1994
DOI: 10.1093/clinids/18.6.979
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Hepatosplenic Yeast Infection in Patients with Acute Leukemia: A Diagnostic Problem

Abstract: The occurrence of hepatosplenic candidiasis following prolonged neutropenic periods has emerged as a major problem for patients with leukemia. In order to evaluate the diagnostic value of various available procedures, we analyzed our findings regarding 26 leukemic patients with hepatosplenic candidiasis. A significantly increased level (> 50 mg/L) of serum C-reactive protein (S-CRP) was significantly more common than a daily fever (for which the mean temperature peak was > 37.5 degrees C) or raised levels of l… Show more

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Cited by 84 publications
(49 citation statements)
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“…Biliary stricture may lead to cholestasis, which in turn can allow micro-organisms from the gut to ascend into the biliary tract. In patients with hematologic malignancies, the yield of positive culture is often less than 50%, with the diagnosis usually based on microscopic examination or histopathological finding from deep tissues [1,3,4,7] . Nevertheless, fungal cultures had repeatedly been positive in our patient.…”
Section: Discussionmentioning
confidence: 99%
“…Biliary stricture may lead to cholestasis, which in turn can allow micro-organisms from the gut to ascend into the biliary tract. In patients with hematologic malignancies, the yield of positive culture is often less than 50%, with the diagnosis usually based on microscopic examination or histopathological finding from deep tissues [1,3,4,7] . Nevertheless, fungal cultures had repeatedly been positive in our patient.…”
Section: Discussionmentioning
confidence: 99%
“…This fungal pathogen causes a clinical significant problem in immunocompromised patients [1][2][3][4][5]. To the patients who were treated with antifungal drugs, disseminated candidiasis due to C. albicans can be a serious cause which often leads to death [6]. Besides the disseminated disease, this fungus causes local infections like vulvovaginal candidiasis in which C. albicans is the most common etiological agent and thrush [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…This diagnosis poses a challenge and requires a high degree of suspicion from clinicians involved in the care of patients with acute leukemia [5, 6]. Liver biopsy demonstrating the presence of pseudohyphae and yeast forms is important to establish the diagnosis of HSC.…”
Section: Introductionmentioning
confidence: 99%