Hepatotoxicity of Antibiotics and Antifungals and Their Safe Use in Hepatic Impairment
J. Ma,
E. S. Björnsson,
N. Chalasani
Abstract:Idiosyncratic drug-induced liver injury (DILI) is a rare and unpredictable form of hepatotoxicity. While its clinical course is usually benign, cases leading to liver transplantation or death can occur. Based on modern prospective registries, antimicrobials including antibiotics and antifungals are frequently implicated as common causes. Amoxicillin–clavulanate ranks as the most common cause for DILI in the Western World. Although the absolute risk of hepatotoxicity of these agents is low, as their usage is qu… Show more
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