Hepcidin - A novel biomarker with changing trends

Kali, Arunava; Charles, Marie Victor Pravin; Seetharam, Rathan Shetty Kolkebail

doi:10.4103/0973-7847.156333

Cited by 43 publications

(25 citation statements)

References 35 publications

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“…Hepcidin is a peptide hormone with 25 amino acids, responsible for the regulation of the hemostasis of iron. The hepcidin gene (hepcidin antimicrobial peptide (HAMP)) is located on chromosome 19 [ 55 ]. The main source of the synthesis of hepcidin is the liver.…”

Section: Discussionmentioning

confidence: 99%

“…The main source of the synthesis of hepcidin is the liver. Extra-hepatic production of hepcidin was described in the heart, kidney, retina, monocytes and macrophages, alveolar cells, adipocytes, pancreatic β-cells and bile [ 16 , 55 , 56 ]. The hepcidin levels increase during inflammation, primarily as a result of increased IL-6 and IL-1 [ 11 , 57 ] levels by activating the signal transducer and activator of transcription-3 (STAT3) signaling to hepcidin gene promoter ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis

Silva-Vaz

Abrantes

Castelo‐Branco

et al. 2020

IJMS

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Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that, when classified as severe, is associated with high morbidity and mortality. Promptly identifying the severity of AP is of extreme importance for improving clinical outcomes. The aim of this study was to compare the prognostic value of serological biomarkers, ratios, and multifactorial scores in patients with acute biliary pancreatitis and to identify the best predictors. In this observational and prospective study, the biomarkers, ratios and multifactorial scores were evaluated on admission and at 48 h of the symptom onset. On admission, regarding the AP severity, the white blood count (WBC) and neutrophil–lymphocyte ratio (NLR), and regarding the mortality, the WBC and the modified Marshall score (MMS) showed the best predictive values. At 48 h, regarding the AP severity, the hepcidin, NLR, systemic inflammatory response index (SIRI) and MMS and regarding the mortality, the NLR, hepcidin and the bedside index for severity in AP (BISAP) score, showed the best predictive values. The present study enabled the identification, for the first time, of SIRI as a new prognostic tool for AP severity, and validated hepcidin and the NLR as better prognostic markers than C-reactive protein (CRP) at 48 h of symptom onset.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis

Silva-Vaz

Abrantes

Castelo‐Branco

et al. 2020

IJMS

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“…Our results would suggest not, since an increased hepcidin production by the liver is associated to a decrease, rather than an increase in iron transfer. Increased levels of hepcidin are associated with inflammation [41]. The mRNA up-regulation of hepcidin, even if only at very low levels, could be reflective of inflammation.…”

Section: Discussionmentioning

confidence: 99%

The effect of amino acid deprivation on the transfer of iron through Caco-2 cell monolayers

