Hepatotoxicity Associated with Pharmacologic Agents in Dogs and Cats

Bunch, Susan E.

doi:10.1016/s0195-5616(93)50311-x

Cited by 38 publications

(34 citation statements)

References 16 publications

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“…4-6 Cholestasis can develop subsequent to obstructive hepatic or posthepatic disease, hepatic infections, compressive periportal lesions, or hepatocyte swelling, which leads to impaired canalicular bile flow 4,6-8 Hyperphosphatasemia commonly results from high circulating concentrations of endogenous or exogenous corticosteroids; other drugs, particularly anticonvulsants, can also induce de novo synthesis of ALP. 6,[9][10][11][12][13] The From the…”

Section: Conclusion and Clinical Relevance-hyperphosphatasemia In Apmentioning

confidence: 99%

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Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers

Zimmerman¹,

Panciera²,

Panciera³

et al. 2010

javma

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Section: Conclusion and Clinical Relevance-hyperphosphatasemia In Apmentioning

confidence: 99%

“…3,4,6,13,14 Other causes of hyperphosphatasemia in adult dogs include increased osteoblastic activity associated with increased bone modeling (or remodeling) and lytic lesions of bone. 4,6,[14][15][16][17][18] Scottish Terriers reportedly have higher ALP activities than do other breeds.…”

mentioning

confidence: 99%

Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers

Zimmerman¹,

Panciera²,

Panciera³

et al. 2010

javma

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“…Thiamine is essential for neuronal glucose metabolism and often deficient in times of increased metabolic demand [12]. Thiamine deficiency has been reported to cause symptoms of seizures, behavioural change, and ataxia in cats [13] so supplementation was considered appropriate in this case.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal Necrosis in a Cat from Australia

Adagra

Piripi

2014

Case Reports in Veterinary Medicine

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This paper reports findings from a feline case of hippocampal necrosis. A seven-year-old neutered female cat was seen with a history of behavioural change followed by complex focal seizures. The cat was severely pyrexic on presentation and anisocoria was present. It was treated with cooling, intravenous fluid, and phenobarbitone administration which was later changed to levetiracetam. An MRI was performed and revealed findings of a hypointense T1 and hyperintense T2 signal in the hippocampus and inferior temporal gyrus with mild gadolinium uptake, findings which were consistent with previous cases of hippocampal necrosis. The cat was witnessed to vomit and aspirate 24 hours after diagnosis leading to cardiac arrest and death. Postmortem examination revealed a subacute degenerative encephalopathy involving the hippocampus.

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“…Doberman Pinschers have also been suggested to be predisposed to diethylcarbamazine/oxibendazole hepatotoxicity. 18 It is possible that hepatopathy induced by amiodarone is an idiosyncratic reaction in Doberman Pinschers. However, the occurrence of hepatopathy in the 3 Doberman Pinschers may be related to the frequency of amiodarone use in the breed in our hospital, because 8 of 10 dogs that have received amiodarone were Doberman Pinschers.…”

Section: Discussionmentioning

confidence: 99%

Hepatopathy in 4 Dogs Treated with Amiodarone

Jacobs

Calvert

Kraus

2000

Veterinary Internal Medicne

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Amiodarone is a class III antiarrhythmic drug used in dogs with dilated cardiomyopathy and ventricular tachyarrhythmias. Hepatopathy is one of the more commonly reported adverse effects of amiodarone use in people. We describe 4 dogs that developed hepatopathy associated with amiodarone administration; 2 dogs also developed neutropenia. Three dogs had clinical signs of anorexia and lethargy; 1 did not show signs until impaired liver function had developed. Clinical signs or biochemical abnormalities developed 1.5-8 months after amiodarone treatment was started. Clinical signs resolved within 2 weeks of discontinuing amiodarone, but biochemical abnormalities did not resolve for 6-8 weeks. The delay between onset of liver disease and overt clinical signs suggests that serial evaluation of liver enzyme activities following amiodarone use in dogs is important.

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Hepatotoxicity Associated with Pharmacologic Agents in Dogs and Cats

Cited by 38 publications

References 16 publications

Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers

Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish Terriers

Hippocampal Necrosis in a Cat from Australia

Hepatopathy in 4 Dogs Treated with Amiodarone

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