected on anthropometric measures, and a venous blood sample was taken and tested for complete blood count and C‐reactive protein (CRP). Results Of 679 individuals who were invited to the research site to participate, data were available from 401 participants giving a response rate of 59%. Median blood CRP was 1.26 mg/l (Range 0.00 to 26.33), and 167 (41.6%) participants had CRP level < 1.0 mg/l. The mean haemoglobin was 12.24 g/dl (standard deviation [SD] 1.51), and the mean total white blood cells (WBC) count was 9.02 × 103/μl (SD 2.00). With each g/dl increase in blood haemoglobin, the risk of having an elevated CRP of ≥ 1 mg/l increased with an odds ratio of 1.16 (95% CI 1.01 to 1.33, P = 0.03). Total WBC count was also positively associated with blood haemoglobin, increasing by 0.24 × 103/μl (95% CI 0.11 to 0.37, P < 0.001) per g/dl increase in haemoglobin. Both analyses were adjusted for age. Conclusions In this population, blood haemoglobin levels were positively associated with two measures of systemic inflammation, contrary to the primary hypothesis being tested. Other unmeasured environmental exposures may modify haemoglobin levels in this population. Understanding this observation may help design better public health interventions to improve the well‐being of adolescent girls in India.

show abstract

“…Another US-based study randomized adolescents to a health clinic-based behavioural nutrition intervention which emphasized a diet high in fruits, vegetables and low-fat dairy; this intervention increased adolescents' intakes of fruits, potassium and magnesium significantly, and decreased total fat consumption (37) . Additionally, Agustina and Prafiantini (27) ; Bansal et al (25) ; Beasley et al (22) ; Februhartanty et al (19) ; Htet et al (20) ; Jus'at et al (28) ; Lassi et al (23) ; Lassi et al (18) ; Salam et al (17) ; Soekarjo et al (21) ; WHO (24) ; Vir et al Angeles-Agdeppa et al (32) ; Friis et al (31) ; Lassi et al (18) ; Mwaniki et al (30) ; Sitompul et al (33) Nutrition education/diet counselling Stunting* Thinness* Overweight* Anaemia †…”

Section: Micronutrient Supplementationmentioning

confidence: 99%

“…Iron and folic acid supplementation. Moderate-quality evidence, largely based on small-scale programmes in LMIC, suggests that weekly IFA supplementation (60 mg Fe/d with 400 µg folic acid/d) among adolescents leads to a significant reduction in anaemia among both girls and boys (17)(18)(19)(20)(21)(22)(23)(24)(25)(26) . In particular, recent evidence pooling data from twenty-three trials among adolescents in low-, middle-and high-income countries showed that IFA significantly reduced anaemia and improved serum Hb levels (18) .…”

Section: Micronutrient Supplementationmentioning

confidence: 99%

Potential interventions targeting adolescent nutrition in Indonesia: a literature review

Oddo¹,

Roshita²,

Rah³

2018

Public Health Nutr.

View full text Add to dashboard Cite

ObjectiveThe present study aimed to take stock of nutrition interventions that warrant consideration as a minimum package of interventions in Indonesia to improve four key nutrition indicators for adolescents: stunting, thinness, overweight and anaemia.DesignWe conducted a review of the peer-reviewed literature published between 1995 and 2017 on nutrition-specific and nutrition-sensitive interventions that target adolescents in Indonesia. The search to identify studies was conducted in PubMed, Google Scholar and EMBASE, using key search terms. We also explored programmatic and policy documents from the grey literature as they related to adolescents and/or Indonesia. Our search yielded thirty-five peer-reviewed articles and programmatic documents.SettingIndonesia.SubjectsAdolescent girls and boys.ResultsThere is very limited evidence on the impact of interventions specifically among adolescents in Indonesia. Nevertheless, findings from our review suggest the minimum package of interventions in Indonesia could include the following nutrition-specifc interventions: (i) iron–folic acid supplements, paired with antihelminths delivered at scale via school-based platforms and through health centres; and (ii) diet counselling and nutrition education provided through school-based platforms, adolescent youth centres/peer education and technology-based platforms. The minimum package could also include the following nutrition-sensitive interventions: (i) improving access to reproductive health services; and (ii) increasing the coverage of interventions designed to increase school attendance.ConclusionsProgrammes and policies targeting adolescent nutrition are relatively new and coverage is low. To improve the nutritional status of this vulnerable population, additional evaluations of adolescent programming and surveillance data on adolescents are needed.

show abstract

Hepcidin Profile of Anemic Adolescent Schoolgirls in Indonesia at the End of 12 Weeks of Iron Supplementation

Cited by 8 publications

References 28 publications

Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar

Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar

Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross‐sectional study

Potential interventions targeting adolescent nutrition in Indonesia: a literature review

Contact Info

Product

Resources

About