Hepcidin and Iron Deficiency in Pre-Kidney Transplant Patients

Sancho, A.; Pastor, M.C.; Troya, Maribel; Bonal, Jordi; Bayés, Beatriz; Morales‐Indiano, Cristian; Lauzurica, Ricardo; Romero, R.

doi:10.1016/j.transproceed.2009.06.089

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…This commonly seen paradox of high serum ferritin and low TSAT has made it desirable to look for a substitute of iron markers to predict better iron status of the patient [8] .The diagnosis of iron deficiency using these markers is unproductive, as they can be affected by variables such as age, sex, inflammation and nutritional factors. Sancho et al [33] concluded that determining hepcidin concentrations together with conventional markers associated with iron metabolism improved the identification of patients with iron deficiency by 26.1%. In this study in a cohort of stable prevalent HD patients, hepcidin levels were shown to have insignificant weak positive association with iron stores (as reflected by ferritin levels) and significant positive association with CRP as a marker of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Elmenyawi¹,

Hassan²,

Said³

2017

Egyptian Journal of Hospital Medicine

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Objective: Uremia is a state of heightened inflammatory activation. This might have an impact on several parameters including those used in the management of anemia as ferritin, serum iron, transferrin saturation, C-reactive protein (CRP) and hepcidin levels. In spite of this complexity the existing data indicate that hepcidin has an advantage over ferritin in guiding treatment of anemia in patients with chronic kidney disease (CKD) as it directly reflects iron availability and the status of iron homeostasis. Aim of the study: was to determine serum hepcidin levels in maintenance haemodialysis (HD) patients and to investigate its relation to ferritin and markers of inflammation as C-reactive protein. Subjects and methods: This study was conducted on 40 maintenance haemodialysis patients and 20 agematched apparently healthy controls from October 2015 till February 2016 at the Haemodialysis Departement, National Institute of Urology and Nephrology (NIUN). Creatinine, albumin, hemoglobin, leucocytic count, CRP, hepcidin and ferritin were measured. Results: Serum ferritin and hepcidin levels were significantly higher in HD patients compared with controls (825.67 ± 956.52 ng/ml and 9.2 ± 4.2 ng/ml vs 85.1± 63.35 ng/ml and 0.75 ± 0.39 ng/ml respectively) (p< 0.001).There was significant difference in CRP in HD patients compared with controls (4.28 ± 3.7mg/L vs 1.35±1.04mg/L respectively)(p<0.05).There were insignificant positive weak correlations between serum levels of hepcidin and ferritin (r = 0.05, P = 0.74). Conclusion: Serum hepcidin levels are increased in HD patients and, hence, could be used in the evaluation of anemia in such patients. Serum hepcidin provides useful information about the level and availability of iron during inflammation as compared with traditional markers of iron status. Availability of the ELISA assay for serum hepcidin will facilitate the routine measurement of hepcidin in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Elmenyawi¹,

Hassan²,

Said³

2017

Egyptian Journal of Hospital Medicine

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“…Since iron indices may be misleading in diagnosis of iron deficiency in HD patients, detection of other markers may be of a value. Sancho et al concluded that "determining hepcidin concentrations together with conventional markers associated with iron metabolism improved the identification of patients with iron deficiency by 26.1%" [23].…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactoferrin Administration on Serum Iron Status of Children on Regular Hemodialysis

Turky

Saad

Badraia

et al. 2022

JAMMR

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Background: This study aimed to evaluate the effect of lactoferrin administration on serum iron status of children on regular hemodialysis. Methods: This case-controlled study was carried on 60 children with end stage renal disease on regular hemodialysis and 30 healthy children served as a control group. Patients were classified into 2 groups, group A: 30 patients received oral lactoferrin supplementation 100 mg for 3 months and group B: 30 patients received oral lactoferrin supplementation plus oral iron 5mg/kg/day for 3 months. Serum ferritin, transferrin saturation (TSAT), serum hepcidin and IL6 were measured before and after supplementation Results: Serum ferritin was significantly higher in patient groups compared to controls before the supplementation (P <0.001) but significantly decreased after supplementation (P= <0.001). No significance difference between patient groups in serum ferritin levels before or after the supplementation (P=0.778, P=0.763) respectively. TSAT was significantly lower in patients groups compared to controls before the supplementation (p<0.001) but showed significant decrease after supplementation in group A (P=0.036) and significant increase in group B after the supplementation (P<0.001). TSAT was significantly increased in group B compared to group A (P<0.001). Serum hepcidin and serum interleukin 6 levels were higher in patients than controls before supplementation but significantly decreased at the end of the study in patient groups. . There were positive correlations between serum hepcidin and interleukin 6, CRP, and ferritin levels but a negative correlation with hemoglobin and TSAT. There was a positive correlation between serum IL-6 and both CRP and ferritin but a negative correlation between IL-6 and both Hb and TSAT. Conclusions: Oral lactoferrin was not able to maintain iron status in HD children while Lactoferrin plus oral iron was effective in treating iron deficiency in HD patients.

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“…These conventional markers had some limitations as it can be affected by age, gender, inflammation, and nutritional factors. It was reported that the determination of hepcidin concentrations together with conventional markers of iron metabolism could improve the identification of patients with iron deficiency by 26.1% [29].…”

Section: Discussionmentioning

confidence: 99%

Hepcidin and its Related Hematological Biomarkers of Anemia in Children on Hemodialysis: Role of Carnitine Deficiency

El-Toukhy

Fadel

Elshamaa

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Anemia is one of the most common complications in end-stage renal disease (ESRD) patients. Hepcidin is a hormone that regulates iron homeostasis in patients with ESRD. Carnitine deficiency is commonly seen in hemodialysis (HD) patients. AIM: This study aimed to investigate the relationship between hepcidin and inflammatory and other anemia markers in children with ESRD and to evaluate the association of carnitine deficiency with anemia in these patients. SUBJECTS AND METHODS: Thirty pediatric patients with ESRD undergoing HD, and thirty healthy, age- and sex-matched children served as controls were included in the study. Serum levels hepcidin, iron status, high-sensitivity C-reactive protein, and total carnitine were measured. RESULTS: Statistically significant increases in serum levels of hepcidin (100.7 ± 0.99 ng\ml vs. 77.43 ± 0.8 ng\ml, p = 0.000), was found in HD children as compared to healthy controls. Statistically significant increase in serum levels of hs-CRP (3.94 ± 0.19 mg/l vs. 1.36 ± 0.07 mg/l, p = 0.04) was found in HD children as compared to healthy controls. However, serum levels of carnitine (29.59 ± 2.46 μmol/L vs. 36 ± 2.39 μmol/L, p = 0.000) showed statistically significant decreases in HD children as compared to healthy controls positive correlation was found between hepcidin and hs-CRP (r = 0.059, p = 0.042). Furthermore, a positive correlation was present between serum carnitine levels and serum iron levels (r = 0.651, p = 0.042). CONCLUSION: Serum hepcidin may be a more useful biomarker of functional iron deficiency in children on HD. The efficacy of carnitine treatment for children on HD with carnitine deficiency and its effect on anemia needs to be studied.

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Hepcidin and Iron Deficiency in Pre-Kidney Transplant Patients

Cited by 6 publications

References 12 publications

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Relationship between Hepcidin, Ferritin and C-Reactive Protein in Hemodialysis Patients

Effect of Lactoferrin Administration on Serum Iron Status of Children on Regular Hemodialysis

Hepcidin and its Related Hematological Biomarkers of Anemia in Children on Hemodialysis: Role of Carnitine Deficiency

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