Hépatotoxicité tardive à l’imatinib chez une patiente de 44 ans

Imatinib mesylate-induced acute hepatotoxicity

“…The onset of hepatic dysfunction from the use of Imatinib ranged from 12 days to 2 years with a median time of 100 days. 1,7,8 In our case, hepatic cytolysis was discovered in the fifth month from the start of the drug. This delay remains compatible with drug impairment.…”

“…However, cases of death have been reported by Thia et al 9 There are sometimes links to the association with another underlying cause such as AgHbs carriage 9 or taking paracetamol. 1 Resolution of hepatic injury may be spontaneous after discontinuation of treatment. Some authors suggest shortterm corticosteroid therapy, especially in the event of the onset of grade 3 and 4 liver toxicity.…”

“…Liver dysfunction is known to reverse with the discontinuation of imatinib, 1 within a period varying from 1 to 10 weeks. 8 In the case reported by Diallo et al, 1 the normalization of the balance sheet was obtained within six months following imatinib discontinuation. In our case, the liver test normalized after 12 weeks.…”

“…Prescription of imatinib requires biological monitoring due to potential adverse effects, in particular hepatotoxicity, which remains a complication, although rare, but sometimes serious. 1 We report, a clinical case of acute toxic imatinib generic (cemivil®) induced hepatitis in a 51-year-old man with CML. This adverse effect was notified to the Regional Center for Pharmacovigilance in Sfax (Tunisia) on 09/30/ 2017 under the registration number: 340/17 and analyzed according to the French imputability method.…”

“…Prescription of imatinib requires biological monitoring due to potential adverse effects, in particular hepatotoxicity, which remains a complication, although rare, but sometimes serious. 1…”