Hepatosplenic T-cell lymphoma: Sinusoidal localization of malignant T-cells—a case report

Kakkar, Nandita; Banerjee, Arundhati; Marwaha, Neelam; Deodhar, S. D.

doi:10.1002/(sici)1096-8652(199612)53:4<278::aid-ajh16>3.0.co;2-8

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Gaulard and his group were the first to distinguish a peculiar subset of γδ TCR‐positive peripheral T‐cell neoplasms with an unusual clinicopathological presentation 4 –7 . Following their initial description, several reports on similar cases have been published 8 –42 . Because of their striking uniformity with respect to clinical, morphological, immunophenotypical and genotypical features, this group of lymphomas was listed as a provisional entity in the Revised European–American Lymphoma (REAL) classification and termed ‘hepatosplenic γδ T‐cell lymphoma’ 43 .…”

Section: Introductionmentioning

confidence: 99%

γδ T‐cell lymphomas: a homogeneous entity?

Wolf‐Peeters

Achten

2000

Histopathology

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gammadelta T-cells comprise an immunologically distinct lymphoid population, characterized by specific morphological, phenotypical and functional properties. Therefore it seems reasonable to speculate that neoplasms derived from this particular T-cell subset display distinct features. Indeed, the prototype gammadelta T-cell lymphoma, hepatosplenic T-cell lymphoma constitutes a unique clinicopathological entitity which is intimately associated with a gammadelta T-cell phenotype. However, gammadelta T-cell lymphomas have also been described in other extranodal sites where, unlike reactive gammadelta T-cells and hepatosplenic gammadelta T-cell lymphomas, they display an important morphological heterogeneity. Moreover, these nonhepatosplenic gammadelta T-cell lymphomas are essentially not that different from their alphabeta T-cell receptor for antigen (TCR)-expressing counterparts and thus may be incorporated in the established T-cell lymphoma subclasses. However, subtle differences regarding their histopathological appearance as well as their biological behaviour indicate that further studies to determine the exact significance of TCR expression are required. Such inquiries may contribute to the general understanding of T-cell lymphomagenesis in general, which is still obscure.

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Section: Introductionmentioning

confidence: 99%

γδ T‐cell lymphomas: a homogeneous entity?

Wolf‐Peeters

Achten

2000

Histopathology

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2021

Flow Cytometry of Hematological Malignancies

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Hepatosplenic T-cell lymphoma and inflammatory bowel disease

Thai

Prindiville

2010

Journal of Crohn's and Colitis

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Hepatosplenic T-cell lymphoma is a rare disease, often with a poor outcome. With the increasing number of reported cases of HSTCL linked to the use of infliximab, adalimumab, and AZA/6-MP, there appears to be an undeniable association of HSTCL development with the use of these agents. This risk is unquantifiable. When considering the rarity of cases and the multiple complications with uncontrolled disease, however, the benefit of treatment far outweighs the risk.

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Hepatosplenic T-cell lymphoma: Sinusoidal localization of malignant T-cells—a case report

Cited by 3 publications

References 4 publications

γδ T‐cell lymphomas: a homogeneous entity?

γδ T‐cell lymphomas: a homogeneous entity?

References

Hepatosplenic T-cell lymphoma and inflammatory bowel disease

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