Hepatotoxicity and renal toxicity induced by gamma-radiation and the modulatory protective effect of Ficus carica in male albino rats

Fouad, Dalia; Alhatem, Hassah; Abdel‐Gaber, Rewaida; Ataya, Farid S.

doi:10.1016/j.rvsc.2019.05.010

Cited by 25 publications

(13 citation statements)

References 37 publications

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“…However, the reduction in albumin and total protein concentrations in the present work was consistent with the results of Fouad et al 41 This drop in protein level post irradiated might be the cause of destruction of vital biological processes or due to impairments in the permeability kidney causing leakage of protein mainly albumin through the kidney 42…”

Section: Discussionsupporting

confidence: 93%

“…These data agree with that reported by Aziz et al 39 who reported that, the increase in creatinine level may be due to the back-leakage of the filtered creatinine through the injuried tubular epithelium. In addition, Sayed et al 40 suggested that these increments in serum urea and creatinine could be attributed to the destruction and malfunction of kidney cells due to the action of ROS released post radiation exposure.However, the reduction in albumin and total protein concentrations in the present work was consistent with the results of Fouad et al41 This drop in protein level post irradiated might be the cause of destruction of vital biological processes or due to impairments in the permeability kidney causing leakage of protein mainly albumin through the kidney 42.…”

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confidence: 93%

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Protective effects of Saraca indica L. leaves extract (family Fabaceae) against gamma irradiation induced injury in the kidney of female albino rats

Mohamed

Mohammed

Mostafa

et al. 2020

Environmental Toxicology

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This work was designed to estimate the protective effect of Saraca indica L. leaves ethanolic exract against γ‐irradiation induced renal damage in rats. Phytochemical examinations of S. indica L. leaves extract resulted in the separation of three flavanone glycosides: Astilibin (1), Neoastilbin (2), and Eriodictyol‐7‐O‐α‐l‐rhamnopyranoside (3); two flavonols: Quercetin (4) and Quercetin‐3‐O‐α‐l‐arabinopyranosyl‐(1′′′‐6′′)‐O‐β‐D‐galactopyranoside (5) in addition of Gallic acid (6) and methyl gallate (7). Their structures elucidated by chemical evidences and spectroscopic analysis (1 and 2D‐NMR, ‐ESI‐MS, UV). Female rats were used and classified into: control, Ext (200 mg/kg body wt/day orally for 7 days), IRR (8Gy), Ext + IRR, and Sily+IRR groups (received silymarin 50 mg/kg b.wt orally as reference drug). Results showed that S. indica L. leaves extract ameliorated the kidney function tests, hs‐CRP, IL‐1β, ACE, TNF‐α, GSH, and MDA as well as, decreased the histopathological changes of kidney. In conclusion, S. indica L. leaves extract had a renoprotective activity against irradiation induced renal injury due to its flavononid contents.

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Section: Discussionsupporting

confidence: 93%

supporting

confidence: 93%

Protective effects of Saraca indica L. leaves extract (family Fabaceae) against gamma irradiation induced injury in the kidney of female albino rats

Mohamed

Mohammed

Mostafa

et al. 2020

Environmental Toxicology

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“…Asthma Digestive system [1] Pathologies of the digestive system, pathologies of the circulatory system, and cardiovascular diseases [4] Anticancer [102] Hepatoprotective and nephroprotective [103] Myrtaceae Diabetes [6] Asthma [57] Antibacterial activity [104] Hypoglycemic activity [105] 10 Evidence-Based Complementary and Alternative Medicine Diabetes [6] Cardiac weakness, digestive system [1] Antioxidant activity [106] Antigenotoxic effect [107] Hypoglycemic effect [108] Myrtaceae [19] Antiviral [111] Antibacterial and antifungal [112] Pedaliaceae Sesamum indicum L.…”

Section: Rab82-16mentioning

confidence: 99%

Traditional Knowledge of Medicinal Plants Used in the Northeastern Part of Morocco

