Hepatotoxicity evaluation of dextran stabilized iron oxide nanoparticles in Wistar rats

Surface modification affect the biodistribution and toxicity characteristics of iron oxide magnetic nanoparticles in rats

“…Interestingly, vascular congestion, necrosis, and inflammatory infiltrate in the liver and kidney were also found on the 14th day after intravenous administration in previous study [1γ]. The results in this work were consistent with the conclusion that IOMNs coated with function materials can still induce side effects [11][12][13][14].…”

“…Silva et al [13] reported that IOMNs coated with PEG2000 with different dosage (12.5, 25, and 50 mg/kg) caused vascular congestion, necrosis, and inflammatory infiltrate in the liver and kidneys on the 14th day after intravenous administration. Easo and Mohanan [14] found that dextran stabilised iron oxide nanoparticles (NPs) could induce oxidative stress response in liver at days 1 and 7 after intravenous exposure (10 mg/kg). Therefore, it was essential to evaluate and compare the possible side effects of IOMNs with different surface modification, especially after long‐term recovery in vivo .…”

Effects of Iron Oxide Nanoparticles on Structural Organization of Hepatocyte Chromatin: Gray Level Co-occurrence Matrix Analysis

“…In 2016, Kazemipour and associates tested the potential hepatotoxicity of large doses (100 mg/kg) of IONPs in rats and observed significant oxidative damage in the liver tissue (Kazemipour et al, 2018). Lower doses such as the one of 10 mg/kg seem not to cause significant changes of lipid peroxidation levels or modulation of hepatic enzymes as recently shown by Easo & Mohanan (2016). Also, a relatively recent study of Parivar and associates (2016) showed that large doses (300 μ g/gr) of IONP induce morphological changes in the liver tissue such as spotty necrosis, while lower doses seem to have no significant adverse effects (Parivar et al, 2016).…”

Genotoxicity, biochemical, and biodistribution studies of magnesium oxide nano and microparticles in albino wistar rats after 28‐day repeated oral exposure

“…Increased levels of these enzymes in the tissue homogenates may be due to the extent of hepatocellular injury leading to possible leakage of these enzymes into the bloodstream . A study by Easo et al reported functional integrity of cell membrane would be lost resulting in perturbation of transport function of hepatocytes causes tissue necrosis. Similar alterations of ALP, AST, and ALT were observed with other metal NPs .…”