Hepatotoxicity caused by methylparaben in adult zebrafish

Hu, Chen-Yan; Sun, Baili; Tang, Lizhu; Liu, Mengyuan; Huang, Zileng; Zhou, Xin; Chen, Lianguo

doi:10.1016/j.aquatox.2022.106255

Cited by 16 publications

(5 citation statements)

References 37 publications

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“…So it would seem that its adverse effect on humans and animals is insignificant. However, more recent investigations have found that chronic or subchronic exposure to MeP may affect various internal organs and systems (including liver, cardiovascular and neuronal systems) and shows carcinogenic properties [77][78][79] . Moreover, some toxic activities of MeP are visible even at low environmentally concentrations of this substance 77,79 .…”

Section: Discussionmentioning

confidence: 99%

“…However, more recent investigations have found that chronic or subchronic exposure to MeP may affect various internal organs and systems (including liver, cardiovascular and neuronal systems) and shows carcinogenic properties [77][78][79] . Moreover, some toxic activities of MeP are visible even at low environmentally concentrations of this substance 77,79 . These facts, together with the widespread occurrence of MeP in the environment, suggest that this substance may be harmful to living organisms.…”

Section: Discussionmentioning

confidence: 99%

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Exposure assessment of dairy cows to parabens using hair samples analysis

Gonkowski,

Tzatzarakis,

Kadyralieva

et al. 2024

Sci Rep

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Parabens (PBs) are used as preservatives in various products. They pollute the environment and penetrate living organisms, showing endocrine disrupting activity. Till now studies on long-term exposure of farm animals to PBs have not been performed. Among matrices using in PBs biomonitoring hair samples are becoming more and more important. During this study concentration levels of methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP) butyl paraben (BuP) and benzyl paraben (BeP) were evaluated using liquid chromatography–mass spectrometry (LC–MS) in hair samples collected from dairy cows bred in the Kyrgyz Republic. MeP was noted in 93.8% of samples (with mean concentration levels 62.2 ± 61.8 pg/mg), PrP in 16.7% of samples (12.4 ± 6.5 pg/mg) and EtP in 8.3% of samples (21.4 ± 11.9 pg/mg). BuP was found only in one sample (2.1%) and BeP was not detected in any sample included in the study. Some differences in MeP concentration levels in the hair samples depending on district, where cows were bred were noted. This study has shown that among PBs, dairy cows are exposed mainly to MeP, and hair samples may be a suitable matrix for research on PBs levels in farm animals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure assessment of dairy cows to parabens using hair samples analysis

Gonkowski,

Tzatzarakis,

Kadyralieva

et al. 2024

Sci Rep

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“…These findings suggest that parabens disrupt lipid metabolism. 5 Another study conducted on zebrafish demonstrated that parabens induce oxidative stress, apoptosis, and alterations in fatty acid metabolism, leading to damage. 22 Although the exact mechanisms through which parabens affect lipid metabolism are not fully understood, it is evident that they disrupt the metabolic process.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

İnkaya¹

2023

J Clin Pract Res

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Objective: This research aimed to study the effects of co-exposure to methylparaben and propylparaben (MeP+PrP) on renal and hepatic parameters in male rats. Materials and Methods: MeP and PrP were mixed at a ratio of 1:1. MeP+PrP doses were administered to 42-day-old male rats on a daily basis for 30 days. Each of the five groups consisted of six male rats, including three MeP+PrP dose groups with daily combination doses of 10 mg/kg bw, 100 mg/kg bw, and 500 mg/kg bw. The other two groups included the positive control group exposed to a daily dose of 50 mg/kg bw Bisphenol-A (BPA), and the corn oil control group used as a vehicle. At the end of the procedure period, liver and kidney tissues were obtained from histopathological analysis, morphometric analysis was performed on kidney tissue, and hematological and biochemical parameters were examined. Results: Histopathological changes, such as tubular degeneration, edema, fibrous tissue formation, and congestion, were observed in the kidney tissue, while degeneration, edema, and congestion were observed in the liver tissue. Statistical analysis comparing the administered groups to the corn oil control group revealed significant variations in biochemistry and hematological markers. Conclusion: These findings demonstrate that co-exposure to MeP and PrP alters biochemical and hematological parameters and negatively affects the liver and kidney tissues of male rats.

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“…The liver is a major site of vertebrate material metabolism, and the zebrafish liver contains enzymes capable of metabolizing multiple endogenous and exogenous compounds similar to the human liver. Because some drugs or chemicals can cause liver damage in zebrafish, including the occurrence of vacuolization in the liver (Duan et al, 2022; Hu et al, 2022; Huang, Liu, et al, 2022; Wang, Huang, Liu, et al, 2022), liver size changes and liver steatosis (Lu, Yang, Zhu, et al, 2022), apoptosis and necrotic (Chen, Wang, et al, 2022; Siqueira et al, 2022), liver inflammation, dysregulation of lipid metabolism and glycolysis in the liver (Li et al, 2022), and hepatic lipid peroxidation (Song et al, 2022). See Table 4 for the details.…”

Section: Hepatotoxicity In Zebrafishmentioning

confidence: 99%

Frontier of toxicology studies in zebrafish model

Shao,

Xiao,

Yang

et al. 2023

J of Applied Toxicology

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Based on the 87 original publications only from quartiles 1 and 2 of Journal Citation Report (JCR) collected by the major academic databases (Science Direct, Web of Science, PubMed, and Wiley) in 2022, the frontier of toxicology studies in zebrafish model is summarized. Herewith, a total of six aspects is covered such as developmental, neurological, cardiovascular, hepatic, reproductive, and immunizing toxicities. The tested samples involve chemicals, drugs, new environmental pollutants, nanomaterials, and its derivatives, along with those related mechanisms. This report may provide a frontier focus benefit to researchers engaging in a zebrafish model for environment, medicine, food, and other fields.

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Hepatotoxicity caused by methylparaben in adult zebrafish

Cited by 16 publications

References 37 publications

Exposure assessment of dairy cows to parabens using hair samples analysis

Exposure assessment of dairy cows to parabens using hair samples analysis

Investigation of the Combined Effects of Propylparaben and Methylparaben on Biochemical and Histological Parameters in Male Rats

Frontier of toxicology studies in zebrafish model

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