Kachmar

Mrabti

Bellahmar

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The knowledge of the plants that are used may provide insight on their properties for further exploration. This study aimed to identify and collect data about medicinal plants used in traditional medicine by the population of the provincial region of Taza, Morocco. An ethnobotanical survey was carried out among 200 informants, competent villagers, herbalists, and traditional healers from the provincial region of Taza city through direct interviews using a structured questionnaire. The survey reported 55 plant species belonging to 28 families used in the folk medicine. Informants’ results showed that the most frequently used plants were Origanum compactum, Mentha pulegium, Rosmarinus officinalis L., Aloysia citrodora, Calamintha officinalis Moench, and Artemisia herba-alba Asso., with a relative frequency of citation of 76%, 72%, 60%, 42%, 40%, and 30%, respectively. Moreover, in this study, the Lamiaceae family was the most commonly reported plant family, and the leaves were the most frequently used parts of the plants; otherwise, decoction and infusion were the most used modes in the preparation of remedies from medicinal plants in the traditional medicine. The sociodemographic characteristics showed that women use medicinal plants slightly more than men, the illiterate people use the medicinal plant the most, and old people have more information about the medicinal plants than the new generations. The region of Taza of Morocco has an important floristic biodiversity of medicinal plants which are used in traditional medicine practice. This result provides a good database for pharmacological screening in the search for new plants that can contain new bioactive molecules that can be used as a bioactive ingredient of medicament or as a biological alternative in pharmacology.

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“…During radiotherapy, IR can induce hepatotoxicity developing liver injury in normal hepatic cells, thereby limiting the radiotherapy treatment course or developing critical‐chronic side effects, such as late fibrosis 12,13 . Exposure to IR accounts for production of reactive oxygen species (ROS), disturbance in the antioxidant status, protein‐denature, as well as, damaging of macromolecules the likes of membrane lipids and DNA 14,15 . Acetaminophen and gamma‐irradiation combined treatment, that induces hepato‐renal toxicity has been studied previously 16 .…”

Section: Introductionmentioning

confidence: 99%

Biochemical study on the protective effect of curcumin on acetaminophen and gamma‐irradiation induced hepatic toxicity in rats

Eassawy

Salem

Ismail

2020

Environmental Toxicology

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Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID‐19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the current study represents that treatment of rats with either APAP‐overdose, or gamma‐irradiation (R) induces hepatotoxicity, results in significant increases of the hepatic‐enzymes activities (ALT, AST, ALP, GGT, LDH, and MDH), as well as enhancement of triglycerides, total cholesterol levels, combined with declines in albumin and total protein contents. An enhancement of the lipid peroxides (malondialdehyde; MDA), and nitric oxide levels along with a decline of reduced glutathione contents and suppression of superoxide dismutase, catalase, and glutathione peroxidase activities are also observed within the liver tissues of intoxicated animals. TNF‐α, IL‐1β, IL‐6, iNOS, Cytochrome P450 2E1 (CYP2E1), miR‐802 gene expression, NF‐κB, and calcium levels are up‐regulated, while Nuclear factor erythroid‐related factor‐2 (Nrf2), Hemoxygenase‐1 (HO‐1) protein and gene expressions, as well as, glutamate‐cysteine ligase catalytic subunit (GCLC), NAD(P)H‐Quinone oxidoreductase (NQO1), and miR‐122 gene expressions are down‐regulated in the livers of intoxicated animals. All these parameters show significant improvement in R/APAP intoxicated animals. Curcumin pretreatment develops an amelioration of these effects in APAP‐overdose, R‐exposure, or R/APAP treatments. In conclusion, oral administration of curcumin shows hepatoprotective effects against APAP‐overdose induced hepatic damage in normal and gamma‐irradiated rats through prospective regulation of the therapeutic targets CYP2E1, Nrf2, and NF‐κB, via organizing the miR‐122 and miR‐802 gene expression.

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Hepatotoxicity and renal toxicity induced by gamma-radiation and the modulatory protective effect of Ficus carica in male albino rats

Cited by 25 publications

References 37 publications

Protective effects of Saraca indica L. leaves extract (family Fabaceae) against gamma irradiation induced injury in the kidney of female albino rats

Protective effects of Saraca indica L. leaves extract (family Fabaceae) against gamma irradiation induced injury in the kidney of female albino rats

Traditional Knowledge of Medicinal Plants Used in the Northeastern Part of Morocco

Biochemical study on the protective effect of curcumin on acetaminophen and gamma‐irradiation induced hepatic toxicity in rats

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