Hepatotoxicity Secondary to Levofloxacin Use

Panahi, Ladan; Surani, Salim; Udeani, George; Patel, N. K.; Sellers, Jacob

doi:10.7759/cureus.15973

Cited by 4 publications

(7 citation statements)

References 15 publications

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“…Although we did not observe a concurrent rise in total bilirubin and alkaline phosphatase, our patient’s baseline characteristics fit the patients described in these case studies. Previous case studies raised other factors affecting liver injury, including impaired renal function and a lack of renally dosing medications; however, our patient’s glomerular filtration rate was >60 mL/min [ 14 ]. Medications may cause hepatotoxicity, although this was a less likely cause for our patient.…”

Section: Discussionmentioning

confidence: 83%

“…LFTs increased more than 10 times the upper limit of normal in most cases and frequently occurred in association with elevated total bilirubin and alkaline phosphatase. Recovery time averaged from one to three weeks after drug discontinuation [ 14 ]. Although we did not observe a concurrent rise in total bilirubin and alkaline phosphatase, our patient’s baseline characteristics fit the patients described in these case studies.…”

Section: Discussionmentioning

confidence: 99%

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Levofloxacin-Induced Hepatotoxicity in Patients With Legionnaires’ Disease: Implications and Management

Ismail,

Parikh,

Zhai

et al. 2023

Cureus

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Legionnaires' disease (LD), caused by the Legionella bacterium, primarily manifests as pneumonia and could result in a spectrum of clinical severity. As treatment necessitates the use of antibiotics, levofloxacin, a fluoroquinolone, is a commonly preferred option due to its broad-spectrum activity. However, the potential side effects of levofloxacin, including rare instances of hepatotoxicity, introduce a therapeutic challenge. This case report explores the association between levofloxacin and hepatotoxicity and its implications for treating LD.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Levofloxacin-Induced Hepatotoxicity in Patients With Legionnaires’ Disease: Implications and Management

Ismail,

Parikh,

Zhai

et al. 2023

Cureus

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“…This antibiotic has broad-spectrum activity. 23 It is widely used in urology due to its efficacy and low price. 24 In the current study, significant difference was not found in resistance ratios of levofloxacin due to relocation.…”

Section: Discussionmentioning

confidence: 99%

Investigation of some changes and clonal relationship in enterococci isolates due to relocation of a hospital

Korkoca,

Hazirolan,

Cicek

et al. 2023

J Pak Med Assoc

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Objective: To investigate the isolation rates, antimicrobial resistance rates, minimum inhibitory concentration values of antimicrobial agents, and clonal relationships of Enterococcus faecalis and Enterococcus faecium due to the relocation of a hospital to a newly constructed building. Method: The comparative, prospective study was conducted at adult general intensive care units of the Mus State Hospital, Mus, Turkey, in two phases; before the relocation from January 25 to December 1, 2014, and after the relocation from February 10 to May 24, 2015. Rectal swab samples were collected 72 hours post-hospitalisation. Identification of Enterococcus faecalis and Enterococcus faecium isolates was determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and antimicrobial resistance with minimum inhibitory concentration values was detected with Vitek 2 system. The clonal relatedness among the strains was investigated by pulsed-field gel electrophoresis. Data was analysed using SPSS 23. Results: Of the 69 patients, 37(53.62%) related to pre-relocation phase; 20(54.1%) females and 17(45.9%) males with mean age 62.81±21.71 years. There were 32(46.37%) patients in the post-relocation phase; 13(40.6%) females and 19(59.4%) males with mean age 62.69±21.35 years (p>0.05). Of the 84 enterococci strains isolated, 51(60.7%) were Enterococcus faecium; 28(55%) before relocation and 23(45%) after relocation (p=0.77). The remaining 33(39.3%) isolates were Enterococcus faecalis; 16(48.5%) before relocation and 17(51.5%) after relocation (p=0.73). Multiple strains were located in 7(18.9%) patients before relocation and in 7(21.9%) after relocation. In 1(3.1%) patient after relocation, 2(8.7%) Enterococcus faecium isolates with different resistance and pulsed-field gel electrophoresis patterns were detected. There were no significant differences between the isolation and antibiotic resistance rates before and after relocation (p>0.05), and a clonal relation between the isolates was not detected (p>0.05). Decreased minimum inhibitory concentration values were noted for some antibiotics (p<0.05). Conclusion: Clonal relationship between the isolates and change in the rates of isolation and antimicrobial resistance of Enterococcus faecalis and Enterococcus faecium was detected due to relocation. Minimum inhibitory concentration values could be used to reveal relocation-related changes in isolates obtained from patients hospitalised in intensive care units. Key Words: Enterococcus, Antimicrobial drug resistance, Transmission, Hospital moving.

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“…Some common events may include kidney injury, central nervous system disturbances, Q-T interval prolongation, and gastrointestinal tract offense. Rare occurrences include acute tendon rupture, psychosis, cardiotoxicity, and photosensitivity [ 1 ]. Transaminitis may occur as well, with fulminant hepatitis occurring exceptionally rarely.…”

Section: Introductionmentioning

confidence: 99%

Acute Immunoallergic Hepatitis in the Presence of Crohn’s Disease: A Case Presentation and Review of the Literature

Taylor¹,

Opoku²,

Obokhare³

2022

Cureus

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In this case presentation, we discuss a patient with acute immunoallergic hepatitis after fluoroquinolone use. The patient presented with a complex perianal abscess two months after the initial procedure for a perianal abscess. He was placed on broad-spectrum antibiotics and underwent fecal diversion with partial colectomy to aid in wound care and diagnosis of Crohn's disease. Acute hepatic insufficiency and ascites in the presence of a maculopapular rash suggested an immunoallergic reaction. The patient's condition improved after discontinuation of the offending drug and utilizing intravenous steroids. The diagnosis of acute immunoallergic hepatitis was made based on clinical suspicion and a careful review of the patient's medical records.

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Hepatotoxicity Secondary to Levofloxacin Use

Cited by 4 publications

References 15 publications

Levofloxacin-Induced Hepatotoxicity in Patients With Legionnaires’ Disease: Implications and Management

Levofloxacin-Induced Hepatotoxicity in Patients With Legionnaires’ Disease: Implications and Management

Investigation of some changes and clonal relationship in enterococci isolates due to relocation of a hospital

Acute Immunoallergic Hepatitis in the Presence of Crohn’s Disease: A Case Presentation and Review of the Literature

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