Hepatotoxicity of herbal remedies.

MacGregor, Fiona B.; Abernethy, V. E.; Dahabra, S.; Cobden, I; Hayes, P.C.

doi:10.1136/bmj.299.6708.1156

Cited by 257 publications

(70 citation statements)

References 5 publications

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“…Hence, toxicity of mistletoe remains uncertain, while Scutellaria-associated liver damage was already assumed in a case report involving a Chinese herbal remedy 24 . Mistletoe and scullcap once again came under suspect in a combination with valerian (Valeriana of®cinalis) administered for stress relief; this preparation comprises chemical constituents with powerful alkylating agruts and therefore potentially harmful properties 86 . Recently, Mullins and Horowitz described three young men who had injected themselves with an intravenous dose of extract of lettuce and valerian hoping to experience the alleged opioid side effects of these plants.…”

Section: Miscellaneous Plantsmentioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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Objective: Hepatic impairment resulting from the use of conventional drugs is widely acknowledged, but there is less awareness of the potential hepatotoxicity of herbal preparations and other botanicals, many of which are believed to be harmless and are commonly used for self-medication without supervision. The aim of this paper is to examine the evidence for hepatotoxicity of botanicals and draw conclusions regarding their pathology, safety and applications. Design: Current literature on the hepatotoxicity of herbal drugs and other botanicals is reviewed. The aetiology, clinical picture and treatment of mushroom (Amanita) poisoning are described.

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Section: Miscellaneous Plantsmentioning

confidence: 99%

Hepatotoxicity of botanicals

Stickel

Egerer

Seitz

2000

Public Health Nutr.

133

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“…Some hepatotoxic events associated with valerian ingestion have been reported. The first cases of valerian-induced hepatotoxicity were reported in 1989, where 4 patients took over the counter sleep aids containing valerian (168). Another case of valerian hepatotoxicity was described in a 27-year-old female took 1 capsule of valerian root extract for 3 months and developed hepatic inflammation.…”

Section: Valerian (Valeriana Officinalis)mentioning

confidence: 99%

“…Accordingly, a 43-year-old woman who ingested valerian with skullcap and black cohosh and some other herbal preparations developed hepatitis (14). MacGregor et al (168) described four cases of herb-herb interaction causing hepatic injury. Four women aged between 41 and 57 developed acute hepatitis after consumption of two herbal medications (Kalms and Neurelax) for stress relief.…”

Section: Valerian (Valeriana Officinalis)mentioning

confidence: 99%

“…The second species is S. lateriflora that also known as blue skullcap, hoodwort or Virginian skullcap that is native to Americans (173,174). Scutellaria has been used as a sedative and anti-inflammatory agents (106) and for treating several ailments like cancer, jaundice, hepatitis, anxiety, nervous tension, hysteria and epilepsy (168,175,176). Both species includes terpenoid compounds, which can cause hepatotoxic effects (111).…”

Section: Skullcap (Scutellaria Baicalensis)mentioning

confidence: 99%

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Hepatotoxic Botanicals - An Evidence-based Systematic Review

Abdualmjid

Sergi

2013

J Pharm Pharm Sci

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-Purpose. Herbal medicines have been increasingly used worldwide. However, the potential harms of these herbs have been noticed most recently following hepatotoxicity with ingestion of herbal remedies. The aim of this review is to evaluate the evidence of hepatotoxic effects linked to use of herbal preparations. Method. Electronic search was performed by searching several databases: PubMed, HerbMed, Google Scholar, Scopus, Cochrane Database of Systematic Reviews and Cochrane Library using both Latin and common names of several herbs. Language was restricted to English and articles were selected for relevance reporting incidence of hepatotoxicity associated with use of herbal products in human. Results. From a total of 565 relevant reviews and articles, 254 met our inclusion criteria and were analyzed.

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“…Ethanol metabolism results in protein conjugation, free radical generation and lipid peroxidation (MacGregor et al, 1989). Ethanol plays an important role in methionine metabolism leading to progressive liver injury .…”

Section: Alcohol-induced Hepatotoxicitymentioning

confidence: 99%

Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance

et al. 2014

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The liver is a vital organ present in vertebrates, which performs many functions including detoxification, protein synthesis and production of various bio-chemicals which are very important for digestion. A large number of serious liver disorders affect millions of people worldwide which are very difficult to treat properly despite many efforts. There are several factors which are responsible for liver injuries, include plants (Crotalaria Senecio Heliotropium Symphytum officinale), drugs (analgesic and antibiotics), industrial toxins (mercury and lead), water, alcohol and so on. Herbal medicinal preparations can be used for the treatment of a large number of human liver disorders like cirrhosis, hepatitis, carcinomas, etc. Indian Medicinal Practitioner's Co-operative pharmacy and Stores (IMPCPS) approved herbal-based systems (Unani, Siddha and Ayurveda) for the treatment of various chronic liver disorders. Different types of the receptors are found on the surface of hepatocytes, Kupffer cell, hepatic stellate cell and sinusoidal endothelial cells, etc., which can be used for achieving liver targeting. These receptors bind to different types of ligands (galactosylated, lactobionic acid, asialofetuin, etc.) which can be used in the formulation to achieve targeted delivery of the drug. Various novel particulate approaches (liposomes, niosomes, nanoparticles, micelles, nanosuspensions, etc.) can be used to enhance the targeting efficiency of systems to receptors found on the surface of different cells present in the liver. In this review, we focused on the status of liver targeting via herbal and nanotechnology inspired formulation approaches.

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Hepatotoxicity of herbal remedies.

Cited by 257 publications

References 5 publications

Hepatotoxicity of botanicals

Hepatotoxicity of botanicals

Hepatotoxic Botanicals - An Evidence-based Systematic Review

Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance

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