Hepatotoxic and Nephrotoxic Effects of Kerosene and Petrol-Contaminated Diets in Wistar Albino Rats

Sonographic assessment of petroleum-induced hepatotoxicity in Nigerians: does biochemical assessment underestimate liver damage?

“…Chronic exposure to these products must have led to the increase in hepaticaminotransferases as the mean values in the exposed differed significantly compared to the control. This finding is in accord with the findings of other researchers 3,6,8 The increase in the serum levels of these parameters is a sign of liver injury or dysfunction 25 . This is because when there is liver damage, enzymes and other metabolites escape from the cellular compartment into the extracellular fluid resulting in the increase in the concentrations 25 .…”

“…Petroleum products are known hepatotoxicants, causing increase in hepatic aminotransferases 3 . This type of petroleum product induced-hepatotoxicity detectable by biochemical assessment is well described, but the sonographic findings in the liver in chronic exposure are not well studied particularly in the black African population.…”

“…This also exposes the occupants of these apartments to petrol fumes. Apart from these, petroleum products have been abused as therapeutic agents for the treatment of snake bites, convulsion, arthritis, gastro-intestinal disorders and a host of other conditions 3 . Individuals who are occupationally exposed like those who work in petroleum industries or with petroleum distillates are likely to be more affected than their counterparts who do not work in these industries 4 .…”

Dysfunctional Liver and other High Metabolic Organs in Asymptomatic Petroleum Depot Workers in Calabar South-South, Nigeria

“…The alkaline phosphatase (ALP) activity was higher (p<0.05) in the depot workers which may imply alterations in the synthesis and transport of the enzyme following obstructive liver disease (Halim et al, 1997). This result agrees with that of Nwanjo and Ojiako (2007) in petrol station workers and that of Patrick-Iwuanyanwu et al (2011) but in rats fed on kerosene and petrol contaminated diets. The higher (p<0.05) aspartate amino transferase (AST) activity observed in the exposed group as against the control agrees with the report of Nwanjo and Ojiako (2007) for petrol station workers.…”

“…The result is in consonance with that of Nwanjo and Ojiako (2007) in petrol station workers and with that of Patrick-Iwuanyanwu et al (2011) in rats fed on kerosene and petrol contaminated diets. Gamma Glutamyl Transpeptidase (GGT) activity in the exposed group was higher by 99.12% relative to the control group, suggesting liver associated damage in the exposed group (Hyder et al, 2013).…”