Hepatotoxicity of Chemotherapy

Abstract

After assessment of tumor histology, the next important factor to consider in the selection of a chemotherapy regime is organ function. Patients who are to receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate, and which drug doses should be modified. Following therapy abnormalities of liver function tests may be due to the therapy rather than to progressive disease, and this distinction is of critical importance. Furthermore, not all abnormalities in liver function are due to the tumor or its treatment, and other processes, such as hepatitis, must be kept in mind. This article reviews the hepatic toxicity of chemotherapeutic agents, and suggests dose modifications based upon liver function abnormalities. Emphasis is placed on agents known to be hepatotoxic, and those agents with hepatic metabolism.

Can lactoferrin modulate the immunostimulant activity of levamisole in rats immunosuppressed by cyclophosphamide?

“…Also, we found that the CYP-immunosuppressed rats showed significant decrease in γ-globulins levels, these findings are parallel to the results observed by [13]. This may be due to the toxic effects of various chemotherapeutic on the liver, including cyclophosphamide, which was found to inhibit selected hepatic enzymes as described by [33]. CYP exerts a specific and not directly toxic effect on the cytochrome P450 system, which converts cyclophosphamide to active metabolites.…”

Protective Effect of Astragalus polysaccharides on Liver Injury Induced by Several Different Chemotherapeutics in Mice

“…Histological changes including liver congestion, disorganization of hepatic cords and ballooning degeneration could be observed in H&E slides. At the same time we have found a remarkable decrease in body weight gain after mice being treated with CTX, notably in high dose group, implying that hepatotoxicity might have contributed to this weight loss as previously reported (King and Perry, 2001;Basu et al, 2014). In addition, we also discovered that the expression level of apoptosis-related protein caspase-3 increased in the liver of mice after received CTX.…”

Antioxidant Mediated Defense Role of Ecliptaalba Herbal Extract Against Ccl4 Inducedtoxic Hepatitis

“…Serum total bilirubin was estimated following the method of King and Coxon [17]. In brief, 1 ml of serum was mixed with 0.5 ml of diazo reagent, followed by 0.5 ml (NH4)2SO4.…”