HepCare Europe—A service innovation project. HepCheck: Characteristics of the patient population with active infection as defined by HCV RNA

Avramovic, Gordana; Oprea, Cristiana; Surey, Julian; Story, Alistair; Macı́as, Juan; Cullen, William R.; Iglesias, María; Hugh, Tina Mc; Crowley, Des; Naughton, Anna Marie; Horan, Aidan; Ianache, Irina; Lazar, Stefan; I, Popa; Menezes, Dee; Lambert, John S.

doi:10.1016/j.ijid.2019.11.027

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Type 2 DM and CKD have a considerable impact on follow-up medical care, labor, and economy and are associated with poor prognosis and management challenges; hence, disease prevention, screening, and clinical management strategies are urgently required. 12,13 Our results showed that the average levels of glucose, eAG(GA), and eAG(HbA1c) were significantly higher in the VH group than in the control group, indicating that VH is closely associated with the occurrence of type 2 DM.…”

Section: Discussionmentioning

confidence: 63%

Blood Glucose and Renal Function Evaluation in Patients with Viral Hepatitis

Hsu¹,

Yang²,

Liao³

et al. 2021

DMSO

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Purpose: To evaluate the blood glucose and renal function, determine the prevalence of hyperglycemia/diabetes mellitus (DM) and renal disease (nephropathy), and investigate the association between hyperglycemia/DM and renal disease in patients with viral hepatitis (VH). Patients and Methods: A total of 491 subjects were included in the study. Patients with VH were further divided into the hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and HBV-HCV co-infection subgroups. Fasting blood glucose, glycated hemoglobin (HbA1c), glycated albumin (GA), glutamic oxaloacetic transaminase (GOT), creatinine (Cr), and cystatin C (Cys C) levels were measured. Urine microalbumin levels were also assessed. Formulas for estimated average glucose calculated using glycated albumin (eAG(GA)), estimated average glucose calculated using HbA1c (eAG(HbA1c)), and estimated glomerular filtration rate calculated using cystatin C (eGFRcys) were used to evaluate the average glucose and renal function. Results: The prevalence of hyperglycemia/DM and renal disease was significantly higher in the VH group, especially in the HCV subgroup. The prevalence of renal disease was significantly higher in patients with VH with eAG(GA) ≥200 mg/dL. Conclusion:Our study used multiple parameters to evaluate blood glucose and renal function in patients with VH and found that hyperglycemia/DM and renal disease are closely associated with VH, especially in subjects with HCV infection. Patients with VH, especially those with HCV infection and hyperglycemia/DM, were particularly vulnerable to renal disease.

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Section: Discussionmentioning

confidence: 63%

Blood Glucose and Renal Function Evaluation in Patients with Viral Hepatitis

Hsu¹,

Yang²,

Liao³

et al. 2021

DMSO

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“…Previous estimations of HCV prevalence in homeless PWID across Europe are commonly based on HVC antibodies and range from 35% to 70% [ 21 ]. One cohort study conducted in Europe among homeless individuals, prisoners, and PWID showed a HCV RNA prevalence ranging from 9% to 43% [ 22 ]. The proportion of HCV RNA positivity among PWID in our study is 18%, which is somewhat lower compared to that of PWID in the European Union region, which ranges between 26% and 90% (Studies 8, 16–19 in: [ 23 ]).…”

Section: Discussionmentioning

confidence: 99%

A Feasibility Study to Increase Chronic Hepatitis C Virus RNA Testing and Linkage to Care among Clients Attending Homeless Services in Amsterdam, The Netherlands

Grient¹,

Schatz²,

Santen

et al. 2021

Diagnostics

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People who inject drugs (PWID) are disproportionately affected by hepatitis C virus (HCV) infections and are frequently homeless. To improve HCV case finding in these individuals, we examined the feasibility of rapid HCV RNA testing in homeless services in Amsterdam. In 2020, we provided a comprehensive service to homeless facilities, which included workshops on HCV for personnel, a “hepatitis ambassador” at each facility, a rapid, onsite HCV RNA fingerstick test service, and assistance with linkage to care. Risk factors for HCV RNA-positive status were examined using Bayesian logistic regression. Of the 152 participants enrolled, 150 (87% men; median age: 47 years) accepted rapid HCV testing. Seven tested HCV RNA positive (4.7%, 95%CrI = 1.31–8.09; 7/150). Of these, five (71%) were linked to care, of whom four (57%, 4/7) initiated treatment and one (14%, 1/7) delayed treatment due to a drug–drug interaction. Of these four people, two completed treatment (50%), of whom one (25%) achieved sustained virologic response after 12 weeks. HCV RNA-positive individuals were more likely to originate from Eastern Europe (posterior-odds ratio (OR) = 3.59 (95% credible interval (CrI) = 1.27–10.04)) and to inject drugs (ever: posterior-OR = 3.89 (95% CrI = 1.37–11.09); recent: posterior-OR = 3.94 (95% CrI = 1.29–11.71)). We identified HCV RNA-positive individuals and linkage to care was relatively high. Screening in homeless services with rapid testing is feasible and could improve HCV case finding for PWID who do not regularly attend primary care or other harm reduction services for people who use drugs.

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“…HepCare Europe is a project co-funded by the European Commission whose aim was to create and implement a model of HCV management (screening, linkage to care and treatment) for patients from key populations, through outreach to the community and integrated primary and secondary care services. It is a consortium between 5 institutions from 4 countries (Ireland, United Kingdom, Spain and Romania) (6).…”

Section: Introductionmentioning

confidence: 99%

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2019

Ro J Infect Dis.

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HepCare Europe—A service innovation project. HepCheck: Characteristics of the patient population with active infection as defined by HCV RNA

Cited by 10 publications

References 22 publications

Blood Glucose and Renal Function Evaluation in Patients with Viral Hepatitis

Blood Glucose and Renal Function Evaluation in Patients with Viral Hepatitis

A Feasibility Study to Increase Chronic Hepatitis C Virus RNA Testing and Linkage to Care among Clients Attending Homeless Services in Amsterdam, The Netherlands

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