Hepatotoxicity of Inhaled Trichloroethylene, Tetrachloroethylene and Chloroform. Single Exposure

Kylin, B; Reichard, H; megi, I S; Yllner, Sven; Robson, Gordon

doi:10.1097/00132586-196412000-00031

Cited by 2 publications

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“…Only the experiments carried out on white mice will be discussed in this paper, while the remaining ones will be mentioned briefly. (19,20), white mice were exposed for 4 hrs to tri-and tetrachlorethylene in a fume chamber of about 15 1. volume. As control, chloroform was used.…”

Section: Animal Experiments and Resultsmentioning

confidence: 99%

Fibrinoid Necrosis of Liver Parenchymal Cells.

Sümegi

1975

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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By means of different histological and histochemical investigations and fluorescence microscopy it has been possible to demonstrate fibrinoid necrosis of parenchymal liver cells in cases of delayed chloroform death and in septic, toxic and infectious hepatitis. This type of necrosis has previously been observed only in connective tissue and in vessel walls, in particular in collagenoses. It was also possible to provoke this type of liver cell necrosis in animal experiments. Reference has been made to differences in the chemical composition of the fibrinoid substance and to relations to other related substances (amyloid, keratin, fibrin). The importance of fluorescence microscopic investigations with fluorochromes, using Novelli's method, and with certain other procedures is emphasized.

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Section: Animal Experiments and Resultsmentioning

confidence: 99%

Fibrinoid Necrosis of Liver Parenchymal Cells.

Sümegi

1975

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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“…In addition TCE has been reported to affect the liver in exposed humans and animals (Kylin et a/. 1962(Kylin et a/. , 1963(Kylin et a/.…”

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confidence: 99%

Effects of Continuous Trichloroethylene Inhalation on Different Strains of Mice

Kjellstrand

Holmquist

Mandahl

et al. 1983

Acta Pharmacologica et Toxicologica

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Seven different strains of mice (wild, C57BL, DBA, B6CBA, A/sn, NZB and NMRI) were continuously exposed to 150 ppm trichloroethylene (TCE) during 30 days. After exposure all strains showed large increases in liver weight, while changes in kidney and spleen weights were small. Plasma butyrylcholinesterase (BuChE) activity increased in males of all strains and in females of strains A/sn and NZB. The increase in the females was less than that of the corresponding males. We concluded that there are moderate, but in some cases, significant differences in TCE sensitivity between different mouse strains. The differences observed between sexes emphasizes the importance of specifying sex as well as strain when reporting on toxic effects.

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Hepatotoxicity of Inhaled Trichloroethylene, Tetrachloroethylene and Chloroform. Single Exposure

Cited by 2 publications

References 0 publications

Fibrinoid Necrosis of Liver Parenchymal Cells.

Fibrinoid Necrosis of Liver Parenchymal Cells.

Effects of Continuous Trichloroethylene Inhalation on Different Strains of Mice

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