Hepatorenal syndrome: A disease mediated by the intrarenal action of renin

Ziegler, Thomas W.

doi:10.1016/s0306-9877(76)80017-5

Cited by 3 publications

(2 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood pressure is decreased in these situations and it has been suggested that this is a consequence of decreased formation of angiotensin subsequent to the decrease in the concentration of angiotensinogen in plasma (52). Indeed, it has been hypothesized that the low angiotensinogen levels in cirrhotic patients are ultimately responsible for the development of the hepatorenal syndrome (14,233). Few data are available to support or deny these speculations, and further investigation is required.…”

Section: Influ Ence Of Angiotensinogen Concentration On the Renin-angmentioning

confidence: 99%

The Renin-Angiotensin System

Reid¹,

Morris²,

Ganong³

1978

Annu. Rev. Physiol.

523

176

View full text Add to dashboard Cite

Since the discovery of renin 80 years ago, there have been remarkable advances in our understanding of the renin-angiotensin system. The system as it is known today is summarized in Figure 1. Angiotensin III, the active component of the system, has several important physiological actions. The fi rst of these to be identifi ed was its pressor action, and for many years it was felt that the sole function of the renin-angiotensin system was regula tion of blood pressure. A new dimension was added in 1960 with the discovery that angiotensin II stimulates the secretion of aldosterone and is therefore in a position to exert important effects on salt and water balance. Several additional actions of angiotensin II were then discovered. It was fo und that the peptide can increase the secretion of catecholamines from the adrenal and facilitate adrenergic transmission. It also acts directly on the brain to increase blood pressure via sympathetic and parasympathetic path ways, to produce thirst, and to stimulate the secretion of vasopressin and ACTH. Through these actions, the renin-angiotensin system plays an im portant role in the regulation of blood pressure and of the volume and composition of the extracellular fl uid.Major advances have also been made in our understanding of other aspects of the renin-angiotensin system. It has become clear that the hep tapeptide metabolite of angiotensin II, [des-Aspl] angiotensin II ("angioIThe IUPAC-IUB Commission on Biochemical Nomenclature Recommenda tions (J. Dial Chem.2S0:321S) has suggested that the peptide hormones referred to in this review-angiotensin I, angiotensin II, ACTH, and growth hormone-be termed proangiotensin, angiotensin, corticotropin, and somatotropin, respectively.

show abstract

Section: Influ Ence Of Angiotensinogen Concentration On the Renin-angmentioning

confidence: 99%

The Renin-Angiotensin System

Reid¹,

Morris²,

Ganong³

1978

Annu. Rev. Physiol.

523

176

View full text Add to dashboard Cite

show abstract

“…In advanced liver disease with fluid retention and renal failure, the renin-angiotensin system is characterized by: 1) a considerable increase in plasma renin activity due to accelerated production while reduced hepatic inactivation seems of minor importance (175-177) (Fig. 2, IX); 2) an elevated angiotensin I1 level (177)(178)(179)(180)(181); and 3), as a result of 2), a reduced systemic pressure and renal circulatory response to infusion of angiotensin I1 (182)(183)(184).…”

Section: Hyperactivity Of the Renin-angiotensin Systemmentioning

confidence: 99%