Hepatotoxicity of Eupatorium adenophorum to rats

Katoch, Rajan; Sharma, O. P.; Dawra, Rajinder; Kurade, N. P.

doi:10.1016/s0041-0101(99)00151-8

Cited by 28 publications

(26 citation statements)

References 9 publications

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“…E. adenophorum leaves and flowers collected from Numinbah Valley (Australia) fed to rats for 52 days did not elicit any toxicity symptoms [4]. Contrariwise, E. adenophorum leaf samples collected from Kangra Valley (India) and partially purified extracts from leaf samples mixed in the diet caused hepatotoxicity and cholestasis in rats [9,10]. We report here the isolation and chemical characterization of the hepatotoxicant and describe its hepatotoxicity in rats.…”

Section: Introductionmentioning

confidence: 88%

“…Figure 1 shows the flow sheet of bioactivity-guided purification of the E. adenophorum hepatotoxicant. Extracts and fractions at different steps were subjected to TLC and bioassay in rats [9]. A comparison of the results on bioassay and TLC revealed that the extracts and fractions positive for hepatotoxicity gave pink spot on detection with vanillin-sulfuric acid spray reagent.…”

Section: Leaf Samplesmentioning

confidence: 99%

“…Male Wistar rats (180 ± 10 g) were used for the bioassays during bioactivity-guided purification of the hepatotoxicant [9,10]. The animals were kept in metabolic cages and were fasted overnight with water provided ad libitum.…”

Section: Bioassaysmentioning

confidence: 99%

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Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9‐oxo‐10,11‐dehydroageraphorone, isolated from Eupatorium adenophorum

Bhardwaj

Singh

Sharma

et al. 2001

J Biochem & Molecular Tox

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Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9-oxo-10,11-dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular necrosis, proliferation, and dilation of bile ducts with degenerative changes in the lining epithelium. There was marked increase in the conjugated form of plasma bilirubin and in the activities of the enzymes glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyltranspeptidase, glutamate dehydrogenase, and 5'-nucleotidase. The histopathological lesions in liver and biochemical profile of marker enzymes show that ODA induced hepatotoxicity and cholestasis in rats. This is the first report on the toxicity of a cadinene sesquiterpene in rats.

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Section: Introductionmentioning

confidence: 88%

Section: Leaf Samplesmentioning

confidence: 99%

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Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9‐oxo‐10,11‐dehydroageraphorone, isolated from Eupatorium adenophorum

Bhardwaj

Singh

Sharma

et al. 2001

J Biochem & Molecular Tox

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“…The use of Crofton weed as forage had been fully investigated [2]. It was toxic to grazing animals such as horses [7], mice and rats [8] with the toxin identified as 9-oxo-10, 11-dehydroageropherone [9]. A potential pathway was proposed to use Crofton weed as feedstock for production of fermentable sugars [10], which is an intermediate product for further production of bio-fuel such as ethanol.…”

Section: Introductionmentioning

confidence: 99%

Deoxy-liquefaction products obtained from Crofton weed at different temperatures

Wang

et al. 2011

Journal of Analytical and Applied Pyrolysis

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“…In some fragile ecosystems, EAS is able to change the biological diversity, alter the ecological processes and services and even compete with other native species. Additionally, EAS is a toxic species causing serious damages to plants and animals (Sharma et al 1998;Katoch et al 2000), e.g., the foliage consumption by horses can lead to pulmonary toxicity (O'Sullivan 1979); exposure of rats to feed with the freeze-dried leaf powder of EAS may cause hepatotoxicity (Ye 2001).…”

Section: Introductionmentioning

confidence: 99%

Remote Sensing of Eupatorium Adenophorum Spreng Based on HJ-A Satellite Data

Chen

Quan

Lü

2011

J Indian Soc Remote Sens

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In the southwest of China, one of the greatest threats to local ecosystem is the area expansion of an invasive species, i.e., Eupatorium adenophorum Spreng (EAS). In this study, the remote-sensing technology was used to detect and map the spatial distribution of EAS in Guizhou Province, China. A series of vegetation indices, including normalized difference vegetation index (NDVI), simple ratio index (SRI) and atmospherically resistant vegetation index (ARVI), were used to identify EAS from HJ-A Chninese satellite data. According to the analysis results of fieldworks from March 21 to 22, 2009, it was found that the vegetation index of {1.9589≤SRI≤4.1095}∩{0.2359≤ARVI≤ 0.5193} was the optimal remote-sensing parameter for identifying EAS from HJ-A data. According to the spatial distribution of EAS estimated from HJ-A data, it was found that EAS was rather more in southwest of Guizhou Province than in northeast. EAS became sparse from southwest to northeast gradually, and the central Guizhou Province was the ecological corridor linking EAS in southwest to that in northeast. By comparison with validated data collected by the government of Guizhou Province, it was found that the uncertainty of remote-sensing method was 18.52%, 29.31%, 8.77% and 9.46% in grassland, forest, farmland and others respectively, and the mean uncertainty was 13.29%. Owing to the lower height of EAS than many plants in forest, the uncertainty of EAS was the greatest in forest than that in grassland, farmland and so on.

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Hepatotoxicity of Eupatorium adenophorum to rats

Cited by 28 publications

References 9 publications

Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9‐oxo‐10,11‐dehydroageraphorone, isolated from Eupatorium adenophorum

Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9‐oxo‐10,11‐dehydroageraphorone, isolated from Eupatorium adenophorum

Deoxy-liquefaction products obtained from Crofton weed at different temperatures

Remote Sensing of Eupatorium Adenophorum Spreng Based on HJ-A Satellite Data

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