Roussel

Stevens

Cottin

et al. 2017

Journal of Trace Elements in Medicine and Biology

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Iron is a key trace element, involved in different processes of metabolism such as respiration, energy production, DNA synthesis and cell proliferation. However, given its capacity for changing valency, it also has potential for toxicity at excessive levels. Consequently, a tight regulation of absorption and excretion has evolved.Many studies have examined the way other nutrients and micronutrients interact with iron metabolism. These interactions can be both direct and indirect. For example, vitamin C or cysteine and histidine can bind iron atoms, increasing bioavailability and increasing iron absorption [1][2][3]. Alternatively, copper deficiency can negatively impact iron flux from the liver by decreasing the expression of ceruloplasmin, required for iron incorporation into transferrin [4]. Nutrients that alter expression of some of the iron regulatory pathways can also modify iron metabolism [5]. These compounds have proved particularly valuable in elucidating the regulation of iron.Dietary iron is found in two forms; haem iron and non-haem (inorganic) iron. These two forms of iron have separate absorption mechanisms across the gut [6-8]. Haem iron is transported either by a haem AbstractIron (Fe) metabolism is modified by many nutritional factors. Amino acids (AA) play a central role in various biological processes, such as protein synthesis and energy supply. However, the influence of AA status on iron metabolism has not been investigated. Here, we test whether AA alters iron metabolism in an intestinal cell model. Both Fe uptake and transfer across the cell monolayer were significantly increased by non-essential AA deficiency (both p < 0.001) while only Fe transfer was increased by essential AA deficiency (p < 0.0001). Both essential and non-essential AA deficiency decreased DMT1 (±IRE) exon1A mRNA expression (respectively p = 0.0007 and p = 0.006) and increased expression of ferritin heavy chain. DMT1 + IRE (also expressing exon1A or 1B) mRNA levels were decreased by essential AA deficiency (p = 0.012). The mRNA levels of total DMT1 were also decreased by essential, but not non-essential, AA deficiency (p = 0.006). Hepcidin levels were increased significantly by non-essential amino acid deprivation (p = 0.047). Protein levels of ferroportin and/or ferritin heavy chain were not altered by AA deficiency, suggesting that they had no effect on Fe efflux or storage in the cell, though iron content of ferritin could be increased. Our data demonstrate, for the first time, that AA status affects iron transport and the expression of genes related to iron metabolism in Caco-2 cells, although the changes observed are not sufficient to explain the alteration in iron transport. We hypothesise that the effect on Fe transfer is mediated through an increased movement across the cell layer, rather than transfer across the cell membranes.

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“…Hepcidin is a peptide of mostly hepatic origin involved in iron metabolism. Increased serum hepcidin levels were observed in neoplastic diseases, in ammation and sepsis [19]. Its expression is suppressed by iron de ciency, anaemia, and hypoxia, but induced by iron overload, in ammatory stimuli and LPS [20].…”

Section: Hepcidinmentioning

confidence: 99%

The role of Plasminogen Activator Inhibitor 1 in predicting sepsis-associated liver dysfunction: an observational study

Woźnica-Niesobska

Leśnik

Woźnica³

et al. 2020

Preprint

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Background Sepsis-associated liver dysfunction (SALD) is associated with poor prognosis and an increased mortality in Intensive Care Unit (ICU). Bilirubin is one of the components of Sequential Organ Failure Assessment (SOFA) used in Sepsis−3 criteria. Hyperbilirubinemia is a late and non specific symptom of liver dysfunction. The aim of the study was to identify plasma biomarkers, which could be used for an early diagnosis of SALD. Methods A single-centre, prospective observational study was conducted in the ICU of Wroclaw University Hospital. Plasma biomarkers - prothrombin time, INR, antithrombin III, bilirubin, aspartate transaminase (AST), alanine transaminase, albumin, endothelin-1, hepcidin, plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex and interferon-gamma inducible protein 10 kDa were analysed. Plasma samples were obtained from eligible septic patients within 24 hours after having developed sepsis/septic shock. Enrolled patients were followed for 14 days for developing SALD and 28 days for overall survival. Results Seventy-nine patients were enrolled into the study, and 24 (30,4%) of them developed SALD. PAI-1 with cut-off value of 9 ng/ml was shown to be a good predictor of SALD (AUC = 0,727, sensitivity 79,2%; specificity 41,8%; accuracy 53,2%) and of 28-day survival in patients with sepsis/septic shock (log rank test, p = 0,00091). In combination with AST it was also useful in predicting 28-day survival (log rank test, p = 0,00242). Conclusions Sepsis-associated hyperbilirubinemia is frequent, but bilirubin is a late and non specific marker of SALD. Measuring PAI-1 serum levels at the onset of sepsis/ septic shock may be useful in predicting the development of SALD. A combination of PAI-1 and AST predicts better the 28-day survival, than PAI-1 alone, but due to low cut-off values of AST it might not be clinically significant.

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Hepcidin - A novel biomarker with changing trends

Cited by 43 publications

References 35 publications

Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis

Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis

The effect of amino acid deprivation on the transfer of iron through Caco-2 cell monolayers

The role of Plasminogen Activator Inhibitor 1 in predicting sepsis-associated liver dysfunction: an observational study

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