Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG

Chowdhury, Riju R.; Rose, Sophie; Ezan, Frédéric; Sovadinová, Iva; Babica, Pavel; Langouët, Sophie

doi:10.1016/j.envpol.2023.123047

Environmental Pollution

2024

DOI: 10.1016/j.envpol.2023.123047

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Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG

Riju R. Chowdhury,

Sophie Rose,

Frédéric Ezan

et al.

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Cited by 2 publications

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A review of microcystin and nodularin toxins derived from freshwater cyanobacterial harmful algal blooms and their impact on human health

Melaram,

Newton,

Lee

et al. 2024

Toxicol. Environ. Health Sci.

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The impacts of climate change on cyanobacterial harmful algal blooms (cHABs) are paramount, promoting the widespread distribution, intensity, and toxicity of these phenomena in major freshwater bodies across the globe. Microcystins (MCs) and nodularins (NODs) are monocyclic peptides that produce hepatotoxic effects in living organisms. Despite efforts in understanding their molecular toxicological mechanisms, we do not fully have a grasp on the human health impacts associated with these toxins derived from freshwater cHABs. We seek to provide a current update on the toxicity and epidemiology of MCs and NODs, integrating key evidence from in vitro, in vivo, and epidemiological studies. The primary objective of this work is to understand the human health impacts of MC and NOD-producing cHABs.

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A review of microcystin and nodularin toxins derived from freshwater cyanobacterial harmful algal blooms and their impact on human health

Melaram,

Newton,

Lee

et al. 2024

Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

show abstract

Potential (co-)contamination of dairy milk with AFM1 and MC-LR and their synergistic interaction in inducing mitochondrial dysfunction in HepG2 cells

Abdallah,

Recote,

Van Camp

et al. 2024

Food and Chemical Toxicology

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Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG

Cited by 2 publications

References 75 publications

A review of microcystin and nodularin toxins derived from freshwater cyanobacterial harmful algal blooms and their impact on human health

A review of microcystin and nodularin toxins derived from freshwater cyanobacterial harmful algal blooms and their impact on human health

Potential (co-)contamination of dairy milk with AFM1 and MC-LR and their synergistic interaction in inducing mitochondrial dysfunction in HepG2 cells

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