Hepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administration

Song, Erqun; Xia, Xiaomin; Su, Chuanyang; Dong, Wenjing; Xian, Yaping; Wang, Jiaqiang; Song, Yang

doi:10.1016/j.fct.2014.06.009

Cited by 55 publications

(46 citation statements)

References 50 publications

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“…Although the concentration of patulin would be expected to be lower in a cup of properly prepared tea than the roughly 1000 μg/kg found by us in dry tea leaves, the patulin concentrations in prepared tea would be expected to surpass the limit set by the FDA. The discrepancy between our finding of high patulin concentration and the healthy reputation enjoyed by Pu-erh may be explained by the modulation of patulin toxicity through the action of green tea polyphenols [ 77 ].…”

Section: Discussionmentioning

confidence: 64%

The Microbiome and Metabolites in Fermented Pu-erh Tea as Revealed by High-Throughput Sequencing and Quantitative Multiplex Metabolite Analysis

et al. 2016

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Pu-erh is a tea produced in Yunnan, China by microbial fermentation of fresh Camellia sinensis leaves by two processes, the traditional raw fermentation and the faster, ripened fermentation. We characterized fungal and bacterial communities in leaves and both Pu-erhs by high-throughput, rDNA-amplicon sequencing and we characterized the profile of bioactive extrolite mycotoxins in Pu-erh teas by quantitative liquid chromatography-tandem mass spectrometry. We identified 390 fungal and 629 bacterial OTUs from leaves and both Pu-erhs. Major findings are: 1) fungal diversity drops and bacterial diversity rises due to raw or ripened fermentation, 2) fungal and bacterial community composition changes significantly between fresh leaves and both raw and ripened Pu-erh, 3) aging causes significant changes in the microbial community of raw, but not ripened, Pu-erh, and, 4) ripened and well-aged raw Pu-erh have similar microbial communities that are distinct from those of young, raw Ph-erh tea. Twenty-five toxic metabolites, mainly of fungal origin, were detected, with patulin and asperglaucide dominating and at levels supporting the Chinese custom of discarding the first preparation of Pu-erh and using the wet tea to then brew a pot for consumption.

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Section: Discussionmentioning

confidence: 64%

The Microbiome and Metabolites in Fermented Pu-erh Tea as Revealed by High-Throughput Sequencing and Quantitative Multiplex Metabolite Analysis

et al. 2016

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“…Frequently, patulin has been found in many fruits such as cherries, blueberries, plums, kiwifruit, pears, bananas, apricots, peaches, strawberries, and grapes etc [23,24]. Although the harm of patulin to human health has remained inconclusive, a number of animals and cells studies have suggested that patulin could cause teratogenic effects [25], carcinogenic effects [26], reproductive toxicity [27] and genotoxicity [28]. In general, the amount of patulin in apple products is viewed as a measure of quality standard.…”

Section: Introductionmentioning

confidence: 99%

Adsorptive removal of patulin from aqueous solution using thiourea modified chitosan resin

Liu

Peng

Chen

et al. 2015

International Journal of Biological Macromolecules

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“…These findings correlate with previous studies that emphasize the importance of several antioxidants to cope with PAT‐induced toxicity. Indeed, Ayed‐Boussemma et al (2013) revealed that vitamin E inhibits PAT‐induced apoptosis in HEPG2 cells, and Song et al () demonstrated that green tea polyphenols reduce PAT‐induced oxidative stress in liver tissues and attenuate genotoxicity in bone morrow and they also revealed that selenium inhibits PAT‐induced genotoxicity in brain tissues.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism underlying its toxicity was investigated both in vivo and in vitro. For instance, PAT induces DNA strand breaks (Liu et al, ; Zhou et al, ), chromosome aberrations (Ayed‐Boussema et al, ), and micronuclei formation (Alves et al, ; Song et al, ). In addition, it was evidenced that this mycotoxin exerts cytotoxicity through reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress activation leading to apoptosis (Boussabbeh et al, ).…”

Section: Introductionmentioning

confidence: 99%

Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway

et al. 2015

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Patulin (PAT) is a secondary metabolite produced by several species of the genera of Penicillium, Aspergillus, and Byssochlamys that can be found in rotting fruits, especially in apples and apple-based products. Exposure to this mycotoxin has been reported to induce intestinal and kidney injuries. The mechanism underlying such toxicity has been linked to the induction of apoptosis which occurred with reactive oxygen species production and endoplasmic reticulum (ER) stress induction. This study aimed to evaluate the effect of the two common dietary compounds Quercetin (QUER), a natural flavonoid, and Crocin (CRO), a natural carotenoid, on PAT-induced toxicity in human colon carcinoma (HCT116) and embryonic kidney cells (HEK293). We showed that antioxidant properties of QUER and CRO help to prevent ER stress activation and lipid peroxidation as evidenced by the reduction in GRP78 and GADD34 expressions and the decrease in malondialdehyde production. Furthermore, we demonstrated their ability to re-establish the loss of the mitochondrial membrane potential to inhibit caspase 3 activation and DNA fragmentation. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1851-1858, 2016.

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Hepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administration

Cited by 55 publications

References 50 publications

The Microbiome and Metabolites in Fermented Pu-erh Tea as Revealed by High-Throughput Sequencing and Quantitative Multiplex Metabolite Analysis

The Microbiome and Metabolites in Fermented Pu-erh Tea as Revealed by High-Throughput Sequencing and Quantitative Multiplex Metabolite Analysis

Adsorptive removal of patulin from aqueous solution using thiourea modified chitosan resin

Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway

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