Hepatotoxicity induced by fosinopril

A prospective study of acute drug‐induced liver injury in patients suffering from non‐alcoholic fatty liver disease

“…Furthermore, it has been difficult to compare our data with a control population because the available data from the literature are fragmentary and have not always been submitted to precise and complete statistical analyses. Nevertheless, reports obtained from referenced medical journals and/or the database of the World Health Organization show that for the considered drugs, the prevalence of DILI in patients without liver disease is much lower than that observed in our population of patients suffering from NAFLD 10–16 . Finally, it has not been possible to clearly exclude a toxic role of alcohol in determining major susceptibility to DILI, although the relative risk was not modified by light alcohol consumption.…”

Effect of angiotensin II and bradykinin inhibition in rat reduced-size liver transplantation

“…ACE inhibitors are widely used in clinical practice 39, 40. However, hepatotoxicity and cholestatic liver diseases have been reported under ACE inhibition 41, 42. Taking these observations into account, along with the fact that AT1R antagonists and AT2R antagonists were as effective as ACE inhibitors in terms of hepatic injury, we propose that the most suitable strategy to be applied in ROLT to reduce hepatic injury and increase liver regeneration is the combination of Ang II receptor antagonists together with BK receptor antagonists.…”