Hepatosplenic sarcoidosis

Abstract

Sarcoidosis is a systemic disorder characterized by development of granulomas within various organs in the body. It commonly affects people of African American and Scandinavian heritage between the ages of 20 and 40. The lungs are involved in 90% of patients. We report a case of sarcoidosis of the spleen and liver with minimal pulmonary involvement.

Unusual presentation of multiorgan extrapulmonary sarcoidosis

“…Ana Lilia Peralta Amaro 1,2 Tania Stefanía Cabrera Castillo 1,2 María de los Ángeles Macias Clavijo 2,3 Fernando Méndez Gallegos…”

“…Diagnosis often relies on characteristic chest radiography findings, but approximately 10% of patients show noncaseating granulomas on biopsy without pulmonary abnormalities. 2 Herein, we present a unique case of multiorgan sarcoidosis, where the sole manifestations were severe thrombocytopenia, weight loss, and a history of cerebral vascular events.…”

“…Commonly, it targets the eyes, skin, lymph nodes, and, in rare instances, the liver and spleen. 2 The development of the disease is significantly influenced by genetic and environmental factors, as well as gene variations on chromosome 6. Notably, first-degree relatives of patients have a heightened risk factor of 3.7.…”