Hepatotoksisitas Pada Pengobatan Tuberkulosis Di Rsud Tangerang – Indonesia

Ningrum, Vitarani Dwi Ananda; Megasari, Arnia; Hanifah, Suci

doi:10.20885/jif.vol7.iss1.art2

Cited by 4 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, increasing the risk of serious side effects. [7][8][9] If there is acute hepatitis (caused by a virus) that is not related to TB disease, treatment should be postponed until the acute condition improves. In patients with severe and unstable hepatic impairment, liver function tests should be performed before treatment starts.…”

Section: Case Presentationmentioning

confidence: 99%

“…There is no consensus as to which drug to administer for different degrees of liver damage, although WHO guidelines state that the more unstable or severe the liver disease, the fewer hepatotoxic drugs 3157 should be used. 9,10 In patients with a history of pre-existing functional impairment, it is important to diagnose the cause and degree of existing liver dysfunction before starting anti-TB drugs. In chronic liver disease, it is necessary to determine the severity of the disease according to Child-Pugh criteria.…”

Section: Case Presentationmentioning

confidence: 99%

See 1 more Smart Citation

Management of Pulmonary Tuberculosis in Liver Cirrhosis: A Case Report

Gorga¹,

Medison²,

F.³

2023

Bioscmed

View full text Add to dashboard Cite

Background: Anti-tuberculosis drugs (OAT) are metabolized in the liver and have a high potential for hepatotoxicity, and will increase the risk of drug-induced liver injury (DILI). This study aimed to describe the management of pulmonary tuberculosis in patients with cirrhosis of the liver. Case presentation: 45 years old male patient with cough with phlegm for 5 months, weight loss. The patient is also known to have cirrhosis of the liver. From the results of the bacteriological examination, it was found that TCM mtb was detected as high. The patient has risk factors for low BMI, a history of alcohol, hypo albumin, and comorbid hepatic cirrhosis. This patient was given a hepatoprotection. After liver function improved, the patient was started on anti-tuberculosis drugs with a regimen of 2 hepatotoxic drugs, namely isoniazid, rifampin, and ethambutol, given gradually and planned to be given for 9 months, with regular monitoring of liver function in the first 2 months. Conclusion: Effective management of pulmonary tuberculosis infection depends on giving OAT at the appropriate dose and duration. The selection of regimen and duration of therapy can be considered based on the condition of chronic liver disease. Careful assessment and periodic evaluation of liver function are required.

show abstract

Section: Case Presentationmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

Management of Pulmonary Tuberculosis in Liver Cirrhosis: A Case Report

Gorga¹,

Medison²,

F.³

2023

Bioscmed

View full text Add to dashboard Cite

show abstract

“…(1) Efek OAT dapat memicu kerusakan sel-sel hati secara kronis dan atau kerusakan kolestatis hati akibat gangguan aliran empedu (2) . Pemeriksaan tes fungsi hati yaitu fungsi ekskresi diperiksa dengan pemeriksaan bilirubin total (3). Apabila terdapat gangguan, maka kadar bilirubin serum total meningkat dan menyebabkan ikterik (4).…”

Section: Pendahuluanunclassified

Penurunan Kadar Bilirubin Total Serum Yang Diencerkan Pada Penderita Tuberkulosis

Putri

Widada

Setiawan

2021

JALM

View full text Add to dashboard Cite

Pemeriksaan tes fungsi hati dianjurkan untuk dilakukan terlebih dahulu sebelum dilakukan pengobatan TBC dan pada saat pengobatan. Peningkatan kadar bilirubin total lima kali lipat dari batas normal merupakan salah satu dari 3 kriteria pasien tuberkulosis paru menderita cedera hati akibat penggunaan obat. Salah satu penanganan serum pekat akibat penggunaan OAT (Obat Anti Tuberkulosis) adalah dengan perlakuan pengenceran. Pengencernan dilakukan dengan penambahan NaCL fisiologis perbandingan. Penelitian ini dilakukan untuk mengetahui penurunan kadar bilirubin total setelah dilakukan pengenceran pada serum penderita tuberkulosis. Penelitian ini merupakan penelitian Pre-experimental Design dengan desain penelitian One-Group Pretest-Posttest Design. Sampel penelitian sebanyak 30 sampel serum pasien tuberkulosis dengan kadar Bilirubin Total serum lebih dari 6,0 mg/dL. Data yang diperoleh dianalisis secara deskriptif dan menggunakan Uji Paired Sample T-Test. Penelitian ini memperoleh hasil bahwa terjadi penurunan kadar rerata selisih kadar Bilirubin total serum pasien tuberkulosis sebesar 0.29 mg/dL (2,70%) pada serum dengan pengenceran dengan nilai signifikansi sebesar 0,000 (<0,05) yang berarti ada perbedaan kadar Bilirubin total pada serum pasien tuberkulosis dengan dan tanpa pengenceran. Pada serum penderita TBC yang pekat sebaiknya dilakukan pengenceran untuk mengurangi kesalahan kadar tinggi palsu yang berakibat pada kesalahan penghentian pengobatan.

show abstract

“…A hepatoprotector, such as curcumin, can also be prescribed to protect the liver from damage. The administration of anti-TB drug can be stopped if the increase in ALT levels exceeds thrice the upper limit of normal (ULN), with an increase in bilirubin levels, or an increase in the ALT levels exceeds 5 times the ULN without increasing the bilirubin level [20].…”

Section: Drug Interactionmentioning

confidence: 99%

Identification of Drug-Related Problems in Adults With Tuberculosis at the Tebet Subdistrict Health Center From July to December 2018

Puspitasari¹,

Yunaz

Nadhilah³

2020

Int J App Pharm

View full text Add to dashboard Cite

Objective: Tuberculosis (TB) is a highly prevalent infectious disease caused by Mycobacterium tuberculosis. The recommended TB treatment is acombination of various antibiotics in the form of a fixed-dose combination tablet or kombipak; however, this increases the prevalence of drug-relatedproblems. Therefore, this study aimed to identify drug-related problems of patients receiving TB therapy at the Tebet Subdistrict Health Center fromJuly 2018 to December 2018.Methods: The study was designed as a cross-sectional study using the retrospective data retrieval method from prescriptions of patients withTB from July 2018 to December 2018. The classification system prepared by Cipolle, Strand, and Morley was used for the classification of drugrelatedproblems; this system includes unnecessary drug therapy, required additional drug therapy, ineffective drug, dosage error, and druginteraction.Results: The percentage of unnecessary drug therapy, required additional drug therapy, ineffective drug, dosage error, and drug interaction was2.85%, 6.89%, 1.54%, 12.46%, and 66.18%, respectively, with the occurrence of drug-related problems being the highest.Conclusion: The administration of anti-TB drugs can potentially cause drug-related problems. Therefore, the assessment needs to be optimizedbefore the administration of medications to patients and medications should be prescribed and monitored regularly to achieve rational drug use

show abstract

Hepatotoksisitas Pada Pengobatan Tuberkulosis Di Rsud Tangerang – Indonesia

Cited by 4 publications

References 0 publications

Management of Pulmonary Tuberculosis in Liver Cirrhosis: A Case Report

Management of Pulmonary Tuberculosis in Liver Cirrhosis: A Case Report

Penurunan Kadar Bilirubin Total Serum Yang Diencerkan Pada Penderita Tuberkulosis

Identification of Drug-Related Problems in Adults With Tuberculosis at the Tebet Subdistrict Health Center From July to December 2018

Contact Info

Product

Resources

About